Short and stereoselective synthesis of α-methylene-β-hydroxy-γ-butyrolactone diastereomers : Structures revised by theoretical investigations
A short synthetic approach allowed the preparation, in two steps, of (3S,4R)- and (3R,4R)-2- methylene-3-hydroxy-4-(hydroxymethyl)-γ-butyrolactones from 2,3-O-(3-pentylidene)-D-glyceraldehyde, with overall yields of 32 % and 9 %, respectively. The structure of these γ-butyrolactones was revised by e...
Guardado en:
| Autores principales: | , , , , |
|---|---|
| Formato: | Articulo Comunicacion |
| Lenguaje: | Inglés |
| Publicado: |
2011
|
| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/8356 http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_2_8.pdf |
| Aporte de: |
| id |
I19-R120-10915-8356 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia antitumoral agents; BLYP/6-31G* theoretical calculation; γ-butyrolactones |
| spellingShingle |
Farmacia antitumoral agents; BLYP/6-31G* theoretical calculation; γ-butyrolactones Díaz, Gaspar Carvalho, Gláucia S. Soares, Flávia R. F. Alcântara, Antônio F. de C. Diaz, Marisa A. N. Short and stereoselective synthesis of α-methylene-β-hydroxy-γ-butyrolactone diastereomers : Structures revised by theoretical investigations |
| topic_facet |
Farmacia antitumoral agents; BLYP/6-31G* theoretical calculation; γ-butyrolactones |
| description |
A short synthetic approach allowed the preparation, in two steps, of (3S,4R)- and (3R,4R)-2- methylene-3-hydroxy-4-(hydroxymethyl)-γ-butyrolactones from 2,3-O-(3-pentylidene)-D-glyceraldehyde, with overall yields of 32 % and 9 %, respectively. The structure of these γ-butyrolactones was revised by experimental and theoretical investigations. |
| format |
Articulo Comunicacion |
| author |
Díaz, Gaspar Carvalho, Gláucia S. Soares, Flávia R. F. Alcântara, Antônio F. de C. Diaz, Marisa A. N. |
| author_facet |
Díaz, Gaspar Carvalho, Gláucia S. Soares, Flávia R. F. Alcântara, Antônio F. de C. Diaz, Marisa A. N. |
| author_sort |
Díaz, Gaspar |
| title |
Short and stereoselective synthesis of α-methylene-β-hydroxy-γ-butyrolactone diastereomers : Structures revised by theoretical investigations |
| title_short |
Short and stereoselective synthesis of α-methylene-β-hydroxy-γ-butyrolactone diastereomers : Structures revised by theoretical investigations |
| title_full |
Short and stereoselective synthesis of α-methylene-β-hydroxy-γ-butyrolactone diastereomers : Structures revised by theoretical investigations |
| title_fullStr |
Short and stereoselective synthesis of α-methylene-β-hydroxy-γ-butyrolactone diastereomers : Structures revised by theoretical investigations |
| title_full_unstemmed |
Short and stereoselective synthesis of α-methylene-β-hydroxy-γ-butyrolactone diastereomers : Structures revised by theoretical investigations |
| title_sort |
short and stereoselective synthesis of α-methylene-β-hydroxy-γ-butyrolactone diastereomers : structures revised by theoretical investigations |
| publishDate |
2011 |
| url |
http://sedici.unlp.edu.ar/handle/10915/8356 http://www.latamjpharm.org/resumenes/30/8/LAJOP_30_8_2_8.pdf |
| work_keys_str_mv |
AT diazgaspar shortandstereoselectivesynthesisofamethylenebhydroxygbutyrolactonediastereomersstructuresrevisedbytheoreticalinvestigations AT carvalhoglaucias shortandstereoselectivesynthesisofamethylenebhydroxygbutyrolactonediastereomersstructuresrevisedbytheoreticalinvestigations AT soaresflaviarf shortandstereoselectivesynthesisofamethylenebhydroxygbutyrolactonediastereomersstructuresrevisedbytheoreticalinvestigations AT alcantaraantoniofdec shortandstereoselectivesynthesisofamethylenebhydroxygbutyrolactonediastereomersstructuresrevisedbytheoreticalinvestigations AT diazmarisaan shortandstereoselectivesynthesisofamethylenebhydroxygbutyrolactonediastereomersstructuresrevisedbytheoreticalinvestigations |
| bdutipo_str |
Repositorios |
| _version_ |
1764820488768454657 |