TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice

Abstract: Excess production of reactive oxygen species (ROS) caused by hyperglycemia is a major risk factor for heart failure. We previously reported that transient receptor potential canonical 3 (TRPC3) channel mediates pressure overload-induced maladaptive cardiac fibrosis by forming stably functi...

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Detalles Bibliográficos
Autores principales: Oda, Sayaka, Numaga-Tomita, Takuro, Kitajima, Naoyuki, Toyama, Takashi, Harada, Eri, Shimauchi, Tsukasa, Nishimura, Akiyuki, Ishikawa, Tatsuya, Kumagai, Yoshito, Birnbaumer, Lutz, Nishida, Motohiro
Formato: Artículo
Lenguaje:Inglés
Publicado: Nature Research 2019
Materias:
HIPERGLUCEMIA
FIBROSIS
CORAZON
Acceso en línea:https://repositorio.uca.edu.ar/handle/123456789/8722
Aporte de:
Repositorio Institucional de la Universidad Católica Argentina (UCA) de Universidad Católica Argentina

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