From hopanoids to cholesterol : molecular clocks of pentameric ligand-gated ion channels

Abstract: Pentameric ligand-gated ion channels (pLGICs) and their lipid microenvironments appear to have acquired mutually adaptive traits along evolution: 1) the three-ring architecture of their transmembrane (TM) region; 2) the ability of the outermost TM ring to convey lipid signals to the middle...

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Detalles Bibliográficos
Autores principales: Barrantes, Francisco José, Fantini, Jacques
Formato: Artículo
Lenguaje:Español
Publicado: Elsevier 2022
Materias:
COLESTEROL
CANALES IONICOS
HOPANOIDES
ESTEROIDES
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14049
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14049
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Español
topic COLESTEROL
CANALES IONICOS
HOPANOIDES
ESTEROIDES
spellingShingle COLESTEROL
CANALES IONICOS
HOPANOIDES
ESTEROIDES
Barrantes, Francisco José
Fantini, Jacques
From hopanoids to cholesterol : molecular clocks of pentameric ligand-gated ion channels
topic_facet COLESTEROL
CANALES IONICOS
HOPANOIDES
ESTEROIDES
description Abstract: Pentameric ligand-gated ion channels (pLGICs) and their lipid microenvironments appear to have acquired mutually adaptive traits along evolution: 1) the three-ring architecture of their transmembrane (TM) region; 2) the ability of the outermost TM ring to convey lipid signals to the middle ring, which passes them on to the central pore ring, and 3) consensus motifs for sterol recognition in all pLGICs. Hopanoids are triterpenoid fossil lipids that constitute invaluable biomarkers for tracing evolution at the molecular scale. The cyanobacterium Gloeobacter violaceus is the oldest known living organism in which the X-ray structure of its pLGIC, GLIC, reveals the presence of the above attributes and, as discussed in this review, the ability to bind hopanoids. ELIC, the pLGIC from the bacillus Erwinia chrysanthemi is the only other known case to date. Both prokaryotes lack cholesterol but their pLGICs exhibit the same sterol motifs as mammalian pLGIC. This remarkable conservation suggests that the association of sterols and hopanoid surrogate molecules arose from the early need in prokaryotes to stabilize pLGIC TM regions by means of relatively rigid lipid molecules. The conservation of these phenotypic traits along such a long phylogenetic span leads us to suggest the possible co-evolution of these sterols with pLGICs.
format Artículo
author Barrantes, Francisco José
Fantini, Jacques
author_facet Barrantes, Francisco José
Fantini, Jacques
author_sort Barrantes, Francisco José
title From hopanoids to cholesterol : molecular clocks of pentameric ligand-gated ion channels
title_short From hopanoids to cholesterol : molecular clocks of pentameric ligand-gated ion channels
title_full From hopanoids to cholesterol : molecular clocks of pentameric ligand-gated ion channels
title_fullStr From hopanoids to cholesterol : molecular clocks of pentameric ligand-gated ion channels
title_full_unstemmed From hopanoids to cholesterol : molecular clocks of pentameric ligand-gated ion channels
title_sort from hopanoids to cholesterol : molecular clocks of pentameric ligand-gated ion channels
publisher Elsevier
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14049
work_keys_str_mv AT barrantesfranciscojose fromhopanoidstocholesterolmolecularclocksofpentamericligandgatedionchannels
AT fantinijacques fromhopanoidstocholesterolmolecularclocksofpentamericligandgatedionchannels
bdutipo_str Repositorios
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