Hemispheric-Specific Coupling Improves Modeling of Functional Connectivity Using Wilson–Cowan Dynamics

"Large-scale neural mass models have been widely used to simulate resting-state brain activity from structural connectivity. In this work, we extend a well-established Wilson--Cowan framework by introducing a novel hemispheric-specific coupling scheme that differentiates between intra-hemispher...

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Autores principales: Plüss, Ramiro, Villota, Hernán, Orio, Patricio
Formato: Preprint
Lenguaje:Inglés
Publicado: 2025
Materias:
MODELOS DE MASAS NEURONALES, ACOPLAMIENTO HEMISFÉRICO, CONECTIVIDAD FUNCIONAL, ASIMETRÍA CEREBRAL, NEUROCIENCIA COMPUTACIONAL, DINÁMICA CEREBRAL
Acceso en línea:https://hdl.handle.net/20.500.14769/5114
https://doi.org/10.48550/arXiv.2506.22951
Aporte de:
Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA) de Instituto Tecnológico de Buenos Aires (ITBA)
id I32-R138-20.500.14769-5114
record_format dspace
spelling I32-R138-20.500.14769-51142026-01-07T13:47:34Z Hemispheric-Specific Coupling Improves Modeling of Functional Connectivity Using Wilson–Cowan Dynamics Plüss, Ramiro Villota, Hernán Orio, Patricio MODELOS DE MASAS NEURONALES, ACOPLAMIENTO HEMISFÉRICO, CONECTIVIDAD FUNCIONAL, ASIMETRÍA CEREBRAL, NEUROCIENCIA COMPUTACIONAL, DINÁMICA CEREBRAL "Large-scale neural mass models have been widely used to simulate resting-state brain activity from structural connectivity. In this work, we extend a well-established Wilson--Cowan framework by introducing a novel hemispheric-specific coupling scheme that differentiates between intra-hemispheric and inter-hemispheric structural interactions. We apply this model to empirical cortical connectomes and resting-state fMRI data from matched control and schizophrenia groups. Simulated functional connectivity is computed from the band-limited envelope correlations of regional excitatory activity and compared against empirical functional connectivity matrices. Our results show that incorporating hemispheric asymmetries enhances the correlation between simulated and empirical functional connectivity, highlighting the importance of anatomically-informed coupling strategies in improving the biological realism of large-scale brain network models." 2025-10-13T19:23:26Z 2025-10-13T19:23:26Z 2025-09 Preprint https://hdl.handle.net/20.500.14769/5114 https://doi.org/10.48550/arXiv.2506.22951 en application/pdf
institution Instituto Tecnológico de Buenos Aires (ITBA)
institution_str I-32
repository_str R-138
collection Repositorio Institucional Instituto Tecnológico de Buenos Aires (ITBA)
language Inglés
topic MODELOS DE MASAS NEURONALES, ACOPLAMIENTO HEMISFÉRICO, CONECTIVIDAD FUNCIONAL, ASIMETRÍA CEREBRAL, NEUROCIENCIA COMPUTACIONAL, DINÁMICA CEREBRAL
spellingShingle MODELOS DE MASAS NEURONALES, ACOPLAMIENTO HEMISFÉRICO, CONECTIVIDAD FUNCIONAL, ASIMETRÍA CEREBRAL, NEUROCIENCIA COMPUTACIONAL, DINÁMICA CEREBRAL
Plüss, Ramiro
Villota, Hernán
Orio, Patricio
Hemispheric-Specific Coupling Improves Modeling of Functional Connectivity Using Wilson–Cowan Dynamics
topic_facet MODELOS DE MASAS NEURONALES, ACOPLAMIENTO HEMISFÉRICO, CONECTIVIDAD FUNCIONAL, ASIMETRÍA CEREBRAL, NEUROCIENCIA COMPUTACIONAL, DINÁMICA CEREBRAL
description "Large-scale neural mass models have been widely used to simulate resting-state brain activity from structural connectivity. In this work, we extend a well-established Wilson--Cowan framework by introducing a novel hemispheric-specific coupling scheme that differentiates between intra-hemispheric and inter-hemispheric structural interactions. We apply this model to empirical cortical connectomes and resting-state fMRI data from matched control and schizophrenia groups. Simulated functional connectivity is computed from the band-limited envelope correlations of regional excitatory activity and compared against empirical functional connectivity matrices. Our results show that incorporating hemispheric asymmetries enhances the correlation between simulated and empirical functional connectivity, highlighting the importance of anatomically-informed coupling strategies in improving the biological realism of large-scale brain network models."
format Preprint
author Plüss, Ramiro
Villota, Hernán
Orio, Patricio
author_facet Plüss, Ramiro
Villota, Hernán
Orio, Patricio
author_sort Plüss, Ramiro
title Hemispheric-Specific Coupling Improves Modeling of Functional Connectivity Using Wilson–Cowan Dynamics
title_short Hemispheric-Specific Coupling Improves Modeling of Functional Connectivity Using Wilson–Cowan Dynamics
title_full Hemispheric-Specific Coupling Improves Modeling of Functional Connectivity Using Wilson–Cowan Dynamics
title_fullStr Hemispheric-Specific Coupling Improves Modeling of Functional Connectivity Using Wilson–Cowan Dynamics
title_full_unstemmed Hemispheric-Specific Coupling Improves Modeling of Functional Connectivity Using Wilson–Cowan Dynamics
title_sort hemispheric-specific coupling improves modeling of functional connectivity using wilson–cowan dynamics
publishDate 2025
url https://hdl.handle.net/20.500.14769/5114
https://doi.org/10.48550/arXiv.2506.22951
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AT villotahernan hemisphericspecificcouplingimprovesmodelingoffunctionalconnectivityusingwilsoncowandynamics
AT oriopatricio hemisphericspecificcouplingimprovesmodelingoffunctionalconnectivityusingwilsoncowandynamics
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