Generation of amyloid β protein from a presenilin-1 and βAPP complex
Presenilin-1 (PS1) is a causative gene in early onset familial Alzheimer’s disease (FAD). FAD-linked mutant PS1s significantly increased Aβ40 and Aβ42(43) levels (P < 0.001) and decreased the production of an 11.4 kD (β-stub) and an 8.7 kD (α-stub) carboxyl-terminal fragment of amyloid β precurso...
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2002
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v292_n2_p571_ShizukaIkeda http://hdl.handle.net/20.500.12110/paper_0006291X_v292_n2_p571_ShizukaIkeda |
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