Stimulation of phosphoinositide hydrolysis via class I antigen-specific recognition in murine cardiac tissue
Induction of polyphosphoinositide hydrolysis in cardiac tissue by specific recognition of class I histocompatibility antigens was assayed. C3H (H-2k) mice auricles were labelled with myo-3H]inositol precursor and inositol phosphate production in the presence or absence of anti-class I k products was...
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1989
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v249_n2_p302_Cremaschi http://hdl.handle.net/20.500.12110/paper_00145793_v249_n2_p302_Cremaschi |
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paper:paper_00145793_v249_n2_p302_Cremaschi |
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paper:paper_00145793_v249_n2_p302_Cremaschi2023-06-08T14:37:33Z Stimulation of phosphoinositide hydrolysis via class I antigen-specific recognition in murine cardiac tissue Adrenergic receptor, α- Alloantibody Histocompatibility antigen Muscarinic cholinergic receptor Phosphoinositide turnover Phospholipase C adrenergic receptor alloantibody muscarinic receptor phosphatidylinositide phospholipase c radioisotope animal cell histocompatibility mouse nonhuman priority journal Animal Heart Atrium Histocompatibility Antigens Class I Hydrolysis Immunoglobulin G In Vitro Isoantibodies Mice Mice, Inbred C3H Myocardium Phosphatidylinositols Receptors, Adrenergic, alpha Receptors, Cholinergic Support, Non-U.S. Gov't Induction of polyphosphoinositide hydrolysis in cardiac tissue by specific recognition of class I histocompatibility antigens was assayed. C3H (H-2k) mice auricles were labelled with myo-3H]inositol precursor and inositol phosphate production in the presence or absence of anti-class I k products was measured. Anti-class I, but not anti-class II products specifically increased phosphoinositide turnover. This increment was partially blocked by muscarinic cholinergic and α-adrenergic blockers and even more so by the phospholipase C inhibitor NCDC. Alloantibodies specifically directed against class I antigens could then exert stimulation of phospholipase C-mediated phosphoinositide hydrolysis through the interaction with muscarinic cholinergic and/or α-adrenergic receptors. The induction of intracellular second messengers by class I antigens and hormone-receptor interactions is discussed. © 1989. 1989 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v249_n2_p302_Cremaschi http://hdl.handle.net/20.500.12110/paper_00145793_v249_n2_p302_Cremaschi |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Adrenergic receptor, α- Alloantibody Histocompatibility antigen Muscarinic cholinergic receptor Phosphoinositide turnover Phospholipase C adrenergic receptor alloantibody muscarinic receptor phosphatidylinositide phospholipase c radioisotope animal cell histocompatibility mouse nonhuman priority journal Animal Heart Atrium Histocompatibility Antigens Class I Hydrolysis Immunoglobulin G In Vitro Isoantibodies Mice Mice, Inbred C3H Myocardium Phosphatidylinositols Receptors, Adrenergic, alpha Receptors, Cholinergic Support, Non-U.S. Gov't |
| spellingShingle |
Adrenergic receptor, α- Alloantibody Histocompatibility antigen Muscarinic cholinergic receptor Phosphoinositide turnover Phospholipase C adrenergic receptor alloantibody muscarinic receptor phosphatidylinositide phospholipase c radioisotope animal cell histocompatibility mouse nonhuman priority journal Animal Heart Atrium Histocompatibility Antigens Class I Hydrolysis Immunoglobulin G In Vitro Isoantibodies Mice Mice, Inbred C3H Myocardium Phosphatidylinositols Receptors, Adrenergic, alpha Receptors, Cholinergic Support, Non-U.S. Gov't Stimulation of phosphoinositide hydrolysis via class I antigen-specific recognition in murine cardiac tissue |
| topic_facet |
Adrenergic receptor, α- Alloantibody Histocompatibility antigen Muscarinic cholinergic receptor Phosphoinositide turnover Phospholipase C adrenergic receptor alloantibody muscarinic receptor phosphatidylinositide phospholipase c radioisotope animal cell histocompatibility mouse nonhuman priority journal Animal Heart Atrium Histocompatibility Antigens Class I Hydrolysis Immunoglobulin G In Vitro Isoantibodies Mice Mice, Inbred C3H Myocardium Phosphatidylinositols Receptors, Adrenergic, alpha Receptors, Cholinergic Support, Non-U.S. Gov't |
| description |
Induction of polyphosphoinositide hydrolysis in cardiac tissue by specific recognition of class I histocompatibility antigens was assayed. C3H (H-2k) mice auricles were labelled with myo-3H]inositol precursor and inositol phosphate production in the presence or absence of anti-class I k products was measured. Anti-class I, but not anti-class II products specifically increased phosphoinositide turnover. This increment was partially blocked by muscarinic cholinergic and α-adrenergic blockers and even more so by the phospholipase C inhibitor NCDC. Alloantibodies specifically directed against class I antigens could then exert stimulation of phospholipase C-mediated phosphoinositide hydrolysis through the interaction with muscarinic cholinergic and/or α-adrenergic receptors. The induction of intracellular second messengers by class I antigens and hormone-receptor interactions is discussed. © 1989. |
| title |
Stimulation of phosphoinositide hydrolysis via class I antigen-specific recognition in murine cardiac tissue |
| title_short |
Stimulation of phosphoinositide hydrolysis via class I antigen-specific recognition in murine cardiac tissue |
| title_full |
Stimulation of phosphoinositide hydrolysis via class I antigen-specific recognition in murine cardiac tissue |
| title_fullStr |
Stimulation of phosphoinositide hydrolysis via class I antigen-specific recognition in murine cardiac tissue |
| title_full_unstemmed |
Stimulation of phosphoinositide hydrolysis via class I antigen-specific recognition in murine cardiac tissue |
| title_sort |
stimulation of phosphoinositide hydrolysis via class i antigen-specific recognition in murine cardiac tissue |
| publishDate |
1989 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00145793_v249_n2_p302_Cremaschi http://hdl.handle.net/20.500.12110/paper_00145793_v249_n2_p302_Cremaschi |
| _version_ |
1768543354993246208 |