Microwave-Assisted Synthesis of Pyrrolo[2,1-b]thiazoles Linked to a Carbohydrate Moiety
Herein, we describe the synthesis of pyrrolo[2,1-b]thiazoles substituted on C-2 or C-5 with a protected carbohydrate moiety. The new fused bicyclic heterocycles were obtained via thiazole intermediates, and the N-alkylation step was assisted by microwave irradiation. The new products were completely...
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| Autores principales: | , , , , |
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| Publicado: |
2013
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0022152X_v_n_p_Barradas http://hdl.handle.net/20.500.12110/paper_0022152X_v_n_p_Barradas |
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| Sumario: | Herein, we describe the synthesis of pyrrolo[2,1-b]thiazoles substituted on C-2 or C-5 with a protected carbohydrate moiety. The new fused bicyclic heterocycles were obtained via thiazole intermediates, and the N-alkylation step was assisted by microwave irradiation. The new products were completely characterized by physical and spectroscopic techniques. The cytotoxicity and antiviral activity against Junín virus of the methylated derivates was also evaluated. © 2013 HeteroCorporation. |
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