Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure

Abstract: Abstract: The term ‘perinatal environment’ refers to the period surrounding birth, which plays a crucial role in brain development. It has been suggested that dynamic communication between the neuro–immune system and gut microbiota is essential in maintaining adequate brain function. Thi...

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Autores principales: Rubinstein Guichón, Mara Roxana, Burgueño, Adriana Laura, Quiroga, Sofia, Wald, Miriam Ruth, Genaro, Ana María
Formato: Artículo
Lenguaje:Inglés
Publicado: MDPI 2023
Materias:
STRESS PRENATAL
DEFICIT COGNITIVO
INTESTINOS
MELATONINA
CEREBRO
ENRIQUECIMIENTO AMBIENTAL
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/17342
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139-123456789-17342
record_format dspace
spelling I33-R139-123456789-173422023-11-23T18:01:24Z Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure Rubinstein Guichón, Mara Roxana Burgueño, Adriana Laura Quiroga, Sofia Wald, Miriam Ruth Genaro, Ana María STRESS PRENATAL DEFICIT COGNITIVO INTESTINOS MELATONINA CEREBRO ENRIQUECIMIENTO AMBIENTAL Abstract: Abstract: The term ‘perinatal environment’ refers to the period surrounding birth, which plays a crucial role in brain development. It has been suggested that dynamic communication between the neuro–immune system and gut microbiota is essential in maintaining adequate brain function. This interaction depends on the mother’s status during pregnancy and/or the newborn environment. Here, we show experimental and clinical evidence that indicates that the perinatal period is a critical window in which stress-induced immune activation and altered microbiota compositions produce lasting behavioral consequences, although a clear causative relationship has not yet been established. In addition, we discuss potential early treatments for preventing the deleterious effect of perinatal stress exposure. In this sense, early environmental enrichment exposure (including exercise) and melatonin use in the perinatal period could be valuable in improving the negative consequences of early adversities. The evidence presented in this review encourages the realization of studies investigating the beneficial role of melatonin administration and environmental enrichment exposure in mitigating cognitive alteration in offspring under perinatal stress exposure. On the other hand, direct evidence of microbiota restoration as the main mechanism behind the beneficial effects of this treatment has not been fully demonstrated and should be explored in future studies. 2023-10-24T07:28:37Z 2023-10-24T07:28:37Z 2023 Artículo Rubinstein, M.R., Burgueño, A.L., Quiroga, S., Wald, M.R., Genaro, A.M. Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure [en línea]. Cells. 2023, 12, 1735. doi: 10.3390/cells12131735. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/17342 2073-4409 https://repositorio.uca.edu.ar/handle/123456789/17342 10.3390/cells12131735 37443769 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf MDPI Cells. 2023, 12, 1735
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic STRESS PRENATAL
DEFICIT COGNITIVO
INTESTINOS
MELATONINA
CEREBRO
ENRIQUECIMIENTO AMBIENTAL
spellingShingle STRESS PRENATAL
DEFICIT COGNITIVO
INTESTINOS
MELATONINA
CEREBRO
ENRIQUECIMIENTO AMBIENTAL
Rubinstein Guichón, Mara Roxana
Burgueño, Adriana Laura
Quiroga, Sofia
Wald, Miriam Ruth
Genaro, Ana María
Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure
topic_facet STRESS PRENATAL
DEFICIT COGNITIVO
INTESTINOS
MELATONINA
CEREBRO
ENRIQUECIMIENTO AMBIENTAL
description Abstract: Abstract: The term ‘perinatal environment’ refers to the period surrounding birth, which plays a crucial role in brain development. It has been suggested that dynamic communication between the neuro–immune system and gut microbiota is essential in maintaining adequate brain function. This interaction depends on the mother’s status during pregnancy and/or the newborn environment. Here, we show experimental and clinical evidence that indicates that the perinatal period is a critical window in which stress-induced immune activation and altered microbiota compositions produce lasting behavioral consequences, although a clear causative relationship has not yet been established. In addition, we discuss potential early treatments for preventing the deleterious effect of perinatal stress exposure. In this sense, early environmental enrichment exposure (including exercise) and melatonin use in the perinatal period could be valuable in improving the negative consequences of early adversities. The evidence presented in this review encourages the realization of studies investigating the beneficial role of melatonin administration and environmental enrichment exposure in mitigating cognitive alteration in offspring under perinatal stress exposure. On the other hand, direct evidence of microbiota restoration as the main mechanism behind the beneficial effects of this treatment has not been fully demonstrated and should be explored in future studies.
format Artículo
author Rubinstein Guichón, Mara Roxana
Burgueño, Adriana Laura
Quiroga, Sofia
Wald, Miriam Ruth
Genaro, Ana María
author_facet Rubinstein Guichón, Mara Roxana
Burgueño, Adriana Laura
Quiroga, Sofia
Wald, Miriam Ruth
Genaro, Ana María
author_sort Rubinstein Guichón, Mara Roxana
title Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure
title_short Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure
title_full Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure
title_fullStr Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure
title_full_unstemmed Current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure
title_sort current understanding of the roles of gut–brain axis in the cognitive deficits caused by perinatal stress exposure
publisher MDPI
publishDate 2023
url https://repositorio.uca.edu.ar/handle/123456789/17342
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