Percutaneous ethanol injection therapy in post-transplant patients with secondary hyperparathyroidism

Persistent hyperparathyroidism is frequent in postrenal transplant patients. Percutaneous ethanol injection therapy (PEIT) is an alternative for treatment of patients with secondary hyperparathyroidism but it was not described in postrenal transplant patients. We report our experience with PEIT to c...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Douthat, Walter Guillermo, Orozco, Santiago E., Maino, Pablo, Cardozo, Gabriela, Arteaga, Javier de, Fuente, Jorge de la, Chirchiu, Carlos R., Massari, Pablo U.
Formato:	Artículo
Lenguaje:	Español
Publicado:	2007
Materias:	R Medicina (General)
Acceso en línea:	http://pa.bibdigital.ucc.edu.ar/4013/1/A_Douthat_Orozco_Maino_Cardozo_Arteaga_Fuente_Chirchiu_Massari.pdf
Aporte de:	Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba

id	I38-R144-4013
record_format	dspace
spelling	I38-R144-40132025-04-09T22:03:41Z http://pa.bibdigital.ucc.edu.ar/4013/ Percutaneous ethanol injection therapy in post-transplant patients with secondary hyperparathyroidism Douthat, Walter Guillermo Orozco, Santiago E. Maino, Pablo Cardozo, Gabriela Arteaga, Javier de Fuente, Jorge de la Chirchiu, Carlos R. Massari, Pablo U. R Medicina (General) Persistent hyperparathyroidism is frequent in postrenal transplant patients. Percutaneous ethanol injection therapy (PEIT) is an alternative for treatment of patients with secondary hyperparathyroidism but it was not described in postrenal transplant patients. We report our experience with PEIT to control hyperparathyroidism in the post-transplant period. We performed PEIT under ultrasonographic guidance and local anesthesia in eight patients because of persistent secondary hyperparathyroidism after renal transplantation. Indications for PEIT were: high intact parathyroid hormone (iPTH) levels with hypercalcemia, hypophosphatemia, osteopenia and/or bone pain. All patients had at least one visible parathyroid nodule by ultrasonography. Biochemical assays were performed immediately before PEIT, between 1 and 7 days after last PEIT, and a mean of 8.0 ± 2.8 months after PEIT. Serum iPTH and calcium levels decreased significantly after treatment and remained unchanged until final control. Serum iPTH decreased from 286.9 ± 107.2 to 154.6 ± 42.2 pg/ml (P < 0.01) after PEIT (percentual reduction 36.5 ± 9.5%). This response was significantly correlated to total ethanol volume used (r: 0.94, P < 0.0001). Hypercalcemia disappeared in six of eight patients treated. Only minor complications were registered. There were no changes in renal function related to the treatment. Our findings show that PEIT is a useful and safe alternative for patients with persistent post-transplant secondary hyperparathyroidism. 2007-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/closedAccess application/pdf spa http://pa.bibdigital.ucc.edu.ar/4013/1/A_Douthat_Orozco_Maino_Cardozo_Arteaga_Fuente_Chirchiu_Massari.pdf Douthat, Walter Guillermo ORCID: https://orcid.org/0000-0002-4644-6003 <https://orcid.org/0000-0002-4644-6003>, Orozco, Santiago E., Maino, Pablo, Cardozo, Gabriela, Arteaga, Javier de, Fuente, Jorge de la, Chirchiu, Carlos R. and Massari, Pablo U. (2007) Percutaneous ethanol injection therapy in post-transplant patients with secondary hyperparathyroidism. Transplant International, 20 (12). pp. 1031-1035. ISSN 1432-2277 info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1432-2277.2007.00545.x
institution	Universidad Católica de Córdoba
institution_str	I-38
repository_str	R-144
collection	Producción Académica Universidad Católica de Córdoba (UCCor)
language	Español
orig_language_str_mv	spa
topic	R Medicina (General)
spellingShingle	R Medicina (General) Douthat, Walter Guillermo Orozco, Santiago E. Maino, Pablo Cardozo, Gabriela Arteaga, Javier de Fuente, Jorge de la Chirchiu, Carlos R. Massari, Pablo U. Percutaneous ethanol injection therapy in post-transplant patients with secondary hyperparathyroidism
topic_facet	R Medicina (General)
description	Persistent hyperparathyroidism is frequent in postrenal transplant patients. Percutaneous ethanol injection therapy (PEIT) is an alternative for treatment of patients with secondary hyperparathyroidism but it was not described in postrenal transplant patients. We report our experience with PEIT to control hyperparathyroidism in the post-transplant period. We performed PEIT under ultrasonographic guidance and local anesthesia in eight patients because of persistent secondary hyperparathyroidism after renal transplantation. Indications for PEIT were: high intact parathyroid hormone (iPTH) levels with hypercalcemia, hypophosphatemia, osteopenia and/or bone pain. All patients had at least one visible parathyroid nodule by ultrasonography. Biochemical assays were performed immediately before PEIT, between 1 and 7 days after last PEIT, and a mean of 8.0 ± 2.8 months after PEIT. Serum iPTH and calcium levels decreased significantly after treatment and remained unchanged until final control. Serum iPTH decreased from 286.9 ± 107.2 to 154.6 ± 42.2 pg/ml (P < 0.01) after PEIT (percentual reduction 36.5 ± 9.5%). This response was significantly correlated to total ethanol volume used (r: 0.94, P < 0.0001). Hypercalcemia disappeared in six of eight patients treated. Only minor complications were registered. There were no changes in renal function related to the treatment. Our findings show that PEIT is a useful and safe alternative for patients with persistent post-transplant secondary hyperparathyroidism.
format	Artículo
author	Douthat, Walter Guillermo Orozco, Santiago E. Maino, Pablo Cardozo, Gabriela Arteaga, Javier de Fuente, Jorge de la Chirchiu, Carlos R. Massari, Pablo U.
author_facet	Douthat, Walter Guillermo Orozco, Santiago E. Maino, Pablo Cardozo, Gabriela Arteaga, Javier de Fuente, Jorge de la Chirchiu, Carlos R. Massari, Pablo U.
author_sort	Douthat, Walter Guillermo
title	Percutaneous ethanol injection therapy in post-transplant patients with secondary hyperparathyroidism
title_short	Percutaneous ethanol injection therapy in post-transplant patients with secondary hyperparathyroidism
title_full	Percutaneous ethanol injection therapy in post-transplant patients with secondary hyperparathyroidism
title_fullStr	Percutaneous ethanol injection therapy in post-transplant patients with secondary hyperparathyroidism
title_full_unstemmed	Percutaneous ethanol injection therapy in post-transplant patients with secondary hyperparathyroidism
title_sort	percutaneous ethanol injection therapy in post-transplant patients with secondary hyperparathyroidism
publishDate	2007
url	http://pa.bibdigital.ucc.edu.ar/4013/1/A_Douthat_Orozco_Maino_Cardozo_Arteaga_Fuente_Chirchiu_Massari.pdf
work_keys_str_mv	AT douthatwalterguillermo percutaneousethanolinjectiontherapyinposttransplantpatientswithsecondaryhyperparathyroidism AT orozcosantiagoe percutaneousethanolinjectiontherapyinposttransplantpatientswithsecondaryhyperparathyroidism AT mainopablo percutaneousethanolinjectiontherapyinposttransplantpatientswithsecondaryhyperparathyroidism AT cardozogabriela percutaneousethanolinjectiontherapyinposttransplantpatientswithsecondaryhyperparathyroidism AT arteagajavierde percutaneousethanolinjectiontherapyinposttransplantpatientswithsecondaryhyperparathyroidism AT fuentejorgedela percutaneousethanolinjectiontherapyinposttransplantpatientswithsecondaryhyperparathyroidism AT chirchiucarlosr percutaneousethanolinjectiontherapyinposttransplantpatientswithsecondaryhyperparathyroidism AT massaripablou percutaneousethanolinjectiontherapyinposttransplantpatientswithsecondaryhyperparathyroidism
_version_	1832592428473778176

Percutaneous ethanol injection therapy in post-transplant patients with secondary hyperparathyroidism

Ejemplares similares