Sexual dimorphism modulates metabolic and cognitive alterations under HFD nutrition and chronic stress exposure in mice : correlation between spatial memory impairment and BDNF mRNA expression in hippocampus and spleen
Abstract: Aims: The accumulated evidence suggests that lifestyle - specifically dietary habits and stress exposure - plays a detrimental role in health. The purpose of the present study was to analyze the interplay of stress, diet, and sex in metabolic and cognitive alterations. Main methods: For...
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| Formato: | Artículo |
| Lenguaje: | Inglés |
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Elsevier
2022
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| Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/15451 |
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I33-R139-123456789-154512023-11-23T17:39:34Z Sexual dimorphism modulates metabolic and cognitive alterations under HFD nutrition and chronic stress exposure in mice : correlation between spatial memory impairment and BDNF mRNA expression in hippocampus and spleen Prochnika, Andrés Burgueño, Adriana Laura Rubinstein Guichón, Mara Roxana Marcone, María Paula Bianchi, María S. González Murano, María Rosa Genaro, Ana María Wald, Miriam Ruth HABITOS ALIMENTARIOS DIETA RICA EN GRASAS STRESS SEXO COGNICION METABOLISMO NEUROTROFINAS LINFOCITOS PERIFÉRICOS Abstract: Aims: The accumulated evidence suggests that lifestyle - specifically dietary habits and stress exposure - plays a detrimental role in health. The purpose of the present study was to analyze the interplay of stress, diet, and sex in metabolic and cognitive alterations. Main methods: For this purpose, one-month-old C57Bl/6J mice were fed with a standard diet or high-fat diet (HFD). After eight weeks, one subgroup of mice from each respective diet was exposed to 20 weeks of chronic mild stress (CMS), whilst the others were left undisturbed. Key findings: After 28 weeks of HFD feeding, mice from both sexes were overweight, with an increase in caloric intake and abdominal and subcutaneous fat pads. Stress exposure induced a decrease in body weight, related to a decrease in caloric efficiency in both males and females. Results indicate that males are more susceptible than the females in modulating metabolic and cognitive functions under HFD and CMS. Although both sexes demonstrated HFD-induced weight gain, fat accumulation, insulin resistance, high cholesterol, only males exposed to CMS but not females have (i) impaired glucose tolerance with higher glucose level; (ii) significant prolonged latency in Barnes test, suggesting cognitive impairment; (iii) increased IFN-gamma expression in hippocampus, suggesting greater neuroinflammatory response; (iv) poorer cognitive performance related to a decrease in hippocampal and spleen BDNF mRNA expression. Significance: The main finding in this study is the presence of a sexual dimorphism in modulating metabolic and cognitive functions under HFD and CMS, showing males are more susceptible than females. In addition, poorer cognitive performance was related to a decrease in hippocampal BDNF mRNA expression. Interestingly, these changes were observed in the spleen as well. 2022-11-11T10:46:22Z 2022-11-11T10:46:28Z 2022-11-11T10:46:22Z 2022-11-11T10:46:28Z 2022 Artículo Genaro, A. M. et al. Sexual dimorphism modulates metabolic and cognitive alterations under HFD nutrition and chronic stress exposure in mice : correlation between spatial memory impairment and BDNF mRNA expression in hippocampus and spleen [en línea]. Postprint de artículo publicado en: Neurochemistry International. 2022, 160. doi: 10.1016/j.neuint.2022.105416. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/15451 0197-0186 (impreso) 1872-9754 (online) https://repositorio.uca.edu.ar/handle/123456789/15451 10.1016/j.neuint.2022.105416 36055604 eng Interrelación obesidad-estrés en la génesis de trastornos cognitivos. Papel de la inmunidad innata y la flora bacteriana Acceso restringido http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Elsevier Postprint de artículo publicado en: Neurochemistry International. 2022, 160 |
| institution |
Universidad Católica Argentina |
| institution_str |
I-33 |
| repository_str |
R-139 |
| collection |
Repositorio Institucional de la Universidad Católica Argentina (UCA) |
| language |
Inglés |
| topic |
HABITOS ALIMENTARIOS DIETA RICA EN GRASAS STRESS SEXO COGNICION METABOLISMO NEUROTROFINAS LINFOCITOS PERIFÉRICOS |
| spellingShingle |
HABITOS ALIMENTARIOS DIETA RICA EN GRASAS STRESS SEXO COGNICION METABOLISMO NEUROTROFINAS LINFOCITOS PERIFÉRICOS Prochnika, Andrés Burgueño, Adriana Laura Rubinstein Guichón, Mara Roxana Marcone, María Paula Bianchi, María S. González Murano, María Rosa Genaro, Ana María Wald, Miriam Ruth Sexual dimorphism modulates metabolic and cognitive alterations under HFD nutrition and chronic stress exposure in mice : correlation between spatial memory impairment and BDNF mRNA expression in hippocampus and spleen |
| topic_facet |
HABITOS ALIMENTARIOS DIETA RICA EN GRASAS STRESS SEXO COGNICION METABOLISMO NEUROTROFINAS LINFOCITOS PERIFÉRICOS |
| description |
Abstract: Aims: The accumulated evidence suggests that lifestyle - specifically dietary habits and
stress exposure - plays a detrimental role in health. The purpose of the present study was
to analyze the interplay of stress, diet, and sex in metabolic and cognitive alterations.
Main methods: For this purpose, one-month-old C57Bl/6J mice were fed with a standard
diet or high-fat diet (HFD). After eight weeks, one subgroup of mice from each respective
diet was exposed to 20 weeks of chronic mild stress (CMS), whilst the others were left
undisturbed.
Key findings: After 28 weeks of HFD feeding, mice from both sexes were overweight, with
an increase in caloric intake and abdominal and subcutaneous fat pads. Stress exposure
induced a decrease in body weight, related to a decrease in caloric efficiency in both
males and females. Results indicate that males are more susceptible than the females in
modulating metabolic and cognitive functions under HFD and CMS. Although both sexes
demonstrated HFD-induced weight gain, fat accumulation, insulin resistance, high
cholesterol, only males exposed to CMS but not females have (i) impaired glucose
tolerance with higher glucose level; (ii) significant prolonged latency in Barnes test,
suggesting cognitive impairment; (iii) increased IFN-gamma expression in hippocampus,
suggesting greater neuroinflammatory response; (iv) poorer cognitive performance related
to a decrease in hippocampal and spleen BDNF mRNA expression.
Significance: The main finding in this study is the presence of a sexual dimorphism in
modulating metabolic and cognitive functions under HFD and CMS, showing males are
more susceptible than females. In addition, poorer cognitive performance was related to a
decrease in hippocampal BDNF mRNA expression. Interestingly, these changes were
observed in the spleen as well. |
| format |
Artículo |
| author |
Prochnika, Andrés Burgueño, Adriana Laura Rubinstein Guichón, Mara Roxana Marcone, María Paula Bianchi, María S. González Murano, María Rosa Genaro, Ana María Wald, Miriam Ruth |
| author_facet |
Prochnika, Andrés Burgueño, Adriana Laura Rubinstein Guichón, Mara Roxana Marcone, María Paula Bianchi, María S. González Murano, María Rosa Genaro, Ana María Wald, Miriam Ruth |
| author_sort |
Prochnika, Andrés |
| title |
Sexual dimorphism modulates metabolic and cognitive alterations under HFD nutrition and chronic stress exposure in mice : correlation between spatial memory impairment and BDNF mRNA expression in hippocampus and spleen |
| title_short |
Sexual dimorphism modulates metabolic and cognitive alterations under HFD nutrition and chronic stress exposure in mice : correlation between spatial memory impairment and BDNF mRNA expression in hippocampus and spleen |
| title_full |
Sexual dimorphism modulates metabolic and cognitive alterations under HFD nutrition and chronic stress exposure in mice : correlation between spatial memory impairment and BDNF mRNA expression in hippocampus and spleen |
| title_fullStr |
Sexual dimorphism modulates metabolic and cognitive alterations under HFD nutrition and chronic stress exposure in mice : correlation between spatial memory impairment and BDNF mRNA expression in hippocampus and spleen |
| title_full_unstemmed |
Sexual dimorphism modulates metabolic and cognitive alterations under HFD nutrition and chronic stress exposure in mice : correlation between spatial memory impairment and BDNF mRNA expression in hippocampus and spleen |
| title_sort |
sexual dimorphism modulates metabolic and cognitive alterations under hfd nutrition and chronic stress exposure in mice : correlation between spatial memory impairment and bdnf mrna expression in hippocampus and spleen |
| publisher |
Elsevier |
| publishDate |
2022 |
| url |
https://repositorio.uca.edu.ar/handle/123456789/15451 |
| work_keys_str_mv |
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| _version_ |
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