Technological development of hard capsules of sertraline hydrochloride

Fast release capsules, containing sertraline hydrochloride, pregelatinized maize starch and microcrystalline cellulose were formulated. For this purpose, different technological assays were elaborated being the formulation 2 selected as the better technological variant. Dry powders were filled int...

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Detalles Bibliográficos
Autores principales: Izquierdo, Adalberto C., Fernández C., Mirna, Castellanos Gil, Eddy
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
Medicamentos
hard gelatin capsule; sertraline; stability; validation of analytical methods
Farmacología
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7878
http://www.latamjpharm.org/resumenes/29/1/LAJOP_29_1_1_15.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7878
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Medicamentos
hard gelatin capsule; sertraline; stability; validation of analytical methods
Farmacología
spellingShingle Farmacia
Medicamentos
hard gelatin capsule; sertraline; stability; validation of analytical methods
Farmacología
Izquierdo, Adalberto C.
Fernández C., Mirna
Castellanos Gil, Eddy
Technological development of hard capsules of sertraline hydrochloride
topic_facet Farmacia
Medicamentos
hard gelatin capsule; sertraline; stability; validation of analytical methods
Farmacología
description Fast release capsules, containing sertraline hydrochloride, pregelatinized maize starch and microcrystalline cellulose were formulated. For this purpose, different technological assays were elaborated being the formulation 2 selected as the better technological variant. Dry powders were filled into hard gelatin capsules. From this formulation were derived capsules with satisfactory technological properties. The quantification of sertraline through HPLC UV detection method was validated for accuracy, precision, linearity and selectivity. The method was linear over the concentration range 0.5 to 0.75 mg/mL and was shown to be highly reproducible. It could be used, without any interference of capsule excipients, for determination of sertraline from solid dosage form. Hard capsules showed an adequate stability during 24 months demonstrating the feasibility from the process of production of this formulation. Parameters, f1 and f2, were used to confirm similarity of dissolution, in deaerated distilled water, of test formulation and capsules of Prosertin as reference product.
format Articulo
Articulo
author Izquierdo, Adalberto C.
Fernández C., Mirna
Castellanos Gil, Eddy
author_facet Izquierdo, Adalberto C.
Fernández C., Mirna
Castellanos Gil, Eddy
author_sort Izquierdo, Adalberto C.
title Technological development of hard capsules of sertraline hydrochloride
title_short Technological development of hard capsules of sertraline hydrochloride
title_full Technological development of hard capsules of sertraline hydrochloride
title_fullStr Technological development of hard capsules of sertraline hydrochloride
title_full_unstemmed Technological development of hard capsules of sertraline hydrochloride
title_sort technological development of hard capsules of sertraline hydrochloride
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/7878
http://www.latamjpharm.org/resumenes/29/1/LAJOP_29_1_1_15.pdf
work_keys_str_mv AT izquierdoadalbertoc technologicaldevelopmentofhardcapsulesofsertralinehydrochloride
AT fernandezcmirna technologicaldevelopmentofhardcapsulesofsertralinehydrochloride
AT castellanosgileddy technologicaldevelopmentofhardcapsulesofsertralinehydrochloride
bdutipo_str Repositorios
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