Differential Spatiotemporal Patterns of Galectin Expression are a Hallmark of Endotheliochorial Placentation

Problem: Galectins influence the progress of pregnancy by regulating key processes associated with embryo-maternal cross talk, including angiogenesis and placentation. Galectin family members exert multiple roles in the context of hemochorial and epitheliochorial placentation; however, the galectin...

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Autores principales: Conrad, Melanie L., Freitag, Nancy, Diessler, Mónica Elizabeth, Hernández, Rocío, Barrientos, Gabriela, Rose, Matthias, Casas, Luciano Agustín, Barbeito, Claudio Gustavo, Blois, Sandra M.
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2016
Materias:
Ciencias Veterinarias
Canine
endotheliochorial
feline
galectins
placenta
pregnancy
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/86265
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-86265
record_format dspace
spelling I19-R120-10915-862652024-10-03T18:59:11Z http://sedici.unlp.edu.ar/handle/10915/86265 Differential Spatiotemporal Patterns of Galectin Expression are a Hallmark of Endotheliochorial Placentation Conrad, Melanie L. Freitag, Nancy Diessler, Mónica Elizabeth Hernández, Rocío Barrientos, Gabriela Rose, Matthias Casas, Luciano Agustín Barbeito, Claudio Gustavo Blois, Sandra M. 2016 2019-11-28T14:36:25Z en Ciencias Veterinarias Canine endotheliochorial feline galectins placenta pregnancy Problem: Galectins influence the progress of pregnancy by regulating key processes associated with embryo-maternal cross talk, including angiogenesis and placentation. Galectin family members exert multiple roles in the context of hemochorial and epitheliochorial placentation; however, the galectin prolife in endotheliochorial placenta remains to be investigated. Method of study: Here, we used immunohistochemistry to analyze galectin (gal)-1, gal-3 and gal-9 expression during early and late endotheliochorial placentation in two different species (dogs and cats). Results: We found that during early feline gestation, all three galectin members were more strongly expressed on trophoblast and maternal vessels compared to the decidua. This was accompanied by an overall decrease of gal-1, gal-3 and gal-9 expressions in late feline gestation. In canine early pregnancy, we observed that gal-1 and gal-9 were expressed strongly in cytotrophoblast (CTB) cells compared to gal-3, and no galectin expression was observed in syncytiotrophoblast (STB) cells. Progression of canine gestation was accompanied by increased gal-1 and gal-3 expressions on STB cells, whereas gal-9 expression remained similar in CTB and STB. Conclusion: These data suggest that both the maternal and fetal compartments are characterized by a spatiotemporal regulation of galectin expression during endotheliochorial placentation. This strongly suggests the involvement of the galectin family in important developmental processes during gestation including immunemodulation, trophoblast invasion and angiogenesis. A conserved functional role for galectins during mammalian placental development emerges from these studies. Facultad de Ciencias Veterinarias Articulo Revision http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf 317-325
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Canine
endotheliochorial
feline
galectins
placenta
pregnancy
spellingShingle Ciencias Veterinarias
Canine
endotheliochorial
feline
galectins
placenta
pregnancy
Conrad, Melanie L.
Freitag, Nancy
Diessler, Mónica Elizabeth
Hernández, Rocío
Barrientos, Gabriela
Rose, Matthias
Casas, Luciano Agustín
Barbeito, Claudio Gustavo
Blois, Sandra M.
Differential Spatiotemporal Patterns of Galectin Expression are a Hallmark of Endotheliochorial Placentation
topic_facet Ciencias Veterinarias
Canine
endotheliochorial
feline
galectins
placenta
pregnancy
description Problem: Galectins influence the progress of pregnancy by regulating key processes associated with embryo-maternal cross talk, including angiogenesis and placentation. Galectin family members exert multiple roles in the context of hemochorial and epitheliochorial placentation; however, the galectin prolife in endotheliochorial placenta remains to be investigated. Method of study: Here, we used immunohistochemistry to analyze galectin (gal)-1, gal-3 and gal-9 expression during early and late endotheliochorial placentation in two different species (dogs and cats). Results: We found that during early feline gestation, all three galectin members were more strongly expressed on trophoblast and maternal vessels compared to the decidua. This was accompanied by an overall decrease of gal-1, gal-3 and gal-9 expressions in late feline gestation. In canine early pregnancy, we observed that gal-1 and gal-9 were expressed strongly in cytotrophoblast (CTB) cells compared to gal-3, and no galectin expression was observed in syncytiotrophoblast (STB) cells. Progression of canine gestation was accompanied by increased gal-1 and gal-3 expressions on STB cells, whereas gal-9 expression remained similar in CTB and STB. Conclusion: These data suggest that both the maternal and fetal compartments are characterized by a spatiotemporal regulation of galectin expression during endotheliochorial placentation. This strongly suggests the involvement of the galectin family in important developmental processes during gestation including immunemodulation, trophoblast invasion and angiogenesis. A conserved functional role for galectins during mammalian placental development emerges from these studies.
format Articulo
Revision
author Conrad, Melanie L.
Freitag, Nancy
Diessler, Mónica Elizabeth
Hernández, Rocío
Barrientos, Gabriela
Rose, Matthias
Casas, Luciano Agustín
Barbeito, Claudio Gustavo
Blois, Sandra M.
author_facet Conrad, Melanie L.
Freitag, Nancy
Diessler, Mónica Elizabeth
Hernández, Rocío
Barrientos, Gabriela
Rose, Matthias
Casas, Luciano Agustín
Barbeito, Claudio Gustavo
Blois, Sandra M.
author_sort Conrad, Melanie L.
title Differential Spatiotemporal Patterns of Galectin Expression are a Hallmark of Endotheliochorial Placentation
title_short Differential Spatiotemporal Patterns of Galectin Expression are a Hallmark of Endotheliochorial Placentation
title_full Differential Spatiotemporal Patterns of Galectin Expression are a Hallmark of Endotheliochorial Placentation
title_fullStr Differential Spatiotemporal Patterns of Galectin Expression are a Hallmark of Endotheliochorial Placentation
title_full_unstemmed Differential Spatiotemporal Patterns of Galectin Expression are a Hallmark of Endotheliochorial Placentation
title_sort differential spatiotemporal patterns of galectin expression are a hallmark of endotheliochorial placentation
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/86265
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