In vitro and in vivo antitumor effects of the flavonol glycosides isolated of Herissantia crispa (L.) Brizicky

This paper describes the cytotoxic and antitumoral activities of kaempferol 3-O-(6”-O-E-pcoumaroyl)-β-D-glucopyranoside (tiliroside), kaempferol 3,7-di-O-α-L-rhamnoside (dhiramnoside) and of the mixture of sitosteryl-3-O-β-D-glucopyranoside and stigmasteryl-3-O-β-D-glucopyranoside (GM) isolated of t...

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Autores principales:	Carvalho, Paulo R. C., Aguiar, Jaciana S., Matias, Wemerson N., Gomes, Roosevelt A., Teles, Yanna C.F., Souza, Maria de F. V., Medeiros, Paloma L., Silva, Eliete C., Silva, Teresinha G., Carneiro do Nascimento, Silene
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia antitumor activity; flavonol; glycosides; Herissantia crispa Plantas Medicinales Pruebas de Toxicidad
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8131 http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_1_6.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-8131
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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia antitumor activity; flavonol; glycosides; Herissantia crispa Plantas Medicinales Pruebas de Toxicidad
spellingShingle	Farmacia antitumor activity; flavonol; glycosides; Herissantia crispa Plantas Medicinales Pruebas de Toxicidad Carvalho, Paulo R. C. Aguiar, Jaciana S. Matias, Wemerson N. Gomes, Roosevelt A. Teles, Yanna C.F. Souza, Maria de F. V. Medeiros, Paloma L. Silva, Eliete C. Silva, Teresinha G. Carneiro do Nascimento, Silene In vitro and in vivo antitumor effects of the flavonol glycosides isolated of Herissantia crispa (L.) Brizicky
topic_facet	Farmacia antitumor activity; flavonol; glycosides; Herissantia crispa Plantas Medicinales Pruebas de Toxicidad
description	This paper describes the cytotoxic and antitumoral activities of kaempferol 3-O-(6”-O-E-pcoumaroyl)-β-D-glucopyranoside (tiliroside), kaempferol 3,7-di-O-α-L-rhamnoside (dhiramnoside) and of the mixture of sitosteryl-3-O-β-D-glucopyranoside and stigmasteryl-3-O-β-D-glucopyranoside (GM) isolated of the Herissantia crispa. The compounds did not present cytotoxic activity against NCI-H292, HEp-2 and KB cells. In vivo, dhiramnoside did not present significant inhibitory activity of the growth of sarcoma 180 when compared with the control group; however, tiliroside and GM-treated animals showed a high inhibition rate in the growth of the tumor. Tiliroside inhibits significantly the growth of the carcinoma of Ehrlich. In conclusion, tiliroside exhibited promising antitumor effects without an expressive toxicity.
format	Articulo Articulo
author	Carvalho, Paulo R. C. Aguiar, Jaciana S. Matias, Wemerson N. Gomes, Roosevelt A. Teles, Yanna C.F. Souza, Maria de F. V. Medeiros, Paloma L. Silva, Eliete C. Silva, Teresinha G. Carneiro do Nascimento, Silene
author_facet	Carvalho, Paulo R. C. Aguiar, Jaciana S. Matias, Wemerson N. Gomes, Roosevelt A. Teles, Yanna C.F. Souza, Maria de F. V. Medeiros, Paloma L. Silva, Eliete C. Silva, Teresinha G. Carneiro do Nascimento, Silene
author_sort	Carvalho, Paulo R. C.
title	In vitro and in vivo antitumor effects of the flavonol glycosides isolated of Herissantia crispa (L.) Brizicky
title_short	In vitro and in vivo antitumor effects of the flavonol glycosides isolated of Herissantia crispa (L.) Brizicky
title_full	In vitro and in vivo antitumor effects of the flavonol glycosides isolated of Herissantia crispa (L.) Brizicky
title_fullStr	In vitro and in vivo antitumor effects of the flavonol glycosides isolated of Herissantia crispa (L.) Brizicky
title_full_unstemmed	In vitro and in vivo antitumor effects of the flavonol glycosides isolated of Herissantia crispa (L.) Brizicky
title_sort	in vitro and in vivo antitumor effects of the flavonol glycosides isolated of herissantia crispa (l.) brizicky
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8131 http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_1_6.pdf
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In vitro and in vivo antitumor effects of the flavonol glycosides isolated of Herissantia crispa (L.) Brizicky

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