Uterus transplantation in a sheep model: Novel surgical technique with long-term survival and uterus vitality. First case series in Argentina

Objective: To develop a sheep autologous uterus transplantation (UT) program with an innovative surgical technique and assess long term uterus vitality and animal survival. Methods: A novel surgical technique consisting of the procurement of the complete uterus and the two ovaries, back table vascul...

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Autores principales: Maraschio, Martín A., Larcher, José M Sad, Alcaraz, Alvaro, Giordano, Enzo, Reimondez, Santiago, Luján, Oscar, Iraci, Marcelo, Sereno, José L., Priotto, Analía, Domínguez, Olga, Valle, Pablo Esteban, Abrego, Maximiliano, Rubio, Soledad, Lamberto, Cristian, Villada, Eduardo
Formato: Artículo
Lenguaje:Español
Publicado: Sociedade Brasileira de Reproducao Assistida 2021
Materias:
QL Zoología
S Agricultura (General)
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/3310/1/A_Maraschio_Larcher_Alcaraz.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-3310
record_format dspace
spelling I38-R144-33102025-04-11T18:27:05Z http://pa.bibdigital.ucc.edu.ar/3310/ Uterus transplantation in a sheep model: Novel surgical technique with long-term survival and uterus vitality. First case series in Argentina Maraschio, Martín A. Larcher, José M Sad Alcaraz, Alvaro Giordano, Enzo Reimondez, Santiago Luján, Oscar Iraci, Marcelo Sereno, José L. Priotto, Analía Domínguez, Olga Valle, Pablo Esteban Abrego, Maximiliano Rubio, Soledad Lamberto, Cristian Villada, Eduardo QL Zoología S Agricultura (General) Objective: To develop a sheep autologous uterus transplantation (UT) program with an innovative surgical technique and assess long term uterus vitality and animal survival. Methods: A novel surgical technique consisting of the procurement of the complete uterus and the two ovaries, back table vascular reconstruction, and subsequent implantation in the same animal, performing only two arterial and two venous anastomoses. Results: Four autologous transplantations were performed; anesthesia and surgery were well tolerated by all the animals without complications. Direct observation and Doppler US performed a week after UT and laparoscopy performed three months later confirmed uterus vitality. All animals were alive more than a year after transplantation. Conclusions: Our study was the first to describe a novel surgical technique for sheep uterus autologous transplantation in Latin America, showing long-term survival and uterus vitality. Sociedade Brasileira de Reproducao Assistida 2021 info:eu-repo/semantics/article info:eu-repo/semantics/closedAccess application/pdf spa http://pa.bibdigital.ucc.edu.ar/3310/1/A_Maraschio_Larcher_Alcaraz.pdf Maraschio, Martín A., Larcher, José M Sad, Alcaraz, Alvaro, Giordano, Enzo, Reimondez, Santiago, Luján, Oscar, Iraci, Marcelo, Sereno, José L., Priotto, Analía, Domínguez, Olga, Valle, Pablo Esteban ORCID: https://orcid.org/0000-0002-0561-3493 <https://orcid.org/0000-0002-0561-3493>, Abrego, Maximiliano, Rubio, Soledad, Lamberto, Cristian and Villada, Eduardo (2021) Uterus transplantation in a sheep model: Novel surgical technique with long-term survival and uterus vitality. First case series in Argentina. Jornal Brasileiro de Reproducao Assistida, 25 (4). pp. 557-562. ISSN 1517-5693 file:///C:/Users/milena.brusa/Downloads/7-1720-Uterus.pdf info:eu-repo/semantics/altIdentifier/doi/10.5935/1518-0557.20210035
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic QL Zoología
S Agricultura (General)
spellingShingle QL Zoología
S Agricultura (General)
Maraschio, Martín A.
Larcher, José M Sad
Alcaraz, Alvaro
Giordano, Enzo
Reimondez, Santiago
Luján, Oscar
Iraci, Marcelo
Sereno, José L.
Priotto, Analía
Domínguez, Olga
Valle, Pablo Esteban
Abrego, Maximiliano
Rubio, Soledad
Lamberto, Cristian
Villada, Eduardo
Uterus transplantation in a sheep model: Novel surgical technique with long-term survival and uterus vitality. First case series in Argentina
topic_facet QL Zoología
S Agricultura (General)
description Objective: To develop a sheep autologous uterus transplantation (UT) program with an innovative surgical technique and assess long term uterus vitality and animal survival. Methods: A novel surgical technique consisting of the procurement of the complete uterus and the two ovaries, back table vascular reconstruction, and subsequent implantation in the same animal, performing only two arterial and two venous anastomoses. Results: Four autologous transplantations were performed; anesthesia and surgery were well tolerated by all the animals without complications. Direct observation and Doppler US performed a week after UT and laparoscopy performed three months later confirmed uterus vitality. All animals were alive more than a year after transplantation. Conclusions: Our study was the first to describe a novel surgical technique for sheep uterus autologous transplantation in Latin America, showing long-term survival and uterus vitality.
format Artículo
author Maraschio, Martín A.
Larcher, José M Sad
Alcaraz, Alvaro
Giordano, Enzo
Reimondez, Santiago
Luján, Oscar
Iraci, Marcelo
Sereno, José L.
Priotto, Analía
Domínguez, Olga
Valle, Pablo Esteban
Abrego, Maximiliano
Rubio, Soledad
Lamberto, Cristian
Villada, Eduardo
author_facet Maraschio, Martín A.
Larcher, José M Sad
Alcaraz, Alvaro
Giordano, Enzo
Reimondez, Santiago
Luján, Oscar
Iraci, Marcelo
Sereno, José L.
Priotto, Analía
Domínguez, Olga
Valle, Pablo Esteban
Abrego, Maximiliano
Rubio, Soledad
Lamberto, Cristian
Villada, Eduardo
author_sort Maraschio, Martín A.
title Uterus transplantation in a sheep model: Novel surgical technique with long-term survival and uterus vitality. First case series in Argentina
title_short Uterus transplantation in a sheep model: Novel surgical technique with long-term survival and uterus vitality. First case series in Argentina
title_full Uterus transplantation in a sheep model: Novel surgical technique with long-term survival and uterus vitality. First case series in Argentina
title_fullStr Uterus transplantation in a sheep model: Novel surgical technique with long-term survival and uterus vitality. First case series in Argentina
title_full_unstemmed Uterus transplantation in a sheep model: Novel surgical technique with long-term survival and uterus vitality. First case series in Argentina
title_sort uterus transplantation in a sheep model: novel surgical technique with long-term survival and uterus vitality. first case series in argentina
publisher Sociedade Brasileira de Reproducao Assistida
publishDate 2021
url http://pa.bibdigital.ucc.edu.ar/3310/1/A_Maraschio_Larcher_Alcaraz.pdf
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