Impact of histamine H4 receptor deficiency on the modulation of T cells in a murine breast cancer model

Abstract: Background: The histamine H4 receptor (H4R) is preferentially expressed in immune cells and is a potential therapeutic target for inflammatory and autoimmune diseases. This study aimed at further exploring the role of H4R in the immunobiology of breast cancer. Methods: We used wild type...

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Autores principales: Nicoud, Melisa Beatriz, Táquez Delgado, Mónica Alejandra, Sarasola, María de la Paz, Vidal, María Agustina, Speisky, Daniela, Cremaschi, Graciela A., Sterle, Helena Andrea, Medina, Vanina Araceli
Formato: Artículo
Lenguaje:Inglés
Publicado: Springer 2022
Materias:
INMUNIDAD ANTITUMORAL
CANCER DE MAMA
HISTAMINA
CELULAS T
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/14233
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-14233
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic INMUNIDAD ANTITUMORAL
CANCER DE MAMA
HISTAMINA
CELULAS T
spellingShingle INMUNIDAD ANTITUMORAL
CANCER DE MAMA
HISTAMINA
CELULAS T
Nicoud, Melisa Beatriz
Táquez Delgado, Mónica Alejandra
Sarasola, María de la Paz
Vidal, María Agustina
Speisky, Daniela
Cremaschi, Graciela A.
Sterle, Helena Andrea
Medina, Vanina Araceli
Impact of histamine H4 receptor deficiency on the modulation of T cells in a murine breast cancer model
topic_facet INMUNIDAD ANTITUMORAL
CANCER DE MAMA
HISTAMINA
CELULAS T
description Abstract: Background: The histamine H4 receptor (H4R) is preferentially expressed in immune cells and is a potential therapeutic target for inflammatory and autoimmune diseases. This study aimed at further exploring the role of H4R in the immunobiology of breast cancer. Methods: We used wild type (WT) and H4R deficient mice (KO) to evaluate whether H4R genotypes show a different distribution of T cell subsets in spleens, tumours and tumour draining lymph nodes (TDLN) in a syngeneic ErbB2-positive breast cancer model developed orthotopically with LM3 cells and its impact on tumour growth. Results: The presence of tumours had a differential impact on the distribution of T cells in TDLN from KO mice compared to WT ones. At day 21 post-inoculation (p.i.) of cells, despite no significant changes in the tumour weight, TDLN from KO mice showed a significantly increased proportion of CD8+ T cells compared to WT mice. At day 38 p.i. of cells a reduced tumour weight was evident in KO mice. This was accompanied by a decreased proportion of CD4+CD25+FoxP3+ regulatory T cells in TDLN of KO compared to WT mice. Tumour-bearing KO mice showed a better survival compared to WT mice. Conclusions: H4R-mediated mechanisms may modulate the immune tumour microenvironment, promoting an immunosuppressive milieu. Results suggest that H4R could be explored as an immunotherapeutic target with potential benefit in combination with immunotherapy. Further preclinical and clinical studies are necessary to confirm this hypothesis.
format Artículo
author Nicoud, Melisa Beatriz
Táquez Delgado, Mónica Alejandra
Sarasola, María de la Paz
Vidal, María Agustina
Speisky, Daniela
Cremaschi, Graciela A.
Sterle, Helena Andrea
Medina, Vanina Araceli
author_facet Nicoud, Melisa Beatriz
Táquez Delgado, Mónica Alejandra
Sarasola, María de la Paz
Vidal, María Agustina
Speisky, Daniela
Cremaschi, Graciela A.
Sterle, Helena Andrea
Medina, Vanina Araceli
author_sort Nicoud, Melisa Beatriz
title Impact of histamine H4 receptor deficiency on the modulation of T cells in a murine breast cancer model
title_short Impact of histamine H4 receptor deficiency on the modulation of T cells in a murine breast cancer model
title_full Impact of histamine H4 receptor deficiency on the modulation of T cells in a murine breast cancer model
title_fullStr Impact of histamine H4 receptor deficiency on the modulation of T cells in a murine breast cancer model
title_full_unstemmed Impact of histamine H4 receptor deficiency on the modulation of T cells in a murine breast cancer model
title_sort impact of histamine h4 receptor deficiency on the modulation of t cells in a murine breast cancer model
publisher Springer
publishDate 2022
url https://repositorio.uca.edu.ar/handle/123456789/14233
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