Neural processing of emotional facial and semantic expressions in euthymic bipolar disorder (BD) and its association with theory of mind (ToM)

Background: Adults with bipolar disorder (BD) have cognitive impairments that affect face processing and social cognition. However, it remains unknown whether these deficits in euthymic BD have impaired brain markers of emotional processing. Methodology/Principal Findings: We recruited twenty six pa...

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Detalles Bibliográficos
Autores principales: Ibáñez, Agustín, Urquina, Hugo, Petroni, Agustín, Baez, Sandra, López, Vladimir, Nascimento, Micaela do, Herrera, Eduard, Guex, Raphael, Hurtado, Esteban, Blenkmann, Alejandro, Beltrachini, Leandro, Gelormini, Carlos, Sigman, Mariano, Lischinsky, Alicia, Torralva, Teresa, Torrente, Fernando M., Cetkovich, MArcelo, Manes, Facundo Francisco
Formato: Articulo
Lenguaje:Español
Publicado: 2012
Materias:
Ingeniería
Medicina
Emociones
Neuropsicología
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/29741
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0046877
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SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-29741
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Español
topic Ingeniería
Medicina
Emociones
Neuropsicología
spellingShingle Ingeniería
Medicina
Emociones
Neuropsicología
Ibáñez, Agustín
Urquina, Hugo
Petroni, Agustín
Baez, Sandra
López, Vladimir
Nascimento, Micaela do
Herrera, Eduard
Guex, Raphael
Hurtado, Esteban
Blenkmann, Alejandro
Beltrachini, Leandro
Gelormini, Carlos
Sigman, Mariano
Lischinsky, Alicia
Torralva, Teresa
Torrente, Fernando M.
Cetkovich, MArcelo
Manes, Facundo Francisco
Neural processing of emotional facial and semantic expressions in euthymic bipolar disorder (BD) and its association with theory of mind (ToM)
topic_facet Ingeniería
Medicina
Emociones
Neuropsicología
description Background: Adults with bipolar disorder (BD) have cognitive impairments that affect face processing and social cognition. However, it remains unknown whether these deficits in euthymic BD have impaired brain markers of emotional processing. Methodology/Principal Findings: We recruited twenty six participants, 13 controls subjects with an equal number of euthymic BD participants. We used an event-related potential (ERP) assessment of a dual valence task (DVT), in which faces (angry and happy), words (pleasant and unpleasant), and face-word simultaneous combinations are presented to test the effects of the stimulus type (face vs word) and valence (positive vs. negative). All participants received clinical, neuropsychological and social cognition evaluations. ERP analysis revealed that both groups showed N170 modulation of stimulus type effects (face > word). BD patients exhibited reduced and enhanced N170 to facial and semantic valence, respectively. The neural source estimation of N170 was a posterior section of the fusiform gyrus (FG), including the face fusiform area (FFA). Neural generators of N170 for faces (FG and FFA) were reduced in BD. In these patients, N170 modulation was associated with social cognition (theory of mind). Conclusions/Significance: This is the first report of euthymic BD exhibiting abnormal N170 emotional discrimination associated with theory of mind impairments.
format Articulo
Articulo
author Ibáñez, Agustín
Urquina, Hugo
Petroni, Agustín
Baez, Sandra
López, Vladimir
Nascimento, Micaela do
Herrera, Eduard
Guex, Raphael
Hurtado, Esteban
Blenkmann, Alejandro
Beltrachini, Leandro
Gelormini, Carlos
Sigman, Mariano
Lischinsky, Alicia
Torralva, Teresa
Torrente, Fernando M.
Cetkovich, MArcelo
Manes, Facundo Francisco
author_facet Ibáñez, Agustín
Urquina, Hugo
Petroni, Agustín
Baez, Sandra
López, Vladimir
Nascimento, Micaela do
Herrera, Eduard
Guex, Raphael
Hurtado, Esteban
Blenkmann, Alejandro
Beltrachini, Leandro
Gelormini, Carlos
Sigman, Mariano
Lischinsky, Alicia
Torralva, Teresa
Torrente, Fernando M.
Cetkovich, MArcelo
Manes, Facundo Francisco
author_sort Ibáñez, Agustín
title Neural processing of emotional facial and semantic expressions in euthymic bipolar disorder (BD) and its association with theory of mind (ToM)
title_short Neural processing of emotional facial and semantic expressions in euthymic bipolar disorder (BD) and its association with theory of mind (ToM)
title_full Neural processing of emotional facial and semantic expressions in euthymic bipolar disorder (BD) and its association with theory of mind (ToM)
title_fullStr Neural processing of emotional facial and semantic expressions in euthymic bipolar disorder (BD) and its association with theory of mind (ToM)
title_full_unstemmed Neural processing of emotional facial and semantic expressions in euthymic bipolar disorder (BD) and its association with theory of mind (ToM)
title_sort neural processing of emotional facial and semantic expressions in euthymic bipolar disorder (bd) and its association with theory of mind (tom)
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/29741
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0046877
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