Early life stress and its impact on physiological fitness

Abstract: Our physiology is modified by the environment during critical periods of development from gestational to infancy, even in some cases during adolescence. Stressful experiences are often a challenge to physiological homeostasis. Thus, when exposure to stressful experiences occurs during c...

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Autores principales: Burgueño, Adriana Laura, Astiz, Mariana, Dagnino Subiabre, Alexies
Otros Autores: 0000-0002-9909-9826
Formato: Artículo
Lenguaje:Inglés
Publicado: Frontiers Media 2023
Materias:
STRESS
DESARROLLO DEL NIÑO
DESARROLLO CEREBRAL
FISIOLOGIA
METABOLISMO
GENETICA
APTITUD FISICA
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/16408
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-16408
record_format dspace
spelling I33-R139-123456789-164082023-11-23T17:44:22Z Early life stress and its impact on physiological fitness Burgueño, Adriana Laura Astiz, Mariana Dagnino Subiabre, Alexies 0000-0002-9909-9826 STRESS DESARROLLO DEL NIÑO DESARROLLO CEREBRAL FISIOLOGIA METABOLISMO GENETICA APTITUD FISICA Abstract: Our physiology is modified by the environment during critical periods of development from gestational to infancy, even in some cases during adolescence. Stressful experiences are often a challenge to physiological homeostasis. Thus, when exposure to stressful experiences occurs during critical periods such as embryonic development or early life, these experiences have a “programming” effect on the health, changing the developmental trajectory and generating long-lasting changes in the structure and/or function of different organs and systems (Zambrano et al., 2016). Early life stress leads to physiological alterations, from metabolism to behavior evidenced by several studies in humans and animals. The effect of maternal starvation from preconception to early childhood, such as in the Dutch famine of World War II, or exposure to stressful events in the Holocaust, has shown associations between early stress and later obesity, and metabolic and behavioral disorders (Painter et al., 2006; Roseboom et al., 2006; Flory et al., 2011). Research on stress has focused on understanding the mechanism of the stress response as well as the specific effects of stress on individuals, using several animal models (Jaggi et al., 2011). Several of these studies have shown important features, one is that the effects of early life stress are also affecting subsequent generations through epigenetic inheritance. Epidemiological, experimental and literature review studies as those included in this collection are essential to understand the impact of the early environment on the wide spectrum of systems that end up ruling physiological fitness. Maternal care is clearly one relevant stress factor. In this Research Topic, Dumas reviews the history of maternal care research, highlighting the importance of this key social interaction shaping adult mental and physical health. Ding et al. conducted a brain imaging study on left-behind children in China. They demonstrated that left-behind children, in addition to deficits in their social-emotional skills, show a decrease in synchronization strength and asymmetry in the right middle frontal gyrus during joint attention. The authors suggested that those might be vulnerability factors in the development of leftbehind children. In line with this, Leon el al. provides the first evidence of mother-child epigenetic mark of neglectful caregiving. Nine differentially methylated regions (DMR) were found in common among mothers with neglectful and neglected children, some DMRs contained genes related to childhood adversity, neonatal and infant diabetes, obesity, hypertension, posttraumatic stress, and cancer. 2023-05-29T09:55:15Z 2023-05-29T09:55:15Z 2022 Artículo Burgueño, A. L., Astiz, M., Dagnino Subiabre, A. Early life stress and its impact on physiological fitness [en línea]. Frontiers in Physiology. 2022, 13:1037409. doi: 10.3389/fphys.2022.1037409. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16408 1664-042X (online) https://repositorio.uca.edu.ar/handle/123456789/16408 10.3389/fphys.2022.1037409 36311251 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Frontiers Media Frontiers in Physiology. 2022, 13:1037409
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic STRESS
DESARROLLO DEL NIÑO
DESARROLLO CEREBRAL
FISIOLOGIA
METABOLISMO
GENETICA
APTITUD FISICA
spellingShingle STRESS
DESARROLLO DEL NIÑO
DESARROLLO CEREBRAL
FISIOLOGIA
METABOLISMO
GENETICA
APTITUD FISICA
Burgueño, Adriana Laura
Astiz, Mariana
Dagnino Subiabre, Alexies
Early life stress and its impact on physiological fitness
topic_facet STRESS
DESARROLLO DEL NIÑO
DESARROLLO CEREBRAL
FISIOLOGIA
METABOLISMO
GENETICA
APTITUD FISICA
description Abstract: Our physiology is modified by the environment during critical periods of development from gestational to infancy, even in some cases during adolescence. Stressful experiences are often a challenge to physiological homeostasis. Thus, when exposure to stressful experiences occurs during critical periods such as embryonic development or early life, these experiences have a “programming” effect on the health, changing the developmental trajectory and generating long-lasting changes in the structure and/or function of different organs and systems (Zambrano et al., 2016). Early life stress leads to physiological alterations, from metabolism to behavior evidenced by several studies in humans and animals. The effect of maternal starvation from preconception to early childhood, such as in the Dutch famine of World War II, or exposure to stressful events in the Holocaust, has shown associations between early stress and later obesity, and metabolic and behavioral disorders (Painter et al., 2006; Roseboom et al., 2006; Flory et al., 2011). Research on stress has focused on understanding the mechanism of the stress response as well as the specific effects of stress on individuals, using several animal models (Jaggi et al., 2011). Several of these studies have shown important features, one is that the effects of early life stress are also affecting subsequent generations through epigenetic inheritance. Epidemiological, experimental and literature review studies as those included in this collection are essential to understand the impact of the early environment on the wide spectrum of systems that end up ruling physiological fitness. Maternal care is clearly one relevant stress factor. In this Research Topic, Dumas reviews the history of maternal care research, highlighting the importance of this key social interaction shaping adult mental and physical health. Ding et al. conducted a brain imaging study on left-behind children in China. They demonstrated that left-behind children, in addition to deficits in their social-emotional skills, show a decrease in synchronization strength and asymmetry in the right middle frontal gyrus during joint attention. The authors suggested that those might be vulnerability factors in the development of leftbehind children. In line with this, Leon el al. provides the first evidence of mother-child epigenetic mark of neglectful caregiving. Nine differentially methylated regions (DMR) were found in common among mothers with neglectful and neglected children, some DMRs contained genes related to childhood adversity, neonatal and infant diabetes, obesity, hypertension, posttraumatic stress, and cancer.
author2 0000-0002-9909-9826
author_facet 0000-0002-9909-9826
Burgueño, Adriana Laura
Astiz, Mariana
Dagnino Subiabre, Alexies
format Artículo
author Burgueño, Adriana Laura
Astiz, Mariana
Dagnino Subiabre, Alexies
author_sort Burgueño, Adriana Laura
title Early life stress and its impact on physiological fitness
title_short Early life stress and its impact on physiological fitness
title_full Early life stress and its impact on physiological fitness
title_fullStr Early life stress and its impact on physiological fitness
title_full_unstemmed Early life stress and its impact on physiological fitness
title_sort early life stress and its impact on physiological fitness
publisher Frontiers Media
publishDate 2023
url https://repositorio.uca.edu.ar/handle/123456789/16408
work_keys_str_mv AT burguenoadrianalaura earlylifestressanditsimpactonphysiologicalfitness
AT astizmariana earlylifestressanditsimpactonphysiologicalfitness
AT dagninosubiabrealexies earlylifestressanditsimpactonphysiologicalfitness
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