Is ghrelin synthesized in the central nervous system?

Ghrelin is an octanoylated peptide that acts via its specific receptor, the growth hormone secretagogue receptor type 1a (GHSR-1a), and regulates a vast variety of physiological functions. It is well established that ghrelin is predominantly synthesized by a distinct population of endocrine cells lo...

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Detalles Bibliográficos
Autores principales: Cabral, Agustina Soledad, López Soto, Eduardo Javier, Epelbaum, Jacques, Perelló, Mario
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2017
Materias:
Ciencias Exactas
Acyl-ghrelin
Brain
Neuron
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/87354
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-87354
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Acyl-ghrelin
Brain
Neuron
spellingShingle Ciencias Exactas
Acyl-ghrelin
Brain
Neuron
Cabral, Agustina Soledad
López Soto, Eduardo Javier
Epelbaum, Jacques
Perelló, Mario
Is ghrelin synthesized in the central nervous system?
topic_facet Ciencias Exactas
Acyl-ghrelin
Brain
Neuron
description Ghrelin is an octanoylated peptide that acts via its specific receptor, the growth hormone secretagogue receptor type 1a (GHSR-1a), and regulates a vast variety of physiological functions. It is well established that ghrelin is predominantly synthesized by a distinct population of endocrine cells located within the gastric oxyntic mucosa. In addition, some studies have reported that ghrelin could also be synthesized in some brain regions, such as the hypothalamus. However, evidences of neuronal production of ghrelin have been inconsistent and, as a consequence, it is still as a matter of debate if ghrelin can be centrally produced. Here, we provide a comprehensive review and discussion of the data supporting, or not, the notion that the mammalian central nervous system can synthetize ghrelin. We conclude that no irrefutable and reproducible evidence exists supporting the notion that ghrelin is synthetized, at physiologically relevant levels, in the central nervous system of adult mammals.
format Articulo
Revision
author Cabral, Agustina Soledad
López Soto, Eduardo Javier
Epelbaum, Jacques
Perelló, Mario
author_facet Cabral, Agustina Soledad
López Soto, Eduardo Javier
Epelbaum, Jacques
Perelló, Mario
author_sort Cabral, Agustina Soledad
title Is ghrelin synthesized in the central nervous system?
title_short Is ghrelin synthesized in the central nervous system?
title_full Is ghrelin synthesized in the central nervous system?
title_fullStr Is ghrelin synthesized in the central nervous system?
title_full_unstemmed Is ghrelin synthesized in the central nervous system?
title_sort is ghrelin synthesized in the central nervous system?
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/87354
work_keys_str_mv AT cabralagustinasoledad isghrelinsynthesizedinthecentralnervoussystem
AT lopezsotoeduardojavier isghrelinsynthesizedinthecentralnervoussystem
AT epelbaumjacques isghrelinsynthesizedinthecentralnervoussystem
AT perellomario isghrelinsynthesizedinthecentralnervoussystem
bdutipo_str Repositorios
_version_ 1764820489898819586

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