Compatibility studies of Olanzapine pre-formulated with excipients by thermal analysis: preliminary study

Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used to investigate drug-excipient interactions and, in consequence, their compatibility. For this purpose, binary mixtures of olanzapine drug substance and the excipients croscarmellose sodium, magnesium stearate and...

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Autores principales:	Marques, Lucas M. M., Medeiros, Maria G. F. de, Nunes, Lívio C. C., Citó, Antônia M.G.L., Lopes, José A. D., Souza, Alexandre A., Souza, Claide M. L.
Formato:	Articulo Comunicacion
Lenguaje:	Inglés
Publicado:	2011
Materias:	Farmacia Excipientes Farmacéuticos compatibility; DSC; excipient; olanzapine; TGA; thermal analysis Técnicas de Química Analítica
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/8283 http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_2_2.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Excipientes Farmacéuticos compatibility; DSC; excipient; olanzapine; TGA; thermal analysis Técnicas de Química Analítica
spellingShingle	Farmacia Excipientes Farmacéuticos compatibility; DSC; excipient; olanzapine; TGA; thermal analysis Técnicas de Química Analítica Marques, Lucas M. M. Medeiros, Maria G. F. de Nunes, Lívio C. C. Citó, Antônia M.G.L. Lopes, José A. D. Souza, Alexandre A. Souza, Claide M. L. Compatibility studies of Olanzapine pre-formulated with excipients by thermal analysis: preliminary study
topic_facet	Farmacia Excipientes Farmacéuticos compatibility; DSC; excipient; olanzapine; TGA; thermal analysis Técnicas de Química Analítica
description	Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used to investigate drug-excipient interactions and, in consequence, their compatibility. For this purpose, binary mixtures of olanzapine drug substance and the excipients croscarmellose sodium, magnesium stearate and microcrystalline cellulose, were prepared and analysed. By the analysis of the binary mixtures DSC and TG curves it were observed changes on the temperature and enthalpy values of the drug melting and decomposition peak, with the likely formation of intermediate substances.
format	Articulo Comunicacion
author	Marques, Lucas M. M. Medeiros, Maria G. F. de Nunes, Lívio C. C. Citó, Antônia M.G.L. Lopes, José A. D. Souza, Alexandre A. Souza, Claide M. L.
author_facet	Marques, Lucas M. M. Medeiros, Maria G. F. de Nunes, Lívio C. C. Citó, Antônia M.G.L. Lopes, José A. D. Souza, Alexandre A. Souza, Claide M. L.
author_sort	Marques, Lucas M. M.
title	Compatibility studies of Olanzapine pre-formulated with excipients by thermal analysis: preliminary study
title_short	Compatibility studies of Olanzapine pre-formulated with excipients by thermal analysis: preliminary study
title_full	Compatibility studies of Olanzapine pre-formulated with excipients by thermal analysis: preliminary study
title_fullStr	Compatibility studies of Olanzapine pre-formulated with excipients by thermal analysis: preliminary study
title_full_unstemmed	Compatibility studies of Olanzapine pre-formulated with excipients by thermal analysis: preliminary study
title_sort	compatibility studies of olanzapine pre-formulated with excipients by thermal analysis: preliminary study
publishDate	2011
url	http://sedici.unlp.edu.ar/handle/10915/8283 http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_2_2.pdf
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Compatibility studies of Olanzapine pre-formulated with excipients by thermal analysis: preliminary study

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