Risk of myocarditis and pericarditis in mRNA COVID-19-vaccinated and unvaccinated populations: a systematic review and meta-analysis
Abstract: Objective To summarise the available evidence on the risk of myocarditis and/or pericarditis following mRNA COVID-19 vaccination, compared with the risk among unvaccinated individuals in the absence of COVID-19 infection. Design Systematic review and meta-analysis. Data sources Elect...
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BMJ Publishing Group
2023
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| Acceso en línea: | https://repositorio.uca.edu.ar/handle/123456789/17346 |
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I33-R139-123456789-173462024-03-21T19:25:46Z Risk of myocarditis and pericarditis in mRNA COVID-19-vaccinated and unvaccinated populations: a systematic review and meta-analysis Alami, Abdallah Krewski, Daniel Farhat, Nawal Mattison, Donald Wilson, Kumanan Gravel, Christopher A. Farrell, Patrick J. Crispo, James A. G. Pérez Lloret, Santiago Villeneuve, Paul J. Haddad, Nisrine COVID-19 EPIDEMIOLOGIA SALUD PUBLICA. MIOCARDITIS PERICARDITIS Abstract: Objective To summarise the available evidence on the risk of myocarditis and/or pericarditis following mRNA COVID-19 vaccination, compared with the risk among unvaccinated individuals in the absence of COVID-19 infection. Design Systematic review and meta-analysis. Data sources Electronic databases (Medline, Embase, Web of Science and WHO Global Literature on Coronavirus Disease), preprint repositories (medRxiv and bioRxiv), reference lists and grey literature were searched from 1 December 2020 until 31 October 2022. Study selection Epidemiological studies of individuals of any age who received at least one dose of an mRNA COVID-19 vaccine, reported a risk of myo/pericarditis and compared the risk of myo/pericarditis to individuals who did not receive any dose of an mRNA COVID-19 vaccine. Data extraction and synthesis Two reviewers independently conducted screening and data extraction. The rate of myo/pericarditis among vaccinated and unvaccinated groups was recorded, and the rate ratios were calculated. Additionally, the total number of individuals, case ascertainment criteria, percentage of males and history of SARS-CoV-2 infection were extracted for each study. Meta-analysis was done using a randomeffects model. Results Seven studies met the inclusion criteria, of which six were included in the quantitative synthesis. Our metaanalysis indicates that within 30-day follow-up period, vaccinated individuals were twice as likely to develop myo/pericarditis in the absence of SARS-CoV-2 infection compared to unvaccinated individuals, with a rate ratio of 2.05 (95% CI 1.49–2.82). Conclusion Although the absolute number of observed myo/pericarditis cases remains quite low, a higher risk was detected in those who received mRNA COVID-19 vaccinations compared with unvaccinated individuals in the absence of SARS-CoV-2 infection. Given the effectiveness of mRNA COVID-19 vaccines in preventing severe illnesses, hospitalisations and deaths, future research should focus on accurately determining the rates of myo/pericarditis linked to mRNA COVID-19 vaccines, understanding the biological mechanisms behind these rare cardiac events and identifying those most at risk. 2023-10-24T13:54:59Z 2023-10-24T13:54:59Z 2023 Artículo Alami, A. et al. Risk of myocarditis and pericarditis in mRNA COVID-19-vaccinated and unvaccinated populations: a systematic review and meta-analysis [en línea]. BMJ Open. 2023, 13(6):e065687. doi: 10.1136/bmjopen-2022-065687. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/17346 2044-6055 https://repositorio.uca.edu.ar/handle/123456789/17346 10.1136/bmjopen-2022-065687 eng Acceso abierto http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf BMJ Publishing Group BMJ Open Vol.13, No.6: e065687, 2023 |
| institution |
Universidad Católica Argentina |
| institution_str |
I-33 |
| repository_str |
R-139 |
| collection |
Repositorio Institucional de la Universidad Católica Argentina (UCA) |
| language |
Inglés |
| topic |
COVID-19 EPIDEMIOLOGIA SALUD PUBLICA. MIOCARDITIS PERICARDITIS |
| spellingShingle |
COVID-19 EPIDEMIOLOGIA SALUD PUBLICA. MIOCARDITIS PERICARDITIS Alami, Abdallah Krewski, Daniel Farhat, Nawal Mattison, Donald Wilson, Kumanan Gravel, Christopher A. Farrell, Patrick J. Crispo, James A. G. Pérez Lloret, Santiago Villeneuve, Paul J. Haddad, Nisrine Risk of myocarditis and pericarditis in mRNA COVID-19-vaccinated and unvaccinated populations: a systematic review and meta-analysis |
| topic_facet |
COVID-19 EPIDEMIOLOGIA SALUD PUBLICA. MIOCARDITIS PERICARDITIS |
| description |
Abstract: Objective To summarise the available evidence on the
risk of myocarditis and/or pericarditis following mRNA
COVID-19 vaccination, compared with the risk among
unvaccinated individuals in the absence of COVID-19
infection.
Design Systematic review and meta-analysis.
Data sources Electronic databases (Medline, Embase,
Web of Science and WHO Global Literature on Coronavirus
Disease), preprint repositories (medRxiv and bioRxiv),
reference lists and grey literature were searched from 1
December 2020 until 31 October 2022.
Study selection Epidemiological studies of individuals
of any age who received at least one dose of an mRNA
COVID-19 vaccine, reported a risk of myo/pericarditis and
compared the risk of myo/pericarditis to individuals who
did not receive any dose of an mRNA COVID-19 vaccine.
Data extraction and synthesis Two reviewers
independently conducted screening and data extraction.
The rate of myo/pericarditis among vaccinated and
unvaccinated groups was recorded, and the rate ratios
were calculated. Additionally, the total number of
individuals, case ascertainment criteria, percentage of
males and history of SARS-CoV-2 infection were extracted
for each study. Meta-analysis was done using a randomeffects model.
Results Seven studies met the inclusion criteria, of which
six were included in the quantitative synthesis. Our metaanalysis indicates that within 30-day follow-up period,
vaccinated individuals were twice as likely to develop
myo/pericarditis in the absence of SARS-CoV-2 infection
compared to unvaccinated individuals, with a rate ratio of
2.05 (95% CI 1.49–2.82).
Conclusion Although the absolute number of observed
myo/pericarditis cases remains quite low, a higher risk
was detected in those who received mRNA COVID-19
vaccinations compared with unvaccinated individuals
in the absence of SARS-CoV-2 infection. Given the
effectiveness of mRNA COVID-19 vaccines in preventing
severe illnesses, hospitalisations and deaths, future
research should focus on accurately determining the
rates of myo/pericarditis linked to mRNA COVID-19
vaccines, understanding the biological mechanisms behind these rare cardiac events and identifying those
most at risk. |
| format |
Artículo |
| author |
Alami, Abdallah Krewski, Daniel Farhat, Nawal Mattison, Donald Wilson, Kumanan Gravel, Christopher A. Farrell, Patrick J. Crispo, James A. G. Pérez Lloret, Santiago Villeneuve, Paul J. Haddad, Nisrine |
| author_facet |
Alami, Abdallah Krewski, Daniel Farhat, Nawal Mattison, Donald Wilson, Kumanan Gravel, Christopher A. Farrell, Patrick J. Crispo, James A. G. Pérez Lloret, Santiago Villeneuve, Paul J. Haddad, Nisrine |
| author_sort |
Alami, Abdallah |
| title |
Risk of myocarditis and pericarditis in mRNA COVID-19-vaccinated and unvaccinated populations: a systematic review and meta-analysis |
| title_short |
Risk of myocarditis and pericarditis in mRNA COVID-19-vaccinated and unvaccinated populations: a systematic review and meta-analysis |
| title_full |
Risk of myocarditis and pericarditis in mRNA COVID-19-vaccinated and unvaccinated populations: a systematic review and meta-analysis |
| title_fullStr |
Risk of myocarditis and pericarditis in mRNA COVID-19-vaccinated and unvaccinated populations: a systematic review and meta-analysis |
| title_full_unstemmed |
Risk of myocarditis and pericarditis in mRNA COVID-19-vaccinated and unvaccinated populations: a systematic review and meta-analysis |
| title_sort |
risk of myocarditis and pericarditis in mrna covid-19-vaccinated and unvaccinated populations: a systematic review and meta-analysis |
| publisher |
BMJ Publishing Group |
| publishDate |
2023 |
| url |
https://repositorio.uca.edu.ar/handle/123456789/17346 |
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