Expanded criteria donors, histological scoring, and prolonged cold ischemia: Impact on renal graft survival

The use of expanded donors or kidneys with preexistent chronic damage remains controversial, but they offer the opportunity to expand the donor pool. We investigated the impact of these conditions as predictors of graft survival among a cohort of recipients with prolonged cold ischemia times and a h...

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Autores principales: Chiurchiu, Carlos, Riva, V., Brgesser, M.V., De Arteaga, J., Douthat, Walter Guillermo, De La Fuente, Jorge, De Diller, A.B., Massari, Pablo U.
Formato: Artículo PeerReviewed
Lenguaje:Español
Publicado: 2011
Materias:
R Medicina (General)
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/5022/1/A_Chiurchiu.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-5022
record_format dspace
spelling I38-R144-50222025-11-14T15:04:55Z http://pa.bibdigital.ucc.edu.ar/5022/ Expanded criteria donors, histological scoring, and prolonged cold ischemia: Impact on renal graft survival Chiurchiu, Carlos Riva, V. Brgesser, M.V. De Arteaga, J. Douthat, Walter Guillermo De La Fuente, Jorge De Diller, A.B. Massari, Pablo U. R Medicina (General) The use of expanded donors or kidneys with preexistent chronic damage remains controversial, but they offer the opportunity to expand the donor pool. We investigated the impact of these conditions as predictors of graft survival among a cohort of recipients with prolonged cold ischemia times and a high incidence of delayed graft function. We included 70 consecutive cadaveric kidney allografts implanted between 2001 and 2005, which had undergone an early graft biopsy. Delayed graft function was present in 84% of cases with moderate or severe preexistent chronic damage in 63% and 27% of biopsies, respectively, and acute rejection was diagnosed in 14.3% of overall cases. The graft survival was 73.3% at 48 months. Primary nonfunctioning kidneys were more frequent using kidneys from expanded compared with standard donors (20.0% vs 0.0%, P <.002). Multivariate analysis showed that only the donor condition (standard vs expanded) was independently associated with graft survival (hazard ratio: 0.12; 95% confidence interval: 0.010.87; P <.03). Our results suggested that the donor characteristics prevail over other variables to predict graft outcomes. 2011-12-31 Artículo PeerReviewed application/pdf spa http://pa.bibdigital.ucc.edu.ar/5022/1/A_Chiurchiu.pdf Chiurchiu, Carlos, Riva, V., Brgesser, M.V., De Arteaga, J., Douthat, Walter Guillermo ORCID: https://orcid.org/0000-0002-4644-6003 <https://orcid.org/0000-0002-4644-6003>, De La Fuente, Jorge, De Diller, A.B. and Massari, Pablo U. (2011) Expanded criteria donors, histological scoring, and prolonged cold ischemia: Impact on renal graft survival. Transplantation Proceedings, 43 (9). pp. 3312-3314. ISSN 18732623 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.transproceed.2011.09.085
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic R Medicina (General)
spellingShingle R Medicina (General)
Chiurchiu, Carlos
Riva, V.
Brgesser, M.V.
De Arteaga, J.
Douthat, Walter Guillermo
De La Fuente, Jorge
De Diller, A.B.
Massari, Pablo U.
Expanded criteria donors, histological scoring, and prolonged cold ischemia: Impact on renal graft survival
topic_facet R Medicina (General)
description The use of expanded donors or kidneys with preexistent chronic damage remains controversial, but they offer the opportunity to expand the donor pool. We investigated the impact of these conditions as predictors of graft survival among a cohort of recipients with prolonged cold ischemia times and a high incidence of delayed graft function. We included 70 consecutive cadaveric kidney allografts implanted between 2001 and 2005, which had undergone an early graft biopsy. Delayed graft function was present in 84% of cases with moderate or severe preexistent chronic damage in 63% and 27% of biopsies, respectively, and acute rejection was diagnosed in 14.3% of overall cases. The graft survival was 73.3% at 48 months. Primary nonfunctioning kidneys were more frequent using kidneys from expanded compared with standard donors (20.0% vs 0.0%, P <.002). Multivariate analysis showed that only the donor condition (standard vs expanded) was independently associated with graft survival (hazard ratio: 0.12; 95% confidence interval: 0.010.87; P <.03). Our results suggested that the donor characteristics prevail over other variables to predict graft outcomes.
format Artículo
PeerReviewed
author Chiurchiu, Carlos
Riva, V.
Brgesser, M.V.
De Arteaga, J.
Douthat, Walter Guillermo
De La Fuente, Jorge
De Diller, A.B.
Massari, Pablo U.
author_facet Chiurchiu, Carlos
Riva, V.
Brgesser, M.V.
De Arteaga, J.
Douthat, Walter Guillermo
De La Fuente, Jorge
De Diller, A.B.
Massari, Pablo U.
author_sort Chiurchiu, Carlos
title Expanded criteria donors, histological scoring, and prolonged cold ischemia: Impact on renal graft survival
title_short Expanded criteria donors, histological scoring, and prolonged cold ischemia: Impact on renal graft survival
title_full Expanded criteria donors, histological scoring, and prolonged cold ischemia: Impact on renal graft survival
title_fullStr Expanded criteria donors, histological scoring, and prolonged cold ischemia: Impact on renal graft survival
title_full_unstemmed Expanded criteria donors, histological scoring, and prolonged cold ischemia: Impact on renal graft survival
title_sort expanded criteria donors, histological scoring, and prolonged cold ischemia: impact on renal graft survival
publishDate 2011
url http://pa.bibdigital.ucc.edu.ar/5022/1/A_Chiurchiu.pdf
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AT rivav expandedcriteriadonorshistologicalscoringandprolongedcoldischemiaimpactonrenalgraftsurvival
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