Platinum and palladium complexes with 2,4-Dinitrophenylhydrazine: synthesis and cytotoxic activity

New complexes of platinum and palladium were isolated with 2,4-dinitrophenylhydrazine (2,4-DNPH). These complexes were characterized and the results shown that the ligand is coordinated to platinum or palladium by the basic nitrogen of NH2 group and have the general structure cis-[M(2,4- DNPH)2Cl2 ]...

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Detalles Bibliográficos
Autores principales:	Souza, Gustavo D. de, Fernandes, Lucianno E., Rodrigues, Mônica A., Silva, Priscila P., Pereira-Maia, Elene C., Guerra, Wendell
Formato:	Articulo Comunicacion
Lenguaje:	Inglés
Publicado:	2012
Materias:	Farmacia Cytotoxic activity Hydrazones Metal-based drugs Platinum complexes Paladio Hidrazonas
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/20207 http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_2_2.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Cytotoxic activity Hydrazones Metal-based drugs Platinum complexes Paladio Hidrazonas
spellingShingle	Farmacia Cytotoxic activity Hydrazones Metal-based drugs Platinum complexes Paladio Hidrazonas Souza, Gustavo D. de Fernandes, Lucianno E. Rodrigues, Mônica A. Silva, Priscila P. Pereira-Maia, Elene C. Guerra, Wendell Platinum and palladium complexes with 2,4-Dinitrophenylhydrazine: synthesis and cytotoxic activity
topic_facet	Farmacia Cytotoxic activity Hydrazones Metal-based drugs Platinum complexes Paladio Hidrazonas
description	New complexes of platinum and palladium were isolated with 2,4-dinitrophenylhydrazine (2,4-DNPH). These complexes were characterized and the results shown that the ligand is coordinated to platinum or palladium by the basic nitrogen of NH2 group and have the general structure cis-[M(2,4- DNPH)2Cl2 ].H2O where M = Pt or Pd. The thermal stability of the complexes was followed in the temperature range 25-850 ºC. The antitumor activity of the synthesized compounds has been studied and the compound cis-[Pt(2,4-DNPH)2Cl2 ], was found to display cytotoxicity (IC50 = 4.6 μmol/L) against K562 tumoral cell line. This work is the first to describe the cytotoxic activity of complexes containing 2,4-dinitrophenylhydrazine
format	Articulo Comunicacion
author	Souza, Gustavo D. de Fernandes, Lucianno E. Rodrigues, Mônica A. Silva, Priscila P. Pereira-Maia, Elene C. Guerra, Wendell
author_facet	Souza, Gustavo D. de Fernandes, Lucianno E. Rodrigues, Mônica A. Silva, Priscila P. Pereira-Maia, Elene C. Guerra, Wendell
author_sort	Souza, Gustavo D. de
title	Platinum and palladium complexes with 2,4-Dinitrophenylhydrazine: synthesis and cytotoxic activity
title_short	Platinum and palladium complexes with 2,4-Dinitrophenylhydrazine: synthesis and cytotoxic activity
title_full	Platinum and palladium complexes with 2,4-Dinitrophenylhydrazine: synthesis and cytotoxic activity
title_fullStr	Platinum and palladium complexes with 2,4-Dinitrophenylhydrazine: synthesis and cytotoxic activity
title_full_unstemmed	Platinum and palladium complexes with 2,4-Dinitrophenylhydrazine: synthesis and cytotoxic activity
title_sort	platinum and palladium complexes with 2,4-dinitrophenylhydrazine: synthesis and cytotoxic activity
publishDate	2012
url	http://sedici.unlp.edu.ar/handle/10915/20207 http://www.latamjpharm.org/resumenes/31/4/LAJOP_31_4_2_2.pdf
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Platinum and palladium complexes with 2,4-Dinitrophenylhydrazine: synthesis and cytotoxic activity

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