Impact of Neonatal Manipulation of Androgen Receptor Function on Endocrine-Metabolic Programming in the Juvenile Female Rat

The impact of neonatal androgen receptor (AR) stimulation/blockage, due to testosterone propionate (TP)/AR antagonist treatment, on individual anthropometry and neuroendocrine-metabolic function was evaluated in the juvenile female rat. Pups (age 5 days) were s.c. injected with TP (1.25 mg), flutami...

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Autores principales: Ongaro Gambino, Luisina, Giovambattista, Andrés, Spinedi, Eduardo Julio
Formato: Articulo
Lenguaje:Inglés
Publicado: 2013
Materias:
Bioquímica
Ciencias Médicas
Testosterone
Ovary
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/99859
https://ri.conicet.gov.ar/11336/24620
https://www.hindawi.com/journals/isrn/2013/181950/
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-99859
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Bioquímica
Ciencias Médicas
Testosterone
Ovary
spellingShingle Bioquímica
Ciencias Médicas
Testosterone
Ovary
Ongaro Gambino, Luisina
Giovambattista, Andrés
Spinedi, Eduardo Julio
Impact of Neonatal Manipulation of Androgen Receptor Function on Endocrine-Metabolic Programming in the Juvenile Female Rat
topic_facet Bioquímica
Ciencias Médicas
Testosterone
Ovary
description The impact of neonatal androgen receptor (AR) stimulation/blockage, due to testosterone propionate (TP)/AR antagonist treatment, on individual anthropometry and neuroendocrine-metabolic function was evaluated in the juvenile female rat. Pups (age 5 days) were s.c. injected with TP (1.25 mg), flutamide (F; 1.75 mg), and TP + F or vehicle (control, CT) and studied on day 30 of age. Body weight (BW), parametrial adipose tissue (PMAT) mass, food intake, adipoinsular axis, and steroidogenic functions were examined. Opposite to TP-rats, F-treated rats developed hypophagia, grew slowly (BW and PMAT), and displayed heightened peripheral insulin sensitivity. These F effects were abrogated in TP + F animals. Accordingly, TP rats displayed hyperleptinemia, an effect fully prevented by F cotreatment. Finally, androgen-treated animals bore an irreversible ovarian dysfunction (reduced circulating levels of 17HOP4 and ovary 17HOP4 content and P450c17 mRNA abundance). These data indicate that early stimulation of AR enhanced energy store, blockage of AR activity resulted in some beneficial metabolic effects, and neonatally androgenized rats developed a severe ovarian dysfunction. Our study highlights the important role of AR in the early organizational programming of metabolic and neuroendocrine functions.
format Articulo
Articulo
author Ongaro Gambino, Luisina
Giovambattista, Andrés
Spinedi, Eduardo Julio
author_facet Ongaro Gambino, Luisina
Giovambattista, Andrés
Spinedi, Eduardo Julio
author_sort Ongaro Gambino, Luisina
title Impact of Neonatal Manipulation of Androgen Receptor Function on Endocrine-Metabolic Programming in the Juvenile Female Rat
title_short Impact of Neonatal Manipulation of Androgen Receptor Function on Endocrine-Metabolic Programming in the Juvenile Female Rat
title_full Impact of Neonatal Manipulation of Androgen Receptor Function on Endocrine-Metabolic Programming in the Juvenile Female Rat
title_fullStr Impact of Neonatal Manipulation of Androgen Receptor Function on Endocrine-Metabolic Programming in the Juvenile Female Rat
title_full_unstemmed Impact of Neonatal Manipulation of Androgen Receptor Function on Endocrine-Metabolic Programming in the Juvenile Female Rat
title_sort impact of neonatal manipulation of androgen receptor function on endocrine-metabolic programming in the juvenile female rat
publishDate 2013
url http://sedici.unlp.edu.ar/handle/10915/99859
https://ri.conicet.gov.ar/11336/24620
https://www.hindawi.com/journals/isrn/2013/181950/
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AT giovambattistaandres impactofneonatalmanipulationofandrogenreceptorfunctiononendocrinemetabolicprogramminginthejuvenilefemalerat
AT spinedieduardojulio impactofneonatalmanipulationofandrogenreceptorfunctiononendocrinemetabolicprogramminginthejuvenilefemalerat
bdutipo_str Repositorios
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