The unfolding palette of COVID-19 multisystemic syndrome and its neurological manifestations

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Abstract: Although our current knowledge of the pathophysiology of COVID-19 is still fragmentary, the information so far accrued on the tropism and life cycle of its etiological agent SARS-CoV-2, together with the emerging clinical data, suffice to indicate that the severe acute pulmonary syndrome...

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Autor principal: Barrantes, Francisco José
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier 2021
Materias:
COVID-19
SISTEMA NERVIOSO CENTRAL
SARS-CoV-2
CEREBRO
INFECCIONES
VIRUS
NEUROTROPISMO
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/12527
https://doi.org/10.1016/j.bbih.2021.100251
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-12527
record_format dspace
spelling I33-R139-123456789-125272023-11-22T21:59:49Z The unfolding palette of COVID-19 multisystemic syndrome and its neurological manifestations Barrantes, Francisco José COVID-19 SISTEMA NERVIOSO CENTRAL SARS-CoV-2 CEREBRO INFECCIONES VIRUS NEUROTROPISMO Abstract: Although our current knowledge of the pathophysiology of COVID-19 is still fragmentary, the information so far accrued on the tropism and life cycle of its etiological agent SARS-CoV-2, together with the emerging clinical data, suffice to indicate that the severe acute pulmonary syndrome is the main, but not the only manifestation of COVID-19. Necropsy studies are increasingly revealing underlying endothelial vasculopathies in the form of micro-haemorrhages and micro-thrombi. Intertwined with defective antiviral responses, dysregulated coagulation mechanisms, abnormal hyper-inflammatory reactions and responses, COVID-19 is disclosing a wide pathophysiological palette. An additional property in categorising the disease is the combination of tissue (e.g. neuro- and vasculo-tropism) with organ tropism, whereby the virus preferentially attacks certain organs with highly developed capillary beds, such as the lungs, gastrointestinal tract, kidney and brain. These multiple clinical presentations confirm that the acute respiratory syndrome as described initially is increasingly unfolding as a more complex nosological entity, a multiorgan syndrome of systemic breadth. The neurological manifestations of COVID-19, the focus of this review, reflect this manifold nature of the disease. 2021-10-25T12:57:17Z 2021-10-25T12:57:17Z 2021 Artículo Barrantes, F. J. The unfolding palette of COVID-19 multisystemic syndrome and its neurological manifestations [en línea]. Brain, Behavior, & Immunity - Health. 2021, 14 (100251). doi: https://doi.org/10.1016/j.bbih.2021.100251. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/12527 2666-3546 (online) https://repositorio.uca.edu.ar/handle/123456789/12527 https://doi.org/10.1016/j.bbih.2021.100251 33842898 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Elsevier Brain, Behavior, & Immunity - Health Vol.14, 100251, 2021
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic COVID-19
SISTEMA NERVIOSO CENTRAL
SARS-CoV-2
CEREBRO
INFECCIONES
VIRUS
NEUROTROPISMO
spellingShingle COVID-19
SISTEMA NERVIOSO CENTRAL
SARS-CoV-2
CEREBRO
INFECCIONES
VIRUS
NEUROTROPISMO
Barrantes, Francisco José
The unfolding palette of COVID-19 multisystemic syndrome and its neurological manifestations
topic_facet COVID-19
SISTEMA NERVIOSO CENTRAL
SARS-CoV-2
CEREBRO
INFECCIONES
VIRUS
NEUROTROPISMO
description Abstract: Although our current knowledge of the pathophysiology of COVID-19 is still fragmentary, the information so far accrued on the tropism and life cycle of its etiological agent SARS-CoV-2, together with the emerging clinical data, suffice to indicate that the severe acute pulmonary syndrome is the main, but not the only manifestation of COVID-19. Necropsy studies are increasingly revealing underlying endothelial vasculopathies in the form of micro-haemorrhages and micro-thrombi. Intertwined with defective antiviral responses, dysregulated coagulation mechanisms, abnormal hyper-inflammatory reactions and responses, COVID-19 is disclosing a wide pathophysiological palette. An additional property in categorising the disease is the combination of tissue (e.g. neuro- and vasculo-tropism) with organ tropism, whereby the virus preferentially attacks certain organs with highly developed capillary beds, such as the lungs, gastrointestinal tract, kidney and brain. These multiple clinical presentations confirm that the acute respiratory syndrome as described initially is increasingly unfolding as a more complex nosological entity, a multiorgan syndrome of systemic breadth. The neurological manifestations of COVID-19, the focus of this review, reflect this manifold nature of the disease.
format Artículo
author Barrantes, Francisco José
author_facet Barrantes, Francisco José
author_sort Barrantes, Francisco José
title The unfolding palette of COVID-19 multisystemic syndrome and its neurological manifestations
title_short The unfolding palette of COVID-19 multisystemic syndrome and its neurological manifestations
title_full The unfolding palette of COVID-19 multisystemic syndrome and its neurological manifestations
title_fullStr The unfolding palette of COVID-19 multisystemic syndrome and its neurological manifestations
title_full_unstemmed The unfolding palette of COVID-19 multisystemic syndrome and its neurological manifestations
title_sort unfolding palette of covid-19 multisystemic syndrome and its neurological manifestations
publisher Elsevier
publishDate 2021
url https://repositorio.uca.edu.ar/handle/123456789/12527
https://doi.org/10.1016/j.bbih.2021.100251
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