Behavioral tagging underlies memory reconsolidation

"Memory reconsolidation occurs when a retrieving event destabilizes transiently a consolidated memory, triggering thereby a new process of restabilization that ensures memory persistence. Although this phenomenon has received wide attention, the effect of new information cooccurring with the re...

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Autores principales: Rabinovich Orlandi, Iván, Fullio, Camila L., Schroeder, Matías Nicolás, Giurfa, Martin, Ballarini, Fabricio, Moncada, Diego
Formato: Artículos de Publicaciones Periódicas acceptedVersion
Lenguaje:Inglés
Publicado: info
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CONSOLIDACION DE LA MEMORIA
ETIQUETADO CONDUCTUAL
Acceso en línea:http://ri.itba.edu.ar/handle/123456789/3217
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Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) de Instituto Tecnológico de Buenos Aires (ITBA)
id I32-R138-123456789-3217
record_format dspace
spelling I32-R138-123456789-32172022-12-07T13:07:04Z Behavioral tagging underlies memory reconsolidation Rabinovich Orlandi, Iván Fullio, Camila L. Schroeder, Matías Nicolás Giurfa, Martin Ballarini, Fabricio Moncada, Diego CONSOLIDACION DE LA MEMORIA ETIQUETADO CONDUCTUAL "Memory reconsolidation occurs when a retrieving event destabilizes transiently a consolidated memory, triggering thereby a new process of restabilization that ensures memory persistence. Although this phenomenon has received wide attention, the effect of new information cooccurring with the reconsolidation process has been less explored. Here we demonstrate that a memory retrieving event sets a neural tag, which enables the reconsolidation of memory after binding proteins provided by the original or a different contiguous experience. We characterized the specific temporal window during which this association is effective and identified the protein kinase A (PKA) and the extracellular signalregulated kinase 1 and 2 (ERK 1/2) pathways as the mechanisms related to the setting of the reconsolidation tag and the synthesis of proteins. Our results show, therefore, that memory reconsolidation is mediated by a “behavioral tagging” process, which is common to different memory forms. They represent a significant advance in understanding the fate of memories reconsolidated while being adjacent to other events, and provide a tool for designing noninvasive strategies to attenuate (pathological/traumatic) or improve (education-related) memories. " info:eu-repo/date/embargoEnd/2020-02-01 2020-10-28T15:50:27Z 2020-10-28T15:50:27Z 2020-07 Artículos de Publicaciones Periódicas info:eu-repo/semantics/acceptedVersion 0027-8424 http://ri.itba.edu.ar/handle/123456789/3217 en info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.2009517117 info:eu-repo/grantAgreement/ANPCyT/PICT/2015-2320/AR. Ciudad Autónoma de Buenos Aires info:eu-repo/semantics/embargoedAccess application/pdf
institution Instituto Tecnológico de Buenos Aires (ITBA)
institution_str I-32
repository_str R-138
collection Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA)
language Inglés
topic CONSOLIDACION DE LA MEMORIA
ETIQUETADO CONDUCTUAL
spellingShingle CONSOLIDACION DE LA MEMORIA
ETIQUETADO CONDUCTUAL
Rabinovich Orlandi, Iván
Fullio, Camila L.
Schroeder, Matías Nicolás
Giurfa, Martin
Ballarini, Fabricio
Moncada, Diego
Behavioral tagging underlies memory reconsolidation
topic_facet CONSOLIDACION DE LA MEMORIA
ETIQUETADO CONDUCTUAL
description "Memory reconsolidation occurs when a retrieving event destabilizes transiently a consolidated memory, triggering thereby a new process of restabilization that ensures memory persistence. Although this phenomenon has received wide attention, the effect of new information cooccurring with the reconsolidation process has been less explored. Here we demonstrate that a memory retrieving event sets a neural tag, which enables the reconsolidation of memory after binding proteins provided by the original or a different contiguous experience. We characterized the specific temporal window during which this association is effective and identified the protein kinase A (PKA) and the extracellular signalregulated kinase 1 and 2 (ERK 1/2) pathways as the mechanisms related to the setting of the reconsolidation tag and the synthesis of proteins. Our results show, therefore, that memory reconsolidation is mediated by a “behavioral tagging” process, which is common to different memory forms. They represent a significant advance in understanding the fate of memories reconsolidated while being adjacent to other events, and provide a tool for designing noninvasive strategies to attenuate (pathological/traumatic) or improve (education-related) memories. "
format Artículos de Publicaciones Periódicas
acceptedVersion
author Rabinovich Orlandi, Iván
Fullio, Camila L.
Schroeder, Matías Nicolás
Giurfa, Martin
Ballarini, Fabricio
Moncada, Diego
author_facet Rabinovich Orlandi, Iván
Fullio, Camila L.
Schroeder, Matías Nicolás
Giurfa, Martin
Ballarini, Fabricio
Moncada, Diego
author_sort Rabinovich Orlandi, Iván
title Behavioral tagging underlies memory reconsolidation
title_short Behavioral tagging underlies memory reconsolidation
title_full Behavioral tagging underlies memory reconsolidation
title_fullStr Behavioral tagging underlies memory reconsolidation
title_full_unstemmed Behavioral tagging underlies memory reconsolidation
title_sort behavioral tagging underlies memory reconsolidation
publishDate info
url http://ri.itba.edu.ar/handle/123456789/3217
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AT fulliocamilal behavioraltaggingunderliesmemoryreconsolidation
AT schroedermatiasnicolas behavioraltaggingunderliesmemoryreconsolidation
AT giurfamartin behavioraltaggingunderliesmemoryreconsolidation
AT ballarinifabricio behavioraltaggingunderliesmemoryreconsolidation
AT moncadadiego behavioraltaggingunderliesmemoryreconsolidation
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