Association between GNRHR, LHR and IGF1 polymorphisms and timing of puberty in male Angus cattle

Background: In bovines, there are significant differences within and among beef breeds in the time when bulls reach puberty. Although the timing of puberty is likely to be a multigenic trait, previous studies indicate that there may also be single genes that exert major effects on the timing of pube...

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Autores principales: Lirón, Juan Pedro, Prando, Alberto José, Fernández, María Elena, Ripoli, María Verónica, Rogberg Muñoz, Andrés, Goszczynski, Daniel Estanislao, Posik, Diego Manuel, Peral García, Pilar, Baldo, Andrés, Giovambattista, Guillermo
Formato: Articulo
Lenguaje:Español
Publicado: 2012
Materias:
Ciencias Veterinarias
gonadorelin receptor
bovine
somatomedin
gonadotropin releasing hormone receptor
cattle
insulin-like growth factor 1
luteinizing hormone receptor
gene sequence
polymorphism
genetic variability
genotype
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/37519
http://www.biomedcentral.com/content/pdf/1471-2156-13-26.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-37519
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Español
topic Ciencias Veterinarias
gonadorelin receptor
bovine
somatomedin
gonadotropin releasing hormone receptor
cattle
insulin-like growth factor 1
luteinizing hormone receptor
gene sequence
polymorphism
genetic variability
genotype
spellingShingle Ciencias Veterinarias
gonadorelin receptor
bovine
somatomedin
gonadotropin releasing hormone receptor
cattle
insulin-like growth factor 1
luteinizing hormone receptor
gene sequence
polymorphism
genetic variability
genotype
Lirón, Juan Pedro
Prando, Alberto José
Fernández, María Elena
Ripoli, María Verónica
Rogberg Muñoz, Andrés
Goszczynski, Daniel Estanislao
Posik, Diego Manuel
Peral García, Pilar
Baldo, Andrés
Giovambattista, Guillermo
Association between GNRHR, LHR and IGF1 polymorphisms and timing of puberty in male Angus cattle
topic_facet Ciencias Veterinarias
gonadorelin receptor
bovine
somatomedin
gonadotropin releasing hormone receptor
cattle
insulin-like growth factor 1
luteinizing hormone receptor
gene sequence
polymorphism
genetic variability
genotype
description Background: In bovines, there are significant differences within and among beef breeds in the time when bulls reach puberty. Although the timing of puberty is likely to be a multigenic trait, previous studies indicate that there may also be single genes that exert major effects on the timing of puberty within the general population. Despite its economic importance, there are not many SNPs or genetic markers associated with the age of puberty in male cattle. In the present work, we selected three candidate genes, <i>GNRHR</i>, <i>LHR</i> and <i>IGF1</i>, and associated their polymorphisms with the age of puberty in Angus male cattle. Results: After weaning, 276 Angus males were measured every month for weight (W), scrotal circumference (SC), sperm concentration (C) and percentage of motility (M). A total of 4 SNPs, two within <i>GNRHR</i>, one in <i>LHR</i> and one in <i>IGF1</i> were genotyped using the pyrosequencing technique. <i>IGF1-SnaBI SNP</i> was significant associated (P < 0.01) with age at SC 28 cm, but it were not associated with age at M 10% and C 50 million. Genotype CC exhibited an average age at SC 28 cm of 7 and 11 days higher than CT (p = 0.037) and TT (p = 0.012), respectively. This SNP explained 1.5% of the genetic variance of age of puberty at SC28. <i>LHR-I499L, GNRHR-SNP5</i> and <i>GNRHR-SNP6</i> were not associated with any of the measurements. However, <i>GNRHR</i> haplotypes showed a suggestive association with age at SC 28 cm. Conclusions: The findings presented here could support the hypothesis that IGF1 is a regulator of the arrival to puberty in male calves and is involved in the events that precede and initiate puberty in bull calves. Given that most studies in cattle, as well as in other mammals, were done in female, the present results are the first evidence of markers associated with age at puberty in male cattle.
format Articulo
Articulo
author Lirón, Juan Pedro
Prando, Alberto José
Fernández, María Elena
Ripoli, María Verónica
Rogberg Muñoz, Andrés
Goszczynski, Daniel Estanislao
Posik, Diego Manuel
Peral García, Pilar
Baldo, Andrés
Giovambattista, Guillermo
author_facet Lirón, Juan Pedro
Prando, Alberto José
Fernández, María Elena
Ripoli, María Verónica
Rogberg Muñoz, Andrés
Goszczynski, Daniel Estanislao
Posik, Diego Manuel
Peral García, Pilar
Baldo, Andrés
Giovambattista, Guillermo
author_sort Lirón, Juan Pedro
title Association between GNRHR, LHR and IGF1 polymorphisms and timing of puberty in male Angus cattle
title_short Association between GNRHR, LHR and IGF1 polymorphisms and timing of puberty in male Angus cattle
title_full Association between GNRHR, LHR and IGF1 polymorphisms and timing of puberty in male Angus cattle
title_fullStr Association between GNRHR, LHR and IGF1 polymorphisms and timing of puberty in male Angus cattle
title_full_unstemmed Association between GNRHR, LHR and IGF1 polymorphisms and timing of puberty in male Angus cattle
title_sort association between gnrhr, lhr and igf1 polymorphisms and timing of puberty in male angus cattle
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/37519
http://www.biomedcentral.com/content/pdf/1471-2156-13-26.pdf
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