Resveratrol enhancement staphylococcus aureus survival under levofloxacin and photodynamic treatments

Reactive oxygen species (ROS) are an efficient tool to eradicate micro-organisms owing to the capacity of these species to damage almost all types of biomolecules and to kill cells. The increase in mechanisms of antimicrobial resistance has led to the exploration of new strategies to eliminate micro...

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Autores principales: Gaspar Tosato, Maira, Schilardi, Patricia Laura, Fernández Lorenzo de Mele, Mónica Alicia, Thomas, Andrés Héctor, Miñán, Alejandro, Lorente, Carolina
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2017
Materias:
Química
Antibiotics
Levofloxacin
Photodynamic inactivation
Resveratrol
Staphylococcus aureus
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/99501
https://ri.conicet.gov.ar/11336/63923
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-99501
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Antibiotics
Levofloxacin
Photodynamic inactivation
Resveratrol
Staphylococcus aureus
spellingShingle Química
Antibiotics
Levofloxacin
Photodynamic inactivation
Resveratrol
Staphylococcus aureus
Gaspar Tosato, Maira
Schilardi, Patricia Laura
Fernández Lorenzo de Mele, Mónica Alicia
Thomas, Andrés Héctor
Miñán, Alejandro
Lorente, Carolina
Resveratrol enhancement staphylococcus aureus survival under levofloxacin and photodynamic treatments
topic_facet Química
Antibiotics
Levofloxacin
Photodynamic inactivation
Resveratrol
Staphylococcus aureus
description Reactive oxygen species (ROS) are an efficient tool to eradicate micro-organisms owing to the capacity of these species to damage almost all types of biomolecules and to kill cells. The increase in mechanisms of antimicrobial resistance has led to the exploration of new strategies to eliminate micro-organisms that involve the production of ROS such as superoxide anion (O2 •–) and hydrogen peroxide (H2O2). ROS are produced during several antimicrobial treatments, including antibiotic and photodynamic therapies. Among the natural antioxidants, resveratrol (RSV) is efficient at preventing damage from ROS, and every day more people incorporate it as a dietary or cosmetic supplement. However, the consequences of the administration of RSV during antimicrobial treatment are unknown. To investigate possible antagonistic or synergistic effects of RSV during antibiotic therapy (levofloxacin) or photodynamic therapy (visible radiation and methylene blue), killing of planktonic Staphylococcus aureus bacteria was evaluated in the presence of RSV. The results showed that the antimicrobial capacity of these therapies is significantly diminished when levofloxacin or methylene blue are co-administered with RSV, indicating that consumption of RSV during antimicrobial treatment must be, at least, cautioned. Moreover, considering the ROS antimicrobial activity of antibacterial agents, the topical addition of RSV may also affect the control of pathogens of the human body. The results presented in this article highlight the importance of the evaluation of possible antagonistic effects when an antimicrobial agent with ROS-mediated action is co-administrated with RSV.
format Articulo
Preprint
author Gaspar Tosato, Maira
Schilardi, Patricia Laura
Fernández Lorenzo de Mele, Mónica Alicia
Thomas, Andrés Héctor
Miñán, Alejandro
Lorente, Carolina
author_facet Gaspar Tosato, Maira
Schilardi, Patricia Laura
Fernández Lorenzo de Mele, Mónica Alicia
Thomas, Andrés Héctor
Miñán, Alejandro
Lorente, Carolina
author_sort Gaspar Tosato, Maira
title Resveratrol enhancement staphylococcus aureus survival under levofloxacin and photodynamic treatments
title_short Resveratrol enhancement staphylococcus aureus survival under levofloxacin and photodynamic treatments
title_full Resveratrol enhancement staphylococcus aureus survival under levofloxacin and photodynamic treatments
title_fullStr Resveratrol enhancement staphylococcus aureus survival under levofloxacin and photodynamic treatments
title_full_unstemmed Resveratrol enhancement staphylococcus aureus survival under levofloxacin and photodynamic treatments
title_sort resveratrol enhancement staphylococcus aureus survival under levofloxacin and photodynamic treatments
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/99501
https://ri.conicet.gov.ar/11336/63923
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