Improving the phototoxicity of the zinc phthalocyanine by encapsulation in nanoparticles: preparation, characterization and phototherapy studies

Nanoparticles are widely utilized to overcome drugs insolubility problems and sustain release improving the bioavailability. Zinc phthalocyanine, a hydrophobic photosensitizer with solubility problems, was loaded in PLA nanoparticles. Photosensitizer loaded in polymeric nanoparticles was produced wi...

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Autores principales: Soares, Mariana V., Lanzarini, Cíntia M., Oliveira, Daniely S., Ramos-Júnior, Paulo R.S., Santos, Elizabete P., Ricci-Júnior, Eduardo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
Oncología
cancer; nanoparticles; photodynamic therapy; photosensitizer
Farmacología
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7864
http://www.latamjpharm.org/resumenes/29/1/LAJOP_29_1_1_1.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7864
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Oncología
cancer; nanoparticles; photodynamic therapy; photosensitizer
Farmacología
spellingShingle Farmacia
Oncología
cancer; nanoparticles; photodynamic therapy; photosensitizer
Farmacología
Soares, Mariana V.
Lanzarini, Cíntia M.
Oliveira, Daniely S.
Ramos-Júnior, Paulo R.S.
Santos, Elizabete P.
Ricci-Júnior, Eduardo
Improving the phototoxicity of the zinc phthalocyanine by encapsulation in nanoparticles: preparation, characterization and phototherapy studies
topic_facet Farmacia
Oncología
cancer; nanoparticles; photodynamic therapy; photosensitizer
Farmacología
description Nanoparticles are widely utilized to overcome drugs insolubility problems and sustain release improving the bioavailability. Zinc phthalocyanine, a hydrophobic photosensitizer with solubility problems, was loaded in PLA nanoparticles. Photosensitizer loaded in polymeric nanoparticles was produced with the following characteristics: size in the 200-300 nm range, negative zeta potential (-15 to -19 mV), low polydispersity index (< 0.1), satisfactory encapsulation efficiency (70-80%), low residual PVA, smooth surface and spherical shape. The photosensitizer release from nanoparticles was sustained and the kinetic followed Higuchi’s model. ZnPc loaded in polymeric nanoparticles exhibited higher phototoxicity than free photosensitizer. Phototoxicity of the ZnPc loaded in Resomer® R203 nanoparticles was improved for increasing photosensitizer concentration (1 to 4 μg/ml), light dose (10 to 30 J/cm<sup>2</sup> ) or incubation time (2 to 4 h). The phototoxicity of the zinc phthalocyanine was improved by encapsulation in nanoparticles and this nanocarrier is a promising delivery system for photodynamic therapy use.
format Articulo
Articulo
author Soares, Mariana V.
Lanzarini, Cíntia M.
Oliveira, Daniely S.
Ramos-Júnior, Paulo R.S.
Santos, Elizabete P.
Ricci-Júnior, Eduardo
author_facet Soares, Mariana V.
Lanzarini, Cíntia M.
Oliveira, Daniely S.
Ramos-Júnior, Paulo R.S.
Santos, Elizabete P.
Ricci-Júnior, Eduardo
author_sort Soares, Mariana V.
title Improving the phototoxicity of the zinc phthalocyanine by encapsulation in nanoparticles: preparation, characterization and phototherapy studies
title_short Improving the phototoxicity of the zinc phthalocyanine by encapsulation in nanoparticles: preparation, characterization and phototherapy studies
title_full Improving the phototoxicity of the zinc phthalocyanine by encapsulation in nanoparticles: preparation, characterization and phototherapy studies
title_fullStr Improving the phototoxicity of the zinc phthalocyanine by encapsulation in nanoparticles: preparation, characterization and phototherapy studies
title_full_unstemmed Improving the phototoxicity of the zinc phthalocyanine by encapsulation in nanoparticles: preparation, characterization and phototherapy studies
title_sort improving the phototoxicity of the zinc phthalocyanine by encapsulation in nanoparticles: preparation, characterization and phototherapy studies
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/7864
http://www.latamjpharm.org/resumenes/29/1/LAJOP_29_1_1_1.pdf
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