Use of drugs in pregnant canine
Physiological changes during pregnancy induce profound alterations in the pharmacokinetic properties of many drugs. These changes affect the distribution, absorption, metabolism, and excretion of drugs and therefore may affect their pharmacodynamic properties. An understanding of both the physiolog...
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional del Nordeste
2023
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| Acceso en línea: | https://revistas.unne.edu.ar/index.php/vet/article/view/6613 |
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I48-R154-article-66132023-06-05T13:03:26Z Use of drugs in pregnant canine Uso de fármacos en la hembra canina preñada Landoni, M. F. Pregnancy canines therapeutic physiological alterations ADME Preñez caninos terapéutica modificaciones fisiológicas ADME Physiological changes during pregnancy induce profound alterations in the pharmacokinetic properties of many drugs. These changes affect the distribution, absorption, metabolism, and excretion of drugs and therefore may affect their pharmacodynamic properties. An understanding of both the physiology of pregnancy and the specific pharmacology of the different agents is necessary to achieve effective treatment and limit maternal and fetal risk. Unfortunately, most drug studies exclude pregnant females, even when there are pathological entities that need to be treated during pregnancy (pain, infectious processes, etc). This review begins with a reminder of the basic concepts of pharmacokinetics and their clinical relevance. Physiological changes in pregnancy and their consequences on the pharmacokinetic and pharmacodynamic properties of many drugs are described. As a closure, the therapeutic categories most commonly indicated in pregnant females are discussed. Los cambios fisiológicos en la preñez inducen alteraciones profundas en las propiedades farmacocinéticas de muchos medicamentos. Estos cambios afectan la absorción, la distribución, el metabolismo y la excreción de los fármacos y, por lo tanto, pueden afectar sus propiedades farmacodinámicas. Es necesario comprender tanto la fisiología de la preñez como la farmacología específica de los diferentes agentes para lograr un tratamiento eficaz y limitar el riesgo materno y fetal. Desafortunadamente, la mayoría de los estudios de medicamentos excluyen a las hembras preñadas, aún cuando existen entidades patológicas que requieren ser tratadas durante la preñez (dolor, procesos infecciosos, etc). Esta revisión se inicia con un recordatorio de los conceptos básicos de farmacocinética y su relevancia clínica. Se describen los cambios fisiológicos durante la preñez y sus consecuencias en las propiedades farmacocinéticas y farmacodinámicas de muchos medicamentos. Como cierre, se analizan de manera particular las categorías terapéuticas más comúnmente indicadas en hembras preñadas. Universidad Nacional del Nordeste 2023-06-05 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unne.edu.ar/index.php/vet/article/view/6613 10.30972/vet.3416613 Revista Veterinaria; Vol. 34 Núm. 1 (2023); 67-76 1669-6840 1668-4834 spa https://revistas.unne.edu.ar/index.php/vet/article/view/6613/6153 Derechos de autor 2023 Revista Veterinaria |
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Universidad Nacional del Nordeste |
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I-48 |
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R-154 |
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Revistas UNNE - Universidad Nacional del Noroeste (UNNE) |
| language |
Español |
| format |
Artículo revista |
| topic |
Pregnancy canines therapeutic physiological alterations ADME Preñez caninos terapéutica modificaciones fisiológicas ADME |
| spellingShingle |
Pregnancy canines therapeutic physiological alterations ADME Preñez caninos terapéutica modificaciones fisiológicas ADME Landoni, M. F. Use of drugs in pregnant canine |
| topic_facet |
Pregnancy canines therapeutic physiological alterations ADME Preñez caninos terapéutica modificaciones fisiológicas ADME |
| author |
Landoni, M. F. |
| author_facet |
Landoni, M. F. |
| author_sort |
Landoni, M. F. |
| title |
Use of drugs in pregnant canine |
| title_short |
Use of drugs in pregnant canine |
| title_full |
Use of drugs in pregnant canine |
| title_fullStr |
Use of drugs in pregnant canine |
| title_full_unstemmed |
Use of drugs in pregnant canine |
| title_sort |
use of drugs in pregnant canine |
| description |
Physiological changes during pregnancy induce profound alterations in the pharmacokinetic properties of many drugs. These changes affect the distribution, absorption, metabolism, and excretion of drugs and therefore may affect their pharmacodynamic properties. An understanding of both the physiology of pregnancy and the specific pharmacology of the different agents is necessary to achieve effective treatment and limit maternal and fetal risk. Unfortunately, most drug studies exclude pregnant females, even when there are pathological entities that need to be treated during pregnancy (pain, infectious processes, etc). This review begins with a reminder of the basic concepts of pharmacokinetics and their clinical relevance. Physiological changes in pregnancy and their consequences on the pharmacokinetic and pharmacodynamic properties of many drugs are described. As a closure, the therapeutic categories most commonly indicated in pregnant females are discussed. |
| publisher |
Universidad Nacional del Nordeste |
| publishDate |
2023 |
| url |
https://revistas.unne.edu.ar/index.php/vet/article/view/6613 |
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2024-08-21T22:35:50Z |
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