Physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis
The effects of norepinephrine, phentolamine, oxytocin, vasopressin, several prostaglandins, and indomethacin on the spontaneous motility of isolated guinea pig cauda epididymidis were explored. Phentolamine and indomethacin reduced the isometric peak tension of spontaneous epididymal contractions. P...
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1975
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00150282_v26_n12_p1250_DaSilvaSouza http://hdl.handle.net/20.500.12110/paper_00150282_v26_n12_p1250_DaSilvaSouza |
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paper:paper_00150282_v26_n12_p1250_DaSilvaSouza2023-06-08T14:37:52Z Physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis indometacin noradrenalin oxytocin phentolamine phentolamine mesylate prostaglandin prostaglandin E1 prostaglandin E2 prostaglandin F2 alpha vasopressin epididymis guinea pig in vitro study smooth muscle contractility smooth muscle contraction theoretical study The effects of norepinephrine, phentolamine, oxytocin, vasopressin, several prostaglandins, and indomethacin on the spontaneous motility of isolated guinea pig cauda epididymidis were explored. Phentolamine and indomethacin reduced the isometric peak tension of spontaneous epididymal contractions. Phentolamine also depressed the frequency. Both findings suggest that catecholamines and endogenous prostaglandins are in some way regulators of the spontaneous motility of the cauda epididymidis. Norepinephrine resulted in the development of a distinct, sustained, tonic contraction without plastic activity, whereas prostaglandins E1, E2, and F(2α) elicited a tonic increase accompanied by frequent, superimposed, phasic contractions. Both oxytocin and vasopressin comparably enhanced epididymal motility, producing contractile responses similar to those observed with prostaglandins. Since the epididymal contractions can influence the time spent by spermatozoa in passing through the ductus epididymidis, the above mentioned compounds could play an important role in spermatozoal transport via modulation of epididymal contractile activity. In addition, such naturally occurring substances might regulate the release of sperm from the last portion of the epididymis into the ductus deferens. 1975 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00150282_v26_n12_p1250_DaSilvaSouza http://hdl.handle.net/20.500.12110/paper_00150282_v26_n12_p1250_DaSilvaSouza |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
indometacin noradrenalin oxytocin phentolamine phentolamine mesylate prostaglandin prostaglandin E1 prostaglandin E2 prostaglandin F2 alpha vasopressin epididymis guinea pig in vitro study smooth muscle contractility smooth muscle contraction theoretical study |
| spellingShingle |
indometacin noradrenalin oxytocin phentolamine phentolamine mesylate prostaglandin prostaglandin E1 prostaglandin E2 prostaglandin F2 alpha vasopressin epididymis guinea pig in vitro study smooth muscle contractility smooth muscle contraction theoretical study Physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis |
| topic_facet |
indometacin noradrenalin oxytocin phentolamine phentolamine mesylate prostaglandin prostaglandin E1 prostaglandin E2 prostaglandin F2 alpha vasopressin epididymis guinea pig in vitro study smooth muscle contractility smooth muscle contraction theoretical study |
| description |
The effects of norepinephrine, phentolamine, oxytocin, vasopressin, several prostaglandins, and indomethacin on the spontaneous motility of isolated guinea pig cauda epididymidis were explored. Phentolamine and indomethacin reduced the isometric peak tension of spontaneous epididymal contractions. Phentolamine also depressed the frequency. Both findings suggest that catecholamines and endogenous prostaglandins are in some way regulators of the spontaneous motility of the cauda epididymidis. Norepinephrine resulted in the development of a distinct, sustained, tonic contraction without plastic activity, whereas prostaglandins E1, E2, and F(2α) elicited a tonic increase accompanied by frequent, superimposed, phasic contractions. Both oxytocin and vasopressin comparably enhanced epididymal motility, producing contractile responses similar to those observed with prostaglandins. Since the epididymal contractions can influence the time spent by spermatozoa in passing through the ductus epididymidis, the above mentioned compounds could play an important role in spermatozoal transport via modulation of epididymal contractile activity. In addition, such naturally occurring substances might regulate the release of sperm from the last portion of the epididymis into the ductus deferens. |
| title |
Physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis |
| title_short |
Physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis |
| title_full |
Physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis |
| title_fullStr |
Physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis |
| title_full_unstemmed |
Physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis |
| title_sort |
physiologic and pharmacologic studies on the motility of isolated guinea pig cauda epididymidis |
| publishDate |
1975 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00150282_v26_n12_p1250_DaSilvaSouza http://hdl.handle.net/20.500.12110/paper_00150282_v26_n12_p1250_DaSilvaSouza |
| _version_ |
1768543495767719936 |