New validated RP-UPLC method for determination of aripiprazole assay in aripiprazole tablets

A simple, economic and time-efficient, isocratic reverse-phase ultra performance liquid chromatographic (RP-UPLC) method has been developed to analyze aripiprazole in tablets. Successful chromatographic elution and quantification of the drug was achieved on a Waters Symmetry C18, 100 mm x 4.6mm, 3.5...

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Autores principales: Negi, Bhawana, Bansal, Ruchi, Singh, Dhirendra P., Singh, Lokesh K.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Farmacia
Estudios de Validación
Agentes Antipsicóticos
Cromatografía de Fase Inversa
Cromatografía Liquida
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/8410
http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_22.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-8410
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Estudios de Validación
Agentes Antipsicóticos
Cromatografía de Fase Inversa
Cromatografía Liquida
spellingShingle Farmacia
Estudios de Validación
Agentes Antipsicóticos
Cromatografía de Fase Inversa
Cromatografía Liquida
Negi, Bhawana
Bansal, Ruchi
Singh, Dhirendra P.
Singh, Lokesh K.
New validated RP-UPLC method for determination of aripiprazole assay in aripiprazole tablets
topic_facet Farmacia
Estudios de Validación
Agentes Antipsicóticos
Cromatografía de Fase Inversa
Cromatografía Liquida
description A simple, economic and time-efficient, isocratic reverse-phase ultra performance liquid chromatographic (RP-UPLC) method has been developed to analyze aripiprazole in tablets. Successful chromatographic elution and quantification of the drug was achieved on a Waters Symmetry C18, 100 mm x 4.6mm, 3.5 μm column, UV detection at 220 nm with a isocratic mobile phase comprising a mixture of component A (pH 2.5, phosphate buffer) and component B (methanol and acetonitrile (1:1, v/v) in the ratio of 45:55 (v/v). The flow rate was 1.0 mL/min. The method was validated for specificity, precision, linearity, accuracy, range, stability in analytical solution, robustness and system suitability. The linearity concentration range was 5.4-67.8 μg/mL with the correlation coefficient of 0.9997. Total elution time was about 6 min which allowed quantification of more than 100 samples per day.
format Articulo
Articulo
author Negi, Bhawana
Bansal, Ruchi
Singh, Dhirendra P.
Singh, Lokesh K.
author_facet Negi, Bhawana
Bansal, Ruchi
Singh, Dhirendra P.
Singh, Lokesh K.
author_sort Negi, Bhawana
title New validated RP-UPLC method for determination of aripiprazole assay in aripiprazole tablets
title_short New validated RP-UPLC method for determination of aripiprazole assay in aripiprazole tablets
title_full New validated RP-UPLC method for determination of aripiprazole assay in aripiprazole tablets
title_fullStr New validated RP-UPLC method for determination of aripiprazole assay in aripiprazole tablets
title_full_unstemmed New validated RP-UPLC method for determination of aripiprazole assay in aripiprazole tablets
title_sort new validated rp-uplc method for determination of aripiprazole assay in aripiprazole tablets
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/8410
http://www.latamjpharm.org/resumenes/30/10/LAJOP_30_10_1_22.pdf
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