Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum.

The toxicity of Nonylphenol, an emerging pollutant, on the common South American toad Rhinella arenarum was stage and time dependent, thus Median Lethal Concentrations (LC50) for acute (96 h), short-term chronic (168 h) and chronic exposure (336 h) were 1.06; 0.96 and 0.17 mgNP/L from embryonic peri...

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Autores principales: Aronzon, Carolina Mariel, Babay, Paola Alejandra, Perez Coll, Cristina Silvia
Formato: publishedVersion Artículo
Lenguaje:Inglés
Publicado: Elsevier Science Bv 2014
Materias:
AMPHIBIANS
EMBRYO-LARVAL DEVELOPMENT
STAGE-DEPENDENT SUSCEPTIBILITY
TERATOGENESIS
NONYLPHENOL
CIENCIAS BIOLÓGICAS
CIENCIAS NATURALES Y EXACTAS
Acceso en línea:https://ri.unsam.edu.ar/handle/123456789/1004
Aporte de:
Repositorio Institucional de la UNSAM de Universidad Nacional de General San Martín
id I78-R216-123456789-1004
record_format dspace
spelling I78-R216-123456789-10042023-03-27T20:43:08Z Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum. Aronzon, Carolina Mariel Babay, Paola Alejandra Perez Coll, Cristina Silvia AMPHIBIANS EMBRYO-LARVAL DEVELOPMENT STAGE-DEPENDENT SUSCEPTIBILITY TERATOGENESIS NONYLPHENOL CIENCIAS BIOLÓGICAS CIENCIAS NATURALES Y EXACTAS info:eu-repo/semantics/publishedVersion The toxicity of Nonylphenol, an emerging pollutant, on the common South American toad Rhinella arenarum was stage and time dependent, thus Median Lethal Concentrations (LC50) for acute (96 h), short-term chronic (168 h) and chronic exposure (336 h) were 1.06; 0.96 and 0.17 mgNP/L from embryonic period (S.4), whereas for exposure from larvae (S.25), LC50 remained constant at 0.37 mgNP/L from 96 h to 168 h, decreasing to 0.11 mgNP/L at 336 h. NOEC-168 h for exposure from embryos was 0.025 mgNP/L. The Teratogenic Potential (NOEC-lethality/NOEC-sublethal effects) was 23 times higher than the threshold value, indicating a high risk for embryos to be malformed in absence of significant lethality and representing a threat for the species conservation. By comparing with other amphibians, the early development of R. arenarum was very sensitive to NP. The results highlight the relevance of extending the exposure time and look for the most sensitive stage in order to perform the bioassays for conservation purposes. Fil: Aronzon, Carolina Mariel. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental; Argentina. Fil: Babay, Paola Alejandra. Comisión Nacional de Energía Atómica; Argentina Fil: Perez Coll, Cristina Silvia. Universidad Nacional de San Martín. Instituto de Investigación e Ingeniería Ambiental; Argentina 2014-08 info:eu-repo/semantics/article info:ar-repo/semantics/artículo Aronzon, C. M. ; Babay, P. A. y Perez Coll, C. S. (aug 2014) Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum; En: Environmental Toxicology and Pharmacology. Elsevier, 38 (2) 634-642 1382-6689 ETP-AM 2014 3iA A-B-PC https://ri.unsam.edu.ar/handle/123456789/1004 eng info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ Creative Commons Atribución-NoComercial-CompartirIgual 2.5 Argentina (CC BY-NC-SA 2.5) application/pdf pp. 634-642 application/pdf Elsevier Science Bv Environmental Toxicology and Pharmacology, 2014 38(2): 634-642 Elsevier Science Bv http://dx.doi.org/10.1016/j.etap.2014.08.014
institution Universidad Nacional de General San Martín
institution_str I-78
repository_str R-216
collection Repositorio Institucional de la UNSAM
language Inglés
topic AMPHIBIANS
EMBRYO-LARVAL DEVELOPMENT
STAGE-DEPENDENT SUSCEPTIBILITY
TERATOGENESIS
NONYLPHENOL
CIENCIAS BIOLÓGICAS
CIENCIAS NATURALES Y EXACTAS
spellingShingle AMPHIBIANS
EMBRYO-LARVAL DEVELOPMENT
STAGE-DEPENDENT SUSCEPTIBILITY
TERATOGENESIS
NONYLPHENOL
CIENCIAS BIOLÓGICAS
CIENCIAS NATURALES Y EXACTAS
Aronzon, Carolina Mariel
Babay, Paola Alejandra
Perez Coll, Cristina Silvia
Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum.
topic_facet AMPHIBIANS
EMBRYO-LARVAL DEVELOPMENT
STAGE-DEPENDENT SUSCEPTIBILITY
TERATOGENESIS
NONYLPHENOL
CIENCIAS BIOLÓGICAS
CIENCIAS NATURALES Y EXACTAS
description The toxicity of Nonylphenol, an emerging pollutant, on the common South American toad Rhinella arenarum was stage and time dependent, thus Median Lethal Concentrations (LC50) for acute (96 h), short-term chronic (168 h) and chronic exposure (336 h) were 1.06; 0.96 and 0.17 mgNP/L from embryonic period (S.4), whereas for exposure from larvae (S.25), LC50 remained constant at 0.37 mgNP/L from 96 h to 168 h, decreasing to 0.11 mgNP/L at 336 h. NOEC-168 h for exposure from embryos was 0.025 mgNP/L. The Teratogenic Potential (NOEC-lethality/NOEC-sublethal effects) was 23 times higher than the threshold value, indicating a high risk for embryos to be malformed in absence of significant lethality and representing a threat for the species conservation. By comparing with other amphibians, the early development of R. arenarum was very sensitive to NP. The results highlight the relevance of extending the exposure time and look for the most sensitive stage in order to perform the bioassays for conservation purposes.
format publishedVersion
Artículo
Artículo
author Aronzon, Carolina Mariel
Babay, Paola Alejandra
Perez Coll, Cristina Silvia
author_facet Aronzon, Carolina Mariel
Babay, Paola Alejandra
Perez Coll, Cristina Silvia
author_sort Aronzon, Carolina Mariel
title Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum.
title_short Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum.
title_full Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum.
title_fullStr Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum.
title_full_unstemmed Developmental toxicity and risk assessment of nonylphenol to the South American toad, Rhinella arenarum.
title_sort developmental toxicity and risk assessment of nonylphenol to the south american toad, rhinella arenarum.
publisher Elsevier Science Bv
publishDate 2014
url https://ri.unsam.edu.ar/handle/123456789/1004
work_keys_str_mv AT aronzoncarolinamariel developmentaltoxicityandriskassessmentofnonylphenoltothesouthamericantoadrhinellaarenarum
AT babaypaolaalejandra developmentaltoxicityandriskassessmentofnonylphenoltothesouthamericantoadrhinellaarenarum
AT perezcollcristinasilvia developmentaltoxicityandriskassessmentofnonylphenoltothesouthamericantoadrhinellaarenarum
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