Encapsulation of olanzapine into beeswax microspheres: preparation, characterization and release kinetics

The objective of the present study was to minimise the unwanted side effects of olanzapine (OZ) drug by kinetic control of drug release by entrapping into gastro resistant, biodegradable waxes such as beeswax (BW) microspheres using meltable emulsified dispersion cooling induced solidification techn...

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Detalles Bibliográficos
Autores principales:	Manjunath, M., Aravindram, A. S., Vishwanathan, B., Ahmed, Faruqui M., Gowda, D. Vishakant, Khan, Mohammed S.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2012
Materias:	Farmacia Cinética Ceras Sistemas de Liberación de Medicamentos
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/25639 http://www.latamjpharm.org/resumenes/31/6/LAJOP_31_6_1_3.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-25639
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Cinética Ceras Sistemas de Liberación de Medicamentos
spellingShingle	Farmacia Cinética Ceras Sistemas de Liberación de Medicamentos Manjunath, M. Aravindram, A. S. Vishwanathan, B. Ahmed, Faruqui M. Gowda, D. Vishakant Khan, Mohammed S. Encapsulation of olanzapine into beeswax microspheres: preparation, characterization and release kinetics
topic_facet	Farmacia Cinética Ceras Sistemas de Liberación de Medicamentos
description	The objective of the present study was to minimise the unwanted side effects of olanzapine (OZ) drug by kinetic control of drug release by entrapping into gastro resistant, biodegradable waxes such as beeswax (BW) microspheres using meltable emulsified dispersion cooling induced solidification technique utilizing a wetting agent. Solid, discrete, reproducible free flowing microspheres were obtained. The yield of the microspheres was up to 94.0 %. The microspheres had smooth surfaces, with free flowing and good packing properties, indicating that the obtained angle of repose, % Carr’s index and tapped density values were well within the limit. More than 97.0 % of the isolated spherical microspheres were in the particle size range of 312-330 μm were confirmed by scanning electron microscopy (SEM) photographs. The drug loaded in microspheres was stable and compatible, as confirmed by DSC and FTIR studies. The release of drug was controlled for more than 8 h. Intestinal drug release from microspheres was studied and compared with the release behaviour of commercially available formulation Olanex®. The release kinetics followed different transport mechanisms. The drug release from the bees wax microspheres was found sufficient for oral delivery and the drug release profile was significantly affected by the properties of wax used in the preparation of microspheres. These results demonstrate the potential use of wax for the fabrication of controlled delivery devices for many water soluble drugs.
format	Articulo Articulo
author	Manjunath, M. Aravindram, A. S. Vishwanathan, B. Ahmed, Faruqui M. Gowda, D. Vishakant Khan, Mohammed S.
author_facet	Manjunath, M. Aravindram, A. S. Vishwanathan, B. Ahmed, Faruqui M. Gowda, D. Vishakant Khan, Mohammed S.
author_sort	Manjunath, M.
title	Encapsulation of olanzapine into beeswax microspheres: preparation, characterization and release kinetics
title_short	Encapsulation of olanzapine into beeswax microspheres: preparation, characterization and release kinetics
title_full	Encapsulation of olanzapine into beeswax microspheres: preparation, characterization and release kinetics
title_fullStr	Encapsulation of olanzapine into beeswax microspheres: preparation, characterization and release kinetics
title_full_unstemmed	Encapsulation of olanzapine into beeswax microspheres: preparation, characterization and release kinetics
title_sort	encapsulation of olanzapine into beeswax microspheres: preparation, characterization and release kinetics
publishDate	2012
url	http://sedici.unlp.edu.ar/handle/10915/25639 http://www.latamjpharm.org/resumenes/31/6/LAJOP_31_6_1_3.pdf
work_keys_str_mv	AT manjunathm encapsulationofolanzapineintobeeswaxmicrospherespreparationcharacterizationandreleasekinetics AT aravindramas encapsulationofolanzapineintobeeswaxmicrospherespreparationcharacterizationandreleasekinetics AT vishwanathanb encapsulationofolanzapineintobeeswaxmicrospherespreparationcharacterizationandreleasekinetics AT ahmedfaruquim encapsulationofolanzapineintobeeswaxmicrospherespreparationcharacterizationandreleasekinetics AT gowdadvishakant encapsulationofolanzapineintobeeswaxmicrospherespreparationcharacterizationandreleasekinetics AT khanmohammeds encapsulationofolanzapineintobeeswaxmicrospherespreparationcharacterizationandreleasekinetics
bdutipo_str	Repositorios
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Encapsulation of olanzapine into beeswax microspheres: preparation, characterization and release kinetics

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