Mitochondrial reactive oxygen species (ROS) as signaling molecules of intracellular pathways triggered by the cardiac renin-angiotensin II-aldosterone system (RAAS)

Mitochondria represent major sources of basal reactive oxygen species (ROS) production of the cardiomyocyte. The role of ROS as signaling molecules that mediate different intracellular pathways has gained increasing interest among physiologists in the last years. In our lab, we have been studying th...

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Detalles Bibliográficos
Autores principales:	De Giusti, Verónica Celeste, Caldiz, Claudia Irma, Ennis, Irene Lucía, Pérez, Néstor Gustavo, Cingolani, Horacio Eugenio, Aiello, Ernesto Alejandro
Formato:	Articulo Revision
Lenguaje:	Inglés
Publicado:	2013
Materias:	Ciencias Médicas Cardiac myocyte Reactive oxygen species Second messenger systems Sodium-bicarbonate symporters Sodium-hydrogen antiporter
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/85467
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-85467
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Médicas Cardiac myocyte Reactive oxygen species Second messenger systems Sodium-bicarbonate symporters Sodium-hydrogen antiporter
spellingShingle	Ciencias Médicas Cardiac myocyte Reactive oxygen species Second messenger systems Sodium-bicarbonate symporters Sodium-hydrogen antiporter De Giusti, Verónica Celeste Caldiz, Claudia Irma Ennis, Irene Lucía Pérez, Néstor Gustavo Cingolani, Horacio Eugenio Aiello, Ernesto Alejandro Mitochondrial reactive oxygen species (ROS) as signaling molecules of intracellular pathways triggered by the cardiac renin-angiotensin II-aldosterone system (RAAS)
topic_facet	Ciencias Médicas Cardiac myocyte Reactive oxygen species Second messenger systems Sodium-bicarbonate symporters Sodium-hydrogen antiporter
description	Mitochondria represent major sources of basal reactive oxygen species (ROS) production of the cardiomyocyte. The role of ROS as signaling molecules that mediate different intracellular pathways has gained increasing interest among physiologists in the last years. In our lab, we have been studying the participation of mitochondrial ROS in the intracellular pathways triggered by the renin-angiotensin II-aldosterone system (RAAS) in the myocardium during the past few years. We have demonstrated that acute activation of cardiac RAAS induces mitochondrial ATP-dependent potassium channel (mitoK<SUB>ATP</SUB>) opening with the consequent enhanced production of mitochondrial ROS. These oxidant molecules, in turn, activate membrane transporters, as sodium/hydrogen exchanger (NHE-1) and sodium/bicarbonate cotransporter (NBC) via the stimulation of the ROS-sensitive MAPK cascade. The stimulation of such effectors leads to an increase in cardiac contractility. In addition, it is feasible to suggest that a sustained enhanced production of mitochondrial ROS induced by chronic cardiac RAAS, and hence, chronic NHE-1 and NBC stimulation, would also result in the development of cardiac hypertrophy.
format	Articulo Revision
author	De Giusti, Verónica Celeste Caldiz, Claudia Irma Ennis, Irene Lucía Pérez, Néstor Gustavo Cingolani, Horacio Eugenio Aiello, Ernesto Alejandro
author_facet	De Giusti, Verónica Celeste Caldiz, Claudia Irma Ennis, Irene Lucía Pérez, Néstor Gustavo Cingolani, Horacio Eugenio Aiello, Ernesto Alejandro
author_sort	De Giusti, Verónica Celeste
title	Mitochondrial reactive oxygen species (ROS) as signaling molecules of intracellular pathways triggered by the cardiac renin-angiotensin II-aldosterone system (RAAS)
title_short	Mitochondrial reactive oxygen species (ROS) as signaling molecules of intracellular pathways triggered by the cardiac renin-angiotensin II-aldosterone system (RAAS)
title_full	Mitochondrial reactive oxygen species (ROS) as signaling molecules of intracellular pathways triggered by the cardiac renin-angiotensin II-aldosterone system (RAAS)
title_fullStr	Mitochondrial reactive oxygen species (ROS) as signaling molecules of intracellular pathways triggered by the cardiac renin-angiotensin II-aldosterone system (RAAS)
title_full_unstemmed	Mitochondrial reactive oxygen species (ROS) as signaling molecules of intracellular pathways triggered by the cardiac renin-angiotensin II-aldosterone system (RAAS)
title_sort	mitochondrial reactive oxygen species (ros) as signaling molecules of intracellular pathways triggered by the cardiac renin-angiotensin ii-aldosterone system (raas)
publishDate	2013
url	http://sedici.unlp.edu.ar/handle/10915/85467
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Mitochondrial reactive oxygen species (ROS) as signaling molecules of intracellular pathways triggered by the cardiac renin-angiotensin II-aldosterone system (RAAS)

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