Oral Metformin Treatment Counteracts Adipoinsular Axis Dysfunction in Hypothalamic Obese Rats

Rats neonatally treated withmonosodiumL-glutamate (MSG) are deeply dysfunctional in adulthood. We explored the effect of an oral low dose of metformin treatment in male MSG rats on adipoinsular axis and visceral adipose tissue (VAT) dysfunctions, in both basal (nonfasting) and endotoxemia conditions...

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Autores principales: Castrogiovanni, Daniel Cayetano, Ongaro Gambino, Luisina, Zubiría, María Guillermina, Giovambattista, Andrés, Spinedi, Eduardo Julio
Formato: Articulo
Lenguaje:Inglés
Publicado: 2015
Materias:
Ciencias Médicas
Metformina
metformin, MSG rats, obese phenotypes
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/76664
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-76664
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Metformina
metformin, MSG rats, obese phenotypes
spellingShingle Ciencias Médicas
Metformina
metformin, MSG rats, obese phenotypes
Castrogiovanni, Daniel Cayetano
Ongaro Gambino, Luisina
Zubiría, María Guillermina
Giovambattista, Andrés
Spinedi, Eduardo Julio
Oral Metformin Treatment Counteracts Adipoinsular Axis Dysfunction in Hypothalamic Obese Rats
topic_facet Ciencias Médicas
Metformina
metformin, MSG rats, obese phenotypes
description Rats neonatally treated withmonosodiumL-glutamate (MSG) are deeply dysfunctional in adulthood. We explored the effect of an oral low dose of metformin treatment in male MSG rats on adipoinsular axis and visceral adipose tissue (VAT) dysfunctions, in both basal (nonfasting) and endotoxemia conditions. MSG rats, treated or not treated with metformin (30 days prior to experimentation), and control litter-mates (CTR) were studied at 90 days of age. Peripheral concentrations of glucose, lipids, and hormones were determined in basal and post-lipopolysaccharide (LPS) treatment conditions. Food intake and body weight (BW) were recorded and VAT mass and leptin mRNA levels were evaluated. Data indicated that MSG rats were lighter and displayed hypercorticosteronemia, hypophagia, adipoinsular axis hyperactivity, and enhanced VAT mass associated with an increased leptin gene expression. Interestingly,metformin-treatedMSG rats corrected BWcatch-up and counteracted VAT (mass and leptinmRNA level) and adipoinsular axis (basal and post-LPS) dysfunctions. Thus metformin treatment in MSG rats is able to correct several VAT and metabolic-endocrine dysfunctions. Our study suggests that a low-dose metformin therapy is effective to correct, at least in part, adipoinsular axis dysfunction in hypertrophic obese phenotypes, such as that of the human Cushing syndrome.
format Articulo
Articulo
author Castrogiovanni, Daniel Cayetano
Ongaro Gambino, Luisina
Zubiría, María Guillermina
Giovambattista, Andrés
Spinedi, Eduardo Julio
author_facet Castrogiovanni, Daniel Cayetano
Ongaro Gambino, Luisina
Zubiría, María Guillermina
Giovambattista, Andrés
Spinedi, Eduardo Julio
author_sort Castrogiovanni, Daniel Cayetano
title Oral Metformin Treatment Counteracts Adipoinsular Axis Dysfunction in Hypothalamic Obese Rats
title_short Oral Metformin Treatment Counteracts Adipoinsular Axis Dysfunction in Hypothalamic Obese Rats
title_full Oral Metformin Treatment Counteracts Adipoinsular Axis Dysfunction in Hypothalamic Obese Rats
title_fullStr Oral Metformin Treatment Counteracts Adipoinsular Axis Dysfunction in Hypothalamic Obese Rats
title_full_unstemmed Oral Metformin Treatment Counteracts Adipoinsular Axis Dysfunction in Hypothalamic Obese Rats
title_sort oral metformin treatment counteracts adipoinsular axis dysfunction in hypothalamic obese rats
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/76664
work_keys_str_mv AT castrogiovannidanielcayetano oralmetformintreatmentcounteractsadipoinsularaxisdysfunctioninhypothalamicobeserats
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bdutipo_str Repositorios
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