Major histocompatibility complex modulation of β-adrenoceptor function

Reciprocal interaction between β-adrenoceptor specific ligand occupancy and alloantibody binding to specific antigens of cardiac and smooth muscle tissues was observed. Interference of alloimmune antibody fixation to both cardiac and oviductal tract preparations by β1 or β2 selective blockers, respe...

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Publicado:	1990
Materias:	4 hydroxyoxprenolol beta adrenergic receptor butoxamine cyclic amp dihydroalprenolol immunoglobulin g monoclonal antibody practolol propranolol unclassified drug alloimmunization animal cell animal experiment article heart muscle immunofluorescence ligand binding major histocompatibility complex nonhuman priority journal smooth muscle uterine tube Animal Antibodies, Monoclonal Butoxamine Cyclic AMP Female Heart Immunoglobulin Allotypes Immunoglobulin G Ligands Major Histocompatibility Complex Mice Mice, Inbred BALB C Mice, Inbred C3H Muscle, Smooth Myocardium Practolol Propranolol Receptors, Adrenergic, beta Tritium
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062952_v39_n12_p1861_Cremaschi http://hdl.handle.net/20.500.12110/paper_00062952_v39_n12_p1861_Cremaschi
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00062952_v39_n12_p1861_Cremaschi
record_format	dspace
spelling	paper:paper_00062952_v39_n12_p1861_Cremaschi2023-06-08T14:30:32Z Major histocompatibility complex modulation of β-adrenoceptor function 4 hydroxyoxprenolol beta adrenergic receptor butoxamine cyclic amp dihydroalprenolol immunoglobulin g monoclonal antibody practolol propranolol unclassified drug alloimmunization animal cell animal experiment article heart muscle immunofluorescence ligand binding major histocompatibility complex nonhuman priority journal smooth muscle uterine tube Animal Antibodies, Monoclonal Butoxamine Cyclic AMP Female Heart Immunoglobulin Allotypes Immunoglobulin G Ligands Major Histocompatibility Complex Mice Mice, Inbred BALB C Mice, Inbred C3H Muscle, Smooth Myocardium Practolol Propranolol Receptors, Adrenergic, beta Tritium Reciprocal interaction between β-adrenoceptor specific ligand occupancy and alloantibody binding to specific antigens of cardiac and smooth muscle tissues was observed. Interference of alloimmune antibody fixation to both cardiac and oviductal tract preparations by β1 or β2 selective blockers, respectively, was obtained by means of indirect immunofluorescence assays. Reciprocally, alloimmune IgG and monoclonal antibodies directed to class I H-2 antigens, behaving as β-adrenoceptor agonists, modified the contractility of both tissues, increasing intracellular levels of cyclic AMP (cAMP). Additionally, alloantibodies were also capable of inhibiting specific β-adrenoceptor radioligand binding to purified cardiac and smooth muscle membranes. These data suggested a modulation of β-adrenoceptor function by antibodies directed against H-2 class I histocompatibility molecules, probably through molecular interactions between both structures. © 1990. 1990 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062952_v39_n12_p1861_Cremaschi http://hdl.handle.net/20.500.12110/paper_00062952_v39_n12_p1861_Cremaschi
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	4 hydroxyoxprenolol beta adrenergic receptor butoxamine cyclic amp dihydroalprenolol immunoglobulin g monoclonal antibody practolol propranolol unclassified drug alloimmunization animal cell animal experiment article heart muscle immunofluorescence ligand binding major histocompatibility complex nonhuman priority journal smooth muscle uterine tube Animal Antibodies, Monoclonal Butoxamine Cyclic AMP Female Heart Immunoglobulin Allotypes Immunoglobulin G Ligands Major Histocompatibility Complex Mice Mice, Inbred BALB C Mice, Inbred C3H Muscle, Smooth Myocardium Practolol Propranolol Receptors, Adrenergic, beta Tritium
spellingShingle	4 hydroxyoxprenolol beta adrenergic receptor butoxamine cyclic amp dihydroalprenolol immunoglobulin g monoclonal antibody practolol propranolol unclassified drug alloimmunization animal cell animal experiment article heart muscle immunofluorescence ligand binding major histocompatibility complex nonhuman priority journal smooth muscle uterine tube Animal Antibodies, Monoclonal Butoxamine Cyclic AMP Female Heart Immunoglobulin Allotypes Immunoglobulin G Ligands Major Histocompatibility Complex Mice Mice, Inbred BALB C Mice, Inbred C3H Muscle, Smooth Myocardium Practolol Propranolol Receptors, Adrenergic, beta Tritium Major histocompatibility complex modulation of β-adrenoceptor function
topic_facet	4 hydroxyoxprenolol beta adrenergic receptor butoxamine cyclic amp dihydroalprenolol immunoglobulin g monoclonal antibody practolol propranolol unclassified drug alloimmunization animal cell animal experiment article heart muscle immunofluorescence ligand binding major histocompatibility complex nonhuman priority journal smooth muscle uterine tube Animal Antibodies, Monoclonal Butoxamine Cyclic AMP Female Heart Immunoglobulin Allotypes Immunoglobulin G Ligands Major Histocompatibility Complex Mice Mice, Inbred BALB C Mice, Inbred C3H Muscle, Smooth Myocardium Practolol Propranolol Receptors, Adrenergic, beta Tritium
description	Reciprocal interaction between β-adrenoceptor specific ligand occupancy and alloantibody binding to specific antigens of cardiac and smooth muscle tissues was observed. Interference of alloimmune antibody fixation to both cardiac and oviductal tract preparations by β1 or β2 selective blockers, respectively, was obtained by means of indirect immunofluorescence assays. Reciprocally, alloimmune IgG and monoclonal antibodies directed to class I H-2 antigens, behaving as β-adrenoceptor agonists, modified the contractility of both tissues, increasing intracellular levels of cyclic AMP (cAMP). Additionally, alloantibodies were also capable of inhibiting specific β-adrenoceptor radioligand binding to purified cardiac and smooth muscle membranes. These data suggested a modulation of β-adrenoceptor function by antibodies directed against H-2 class I histocompatibility molecules, probably through molecular interactions between both structures. © 1990.
title	Major histocompatibility complex modulation of β-adrenoceptor function
title_short	Major histocompatibility complex modulation of β-adrenoceptor function
title_full	Major histocompatibility complex modulation of β-adrenoceptor function
title_fullStr	Major histocompatibility complex modulation of β-adrenoceptor function
title_full_unstemmed	Major histocompatibility complex modulation of β-adrenoceptor function
title_sort	major histocompatibility complex modulation of β-adrenoceptor function
publishDate	1990
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00062952_v39_n12_p1861_Cremaschi http://hdl.handle.net/20.500.12110/paper_00062952_v39_n12_p1861_Cremaschi
_version_	1768542966044950528

Major histocompatibility complex modulation of β-adrenoceptor function

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