24S-hydroxycholesterol: cellular effects and variations in brain diseases

Abstract The adult brain exhibit a characteristic cholesterol homeostasis, with low synthesis rate and active catabolism. Brain cholesterol turnover is possible thanks to the action of the enzyme Cytochrome P450 46A1 (CYP46A1) or 24-cholesterol hydroxylase, that transforms cholesterol into 24S-h...

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Autor principal: Sodero, Alejandro O.
Formato: Artículo
Lenguaje:Inglés
Publicado: Wiley 2020
Materias:
CEREBRO
COLESTEROL
NEURODEGENERACION
ENFERMEDAD DE ALZHEIMER
ENFERMEDAD CEREBRAL
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/10916
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina
id I33-R139123456789-10916
record_format dspace
institution Universidad Católica Argentina
institution_str I-33
repository_str R-139
collection Repositorio Institucional de la Universidad Católica Argentina (UCA)
language Inglés
topic CEREBRO
COLESTEROL
NEURODEGENERACION
ENFERMEDAD DE ALZHEIMER
ENFERMEDAD CEREBRAL
spellingShingle CEREBRO
COLESTEROL
NEURODEGENERACION
ENFERMEDAD DE ALZHEIMER
ENFERMEDAD CEREBRAL
Sodero, Alejandro O.
24S-hydroxycholesterol: cellular effects and variations in brain diseases
topic_facet CEREBRO
COLESTEROL
NEURODEGENERACION
ENFERMEDAD DE ALZHEIMER
ENFERMEDAD CEREBRAL
description Abstract The adult brain exhibit a characteristic cholesterol homeostasis, with low synthesis rate and active catabolism. Brain cholesterol turnover is possible thanks to the action of the enzyme Cytochrome P450 46A1 (CYP46A1) or 24-cholesterol hydroxylase, that transforms cholesterol into 24S-hydroxycholesterol (24S-HC). But before crossing the blood-brain barrier (BBB), this oxysterol that is the most abundant in the brain can act locally, affecting the functioning of neurons, astrocytes, oligodendrocytes, and vascular cells. The first part of this review addresses different aspects of 24SHC production and elimination from the brain. The second part concentrates in the effects of 24S-HC at the cellular level, describing how this oxysterol affects cell viability, amyloid β production, neurotransmission, and transcriptional activity. Finally, the role of 24S-HC in Alzheimer, Huntington and Parkinson diseases, multiple sclerosis and amyotrophic lateral sclerosis, as well as the possibility of using this oxysterol as predictive and/or evolution biomarker in different brain disorders is discussed.
format Artículo
author Sodero, Alejandro O.
author_facet Sodero, Alejandro O.
author_sort Sodero, Alejandro O.
title 24S-hydroxycholesterol: cellular effects and variations in brain diseases
title_short 24S-hydroxycholesterol: cellular effects and variations in brain diseases
title_full 24S-hydroxycholesterol: cellular effects and variations in brain diseases
title_fullStr 24S-hydroxycholesterol: cellular effects and variations in brain diseases
title_full_unstemmed 24S-hydroxycholesterol: cellular effects and variations in brain diseases
title_sort 24s-hydroxycholesterol: cellular effects and variations in brain diseases
publisher Wiley
publishDate 2020
url https://repositorio.uca.edu.ar/handle/123456789/10916
work_keys_str_mv AT soderoalejandroo 24shydroxycholesterolcellulareffectsandvariationsinbraindiseases
bdutipo_str Repositorios
_version_ 1764820525157187584

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