Equine Parvovirus-Hepatitis: A new adventitious agent in veterinary biological products
Equine Parvovirus-Hepatitis (EqPV-H) is a new member of Parvoviridae family discovered 5 years ago. This virus was first identified in the serum and liver of a horse that died of equine serum hepatitis, also known as Theiler’s disease. This disease is one of the most common causes of acute hepatitis...
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| Formato: | Artículo revista |
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Universidad Nacional del Nordeste
2023
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| Acceso en línea: | https://revistas.unne.edu.ar/index.php/vet/article/view/7058 |
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I48-R154-article-70582023-11-28T12:58:47Z Equine Parvovirus-Hepatitis: A new adventitious agent in veterinary biological products Parvovirus Equino-Hepatitis (EqPV-H): un nuevo virus contaminante de productos biológicos de origen veterinario Ruiz, V. Alvarez, I. Equine Parvovirus-Hepatitis Theiler´s disease biological products contamination Parvovirus Equino-Hepatitis enfermedad de Theiler productos biológicos contaminación Equine Parvovirus-Hepatitis (EqPV-H) is a new member of Parvoviridae family discovered 5 years ago. This virus was first identified in the serum and liver of a horse that died of equine serum hepatitis, also known as Theiler’s disease. This disease is one of the most common causes of acute hepatitis and liver failure in horses and has been frequently described after the administration of a biological product of equine origin. Several reports in recent years strongly suggest that EqPV-H is the etiologic agent of Theiler’s disease. The infection is usually asymptomatic, so infected horses can be healthy carriers and serve as reservoirs for infection to other horses. EqPV-H infection has been detected in America, Europe, Asia and Oceania, with a DNA prevalence of 3.2-19.8% and a seroprevalence of 15-34% in clinically healthy horses, reaching values of 90-100% in animals with Theiler’s disease. EqPV-H DNA has also been detected in commercial equine serum pools, revealing the risk of transmission by biological products that use this serum in their manufacturing process. Recently, the Center for Veterinary Biologics of the United States Department of Agriculture requires that all commercially licensed equine serum or plasma biologicals be tested and confirmed negative for EqPV-H. These sanitary restrictions could also be implemented in other countries. This article summarizes the published knowledge to date on EqPV-H, a focus of rapidly evolving research. El Parvovirus Equino-Hepatitis (EqPV-H) es un nuevo integrante de la familia Parvoviridae descubierto hace apenas 5 años. Este virus fue identificado en el suero e hígado de un caballo muerto por hepatitis sérica equina, también conocida como enfermedad de Theiler. Esta enfermedad es una de las causas más comunes de hepatitis aguda y falla hepática en caballos y se ha descripto frecuentemente luego de la administración de algún producto biológico de origen equino. Numerosos reportes en los últimos años sugieren fuertemente que el EqPV-H es el agente etiológico de la enfermedad de Theiler. Comúnmente la infección es asintomática por lo que los caballos infectados pueden ser portadores sanos y servir como reservorios para la infección de otros caballos. La infección por EqPV-H fue detectada en América, Europa, Asia y Oceanía, con una prevalencia de ADN del 3,2-19,8% y una seroprevalencia de 15-34% en caballos clínicamente sanos, alcanzando valores del 90-100% en animales con enfermedad de Theiler. Se ha reportado también la presencia de ADN de EqPV-H en lotes de suero equino comercial, evidenciando el riesgo de transmisión por productos biológicos que utilicen este insumo en su proceso de manufactura. Recientemente, el Centro de Biológicos Veterinarios del Departamento de Agricultura de Estados Unidos ha establecido que todos los productos biológicos de plasma o suero equino con licencia comercial deben ser analizados y resultar negativos para EqPV-H. Probablemente, estas restricciones sanitarias comiencen a implementarse en otros países. Este artículo resume el conocimiento publicado hasta la fecha sobre el EqPV-H, objeto de una investigación en rápida evolución. Universidad Nacional del Nordeste 2023-11-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unne.edu.ar/index.php/vet/article/view/7058 10.30972/vet.3427058 Revista Veterinaria; Vol. 34 Núm. 2 (2023); 134-141 1669-6840 1668-4834 spa https://revistas.unne.edu.ar/index.php/vet/article/view/7058/6511 https://creativecommons.org/licenses/by/2.5/ar/ |
| institution |
Universidad Nacional del Nordeste |
| institution_str |
I-48 |
| repository_str |
R-154 |
| container_title_str |
Revistas UNNE - Universidad Nacional del Noroeste (UNNE) |
| language |
Español |
| format |
Artículo revista |
| topic |
Equine Parvovirus-Hepatitis Theiler´s disease biological products contamination Parvovirus Equino-Hepatitis enfermedad de Theiler productos biológicos contaminación |
| spellingShingle |
Equine Parvovirus-Hepatitis Theiler´s disease biological products contamination Parvovirus Equino-Hepatitis enfermedad de Theiler productos biológicos contaminación Ruiz, V. Alvarez, I. Equine Parvovirus-Hepatitis: A new adventitious agent in veterinary biological products |
| topic_facet |
Equine Parvovirus-Hepatitis Theiler´s disease biological products contamination Parvovirus Equino-Hepatitis enfermedad de Theiler productos biológicos contaminación |
| author |
Ruiz, V. Alvarez, I. |
| author_facet |
Ruiz, V. Alvarez, I. |
| author_sort |
Ruiz, V. |
| title |
Equine Parvovirus-Hepatitis: A new adventitious agent in veterinary biological products |
| title_short |
Equine Parvovirus-Hepatitis: A new adventitious agent in veterinary biological products |
| title_full |
Equine Parvovirus-Hepatitis: A new adventitious agent in veterinary biological products |
| title_fullStr |
Equine Parvovirus-Hepatitis: A new adventitious agent in veterinary biological products |
| title_full_unstemmed |
Equine Parvovirus-Hepatitis: A new adventitious agent in veterinary biological products |
| title_sort |
equine parvovirus-hepatitis: a new adventitious agent in veterinary biological products |
| description |
Equine Parvovirus-Hepatitis (EqPV-H) is a new member of Parvoviridae family discovered 5 years ago. This virus was first identified in the serum and liver of a horse that died of equine serum hepatitis, also known as Theiler’s disease. This disease is one of the most common causes of acute hepatitis and liver failure in horses and has been frequently described after the administration of a biological product of equine origin. Several reports in recent years strongly suggest that EqPV-H is the etiologic agent of Theiler’s disease. The infection is usually asymptomatic, so infected horses can be healthy carriers and serve as reservoirs for infection to other horses. EqPV-H infection has been detected in America, Europe, Asia and Oceania, with a DNA prevalence of 3.2-19.8% and a seroprevalence of 15-34% in clinically healthy horses, reaching values of 90-100% in animals with Theiler’s disease. EqPV-H DNA has also been detected in commercial equine serum pools, revealing the risk of transmission by biological products that use this serum in their manufacturing process. Recently, the Center for Veterinary Biologics of the United States Department of Agriculture requires that all commercially licensed equine serum or plasma biologicals be tested and confirmed negative for EqPV-H. These sanitary restrictions could also be implemented in other countries. This article summarizes the published knowledge to date on EqPV-H, a focus of rapidly evolving research. |
| publisher |
Universidad Nacional del Nordeste |
| publishDate |
2023 |
| url |
https://revistas.unne.edu.ar/index.php/vet/article/view/7058 |
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2024-08-21T22:35:55Z |
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2024-08-21T22:35:55Z |
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