Evaluation of antidiarrhoeal and wound healing potentials of Ceratophyllum demersum Linn. whole plant in rats
The methanolic and aqueous extracts of whole plant of Ceratophyllum demersum were evaluated for antidiarrhoeal and wound healing potentials using experimental models in rats. Acute oral toxicity studies were performed according to the OECD 423 guidelines. Antidiarrhoeal activity at a dose of 250 and...
Guardado en:
| Autores principales: | , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8136 http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_1_12.pdf |
| Aporte de: |
| id |
I19-R120-10915-8136 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia antidiarrhoeal; ceratophyllum demersum; excision wound Plantas Medicinales Pruebas de Toxicidad |
| spellingShingle |
Farmacia antidiarrhoeal; ceratophyllum demersum; excision wound Plantas Medicinales Pruebas de Toxicidad Taranhalli, Ashok D. Kadam, Atul M. Karale, Sunil S. Warke, Yashodhan B. Evaluation of antidiarrhoeal and wound healing potentials of Ceratophyllum demersum Linn. whole plant in rats |
| topic_facet |
Farmacia antidiarrhoeal; ceratophyllum demersum; excision wound Plantas Medicinales Pruebas de Toxicidad |
| description |
The methanolic and aqueous extracts of whole plant of Ceratophyllum demersum were evaluated for antidiarrhoeal and wound healing potentials using experimental models in rats. Acute oral toxicity studies were performed according to the OECD 423 guidelines. Antidiarrhoeal activity at a dose of 250 and 500 mg/kg was evaluated in castor oil and magnesium sulphate induced diarrhoea in rats and the parameters studied were: total no. of faeces, no. of wet faeces, percentage inhibition of defecation and diarrhoeic drops. Wound healing activity of the both the extracts (5 % w/w ointment in simple ointment base) was evaluated in excision wound model and the parameters taken into account were percentage of wound closure and epithelialization time. Both the extracts at a dose of 500 mg/kg showed significant antidiarrhoeal and also showed significant wound healing activities (5 % w/w). It can be concluded that, the methanolic and aqueous extracts possesses antidiarrhoeal and wound healing activities, which support the use of whole plant in traditional medicine to treat the diarrhoea and wound. |
| format |
Articulo Articulo |
| author |
Taranhalli, Ashok D. Kadam, Atul M. Karale, Sunil S. Warke, Yashodhan B. |
| author_facet |
Taranhalli, Ashok D. Kadam, Atul M. Karale, Sunil S. Warke, Yashodhan B. |
| author_sort |
Taranhalli, Ashok D. |
| title |
Evaluation of antidiarrhoeal and wound healing potentials of Ceratophyllum demersum Linn. whole plant in rats |
| title_short |
Evaluation of antidiarrhoeal and wound healing potentials of Ceratophyllum demersum Linn. whole plant in rats |
| title_full |
Evaluation of antidiarrhoeal and wound healing potentials of Ceratophyllum demersum Linn. whole plant in rats |
| title_fullStr |
Evaluation of antidiarrhoeal and wound healing potentials of Ceratophyllum demersum Linn. whole plant in rats |
| title_full_unstemmed |
Evaluation of antidiarrhoeal and wound healing potentials of Ceratophyllum demersum Linn. whole plant in rats |
| title_sort |
evaluation of antidiarrhoeal and wound healing potentials of ceratophyllum demersum linn. whole plant in rats |
| publishDate |
2011 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8136 http://www.latamjpharm.org/resumenes/30/2/LAJOP_30_2_1_12.pdf |
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Repositorios |
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1764820488033402882 |