South American snake venoms with abundant neurotoxic components. Composition and toxicological properties. A literature review

In South America there are three snake genera with predominantly neurotoxic venoms: Crotalus, Micrurus and Hydrophis, which include nine species/subspecies, 97 species and a single marine species, respectively. Although accidents with neurotoxic venoms are less frequent than those with anticoagula...

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Autores principales: Baudou, Federico Gastón, Rodriguez, Juan Pablo, Fusco, Luciano Sebastián, Roodt, Adolfo Rafael de, De Marzi, Mauricio Cesar, Leiva, Laura Cristina Ana
Formato: Artículo
Lenguaje:Inglés
Publicado: Elsevier B.V. 2026
Materias:
Neurotoxic venom
Crotalus
Micrurus
Hydrophis
Crotoxin
PLA2
3-FTxs
Acceso en línea:http://repositorio.unne.edu.ar/handle/123456789/60044
Aporte de:
RIUNNE - Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE) de Universidad Nacional del Nordeste
id I48-R184-123456789-60044
record_format dspace
spelling I48-R184-123456789-600442026-02-13T10:01:59Z South American snake venoms with abundant neurotoxic components. Composition and toxicological properties. A literature review Baudou, Federico Gastón Rodriguez, Juan Pablo Fusco, Luciano Sebastián Roodt, Adolfo Rafael de De Marzi, Mauricio Cesar Leiva, Laura Cristina Ana Neurotoxic venom Crotalus Micrurus Hydrophis Crotoxin PLA2 3-FTxs In South America there are three snake genera with predominantly neurotoxic venoms: Crotalus, Micrurus and Hydrophis, which include nine species/subspecies, 97 species and a single marine species, respectively. Although accidents with neurotoxic venoms are less frequent than those with anticoagulant, cytotoxic or necrotic venoms (e.g. from Bothrops), they are of major public health importance. Venoms from genus Crotalus have been extensively studied, while data on the venoms from the other two genera are very limited, especially for Hydrophis. The venoms of North and South American Crotalus species show biochemical and physiopathological differ- ences. The former species cause bothrops-like envenomation symptoms, while the latter mainly have neurotoxic and myotoxic effects, leading to respiratory paralysis and, occasionally, renal failure by myoglobinuria and death, often with no local lesions. Micrurus and Hydrophis also cause neurotoxic envenomations. Many studies have isolated, identified and characterized new enzymes and toxins, thus expanding the knowledge of snake venom composition. The present review summarizes the currently available information on neurotoxic venoms from South American snakes, with a focus on protein composition and toxicological properties. It also includes some com- ments concerning potential medical applications of elapid and crotalic toxins. 2026-02-12T19:18:26Z 2026-02-12T19:18:26Z 2021 Artículo Baudou, Federico Gastón, et al., 2021. South American snake venoms with abundant neurotoxic components. Composition and toxicological properties. A literature review. Acta Tropica. Amsterdam: Elsevier B.V., vol. 224, p. 1-19. ISSN 0001-706X. 0001-706X http://repositorio.unne.edu.ar/handle/123456789/60044 eng https://doi.org/10.1016/j.actatropica.2021.106119 closedAccess http://creativecommons.org/licenses/by-nc-nd/2.5/ar/ application/pdf p. 1-19 application/pdf Elsevier B.V. Acta Tropica, 2021, vol. 224, p. 1-19.
institution Universidad Nacional del Nordeste
institution_str I-48
repository_str R-184
collection RIUNNE - Repositorio Institucional de la Universidad Nacional del Nordeste (UNNE)
language Inglés
topic Neurotoxic venom
Crotalus
Micrurus
Hydrophis
Crotoxin
PLA2
3-FTxs
spellingShingle Neurotoxic venom
Crotalus
Micrurus
Hydrophis
Crotoxin
PLA2
3-FTxs
Baudou, Federico Gastón
Rodriguez, Juan Pablo
Fusco, Luciano Sebastián
Roodt, Adolfo Rafael de
De Marzi, Mauricio Cesar
Leiva, Laura Cristina Ana
South American snake venoms with abundant neurotoxic components. Composition and toxicological properties. A literature review
topic_facet Neurotoxic venom
Crotalus
Micrurus
Hydrophis
Crotoxin
PLA2
3-FTxs
description In South America there are three snake genera with predominantly neurotoxic venoms: Crotalus, Micrurus and Hydrophis, which include nine species/subspecies, 97 species and a single marine species, respectively. Although accidents with neurotoxic venoms are less frequent than those with anticoagulant, cytotoxic or necrotic venoms (e.g. from Bothrops), they are of major public health importance. Venoms from genus Crotalus have been extensively studied, while data on the venoms from the other two genera are very limited, especially for Hydrophis. The venoms of North and South American Crotalus species show biochemical and physiopathological differ- ences. The former species cause bothrops-like envenomation symptoms, while the latter mainly have neurotoxic and myotoxic effects, leading to respiratory paralysis and, occasionally, renal failure by myoglobinuria and death, often with no local lesions. Micrurus and Hydrophis also cause neurotoxic envenomations. Many studies have isolated, identified and characterized new enzymes and toxins, thus expanding the knowledge of snake venom composition. The present review summarizes the currently available information on neurotoxic venoms from South American snakes, with a focus on protein composition and toxicological properties. It also includes some com- ments concerning potential medical applications of elapid and crotalic toxins.
format Artículo
author Baudou, Federico Gastón
Rodriguez, Juan Pablo
Fusco, Luciano Sebastián
Roodt, Adolfo Rafael de
De Marzi, Mauricio Cesar
Leiva, Laura Cristina Ana
author_facet Baudou, Federico Gastón
Rodriguez, Juan Pablo
Fusco, Luciano Sebastián
Roodt, Adolfo Rafael de
De Marzi, Mauricio Cesar
Leiva, Laura Cristina Ana
author_sort Baudou, Federico Gastón
title South American snake venoms with abundant neurotoxic components. Composition and toxicological properties. A literature review
title_short South American snake venoms with abundant neurotoxic components. Composition and toxicological properties. A literature review
title_full South American snake venoms with abundant neurotoxic components. Composition and toxicological properties. A literature review
title_fullStr South American snake venoms with abundant neurotoxic components. Composition and toxicological properties. A literature review
title_full_unstemmed South American snake venoms with abundant neurotoxic components. Composition and toxicological properties. A literature review
title_sort south american snake venoms with abundant neurotoxic components. composition and toxicological properties. a literature review
publisher Elsevier B.V.
publishDate 2026
url http://repositorio.unne.edu.ar/handle/123456789/60044
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