Enterococcus faecalis virulence regulator FsrA binding to target promoters

The FsrABDC signal transduction system is a major virulence regulator in Enterococcus faecalis. The FsrC sensor histidine kinase, upon activation by the gelatinase biosynthesis-activating pheromone (GBAP) peptide encoded by the fsrBD genes, phosphorylates the FsrA response regulator required for the...

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Detalles Bibliográficos
Autores principales: Del Papa, María Florencia, Perego, Marta
Formato: Articulo
Lenguaje:Inglés
Publicado: 2011
Materias:
Biología
Biotecnología
Virulence regulator
Virulencia
Enterococcus faecalis
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/84210
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-84210
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Biotecnología
Virulence regulator
Virulencia
Enterococcus faecalis
spellingShingle Biología
Biotecnología
Virulence regulator
Virulencia
Enterococcus faecalis
Del Papa, María Florencia
Perego, Marta
Enterococcus faecalis virulence regulator FsrA binding to target promoters
topic_facet Biología
Biotecnología
Virulence regulator
Virulencia
Enterococcus faecalis
description The FsrABDC signal transduction system is a major virulence regulator in Enterococcus faecalis. The FsrC sensor histidine kinase, upon activation by the gelatinase biosynthesis-activating pheromone (GBAP) peptide encoded by the fsrBD genes, phosphorylates the FsrA response regulator required for the transcription of the fsrBDC and the gelE-sprE genes from the fsrB promoter and the gelE promoter, respectively. FsrA belongs to the LytTR family of proteins, which includes other virulence regulators, such as AgrA of Staphylococcus aureus, AlgR of Pseudomonas aeruginosa, and VirR of Clostridium perfringens. The LytTR DNA-binding domain that characterizes these proteins generally binds to two imperfect direct repeats separated by a number of bases that place the repeats on the same face of the DNA helix. In this study, we demonstrated that FsrA also binds to two imperfect direct repeats separated by 13 bp, based on the consensus sequence of FsrA, T/AT/CAA/GG GAA/G, which is consistent with the binding characteristics of LytTR domains.
format Articulo
Articulo
author Del Papa, María Florencia
Perego, Marta
author_facet Del Papa, María Florencia
Perego, Marta
author_sort Del Papa, María Florencia
title Enterococcus faecalis virulence regulator FsrA binding to target promoters
title_short Enterococcus faecalis virulence regulator FsrA binding to target promoters
title_full Enterococcus faecalis virulence regulator FsrA binding to target promoters
title_fullStr Enterococcus faecalis virulence regulator FsrA binding to target promoters
title_full_unstemmed Enterococcus faecalis virulence regulator FsrA binding to target promoters
title_sort enterococcus faecalis virulence regulator fsra binding to target promoters
publishDate 2011
url http://sedici.unlp.edu.ar/handle/10915/84210
work_keys_str_mv AT delpapamariaflorencia enterococcusfaecalisvirulenceregulatorfsrabindingtotargetpromoters
AT peregomarta enterococcusfaecalisvirulenceregulatorfsrabindingtotargetpromoters
bdutipo_str Repositorios
_version_ 1764820488474853380

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