Long Wavelength Phototriggering: Ruthenium-Based Caged Compounds

Here we describe the use of Ru polypyridine compounds as caging agents for a variety of molecules. The photorelease of the caged molecule can be triggered using visible light (450-500 nm) with a high quantum yield. These caged compounds are very stable in aqueous environments and yield the molecule...

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Autores principales:	Filevich, Oscar, Zayat, Leonardo Martin, Baraldo Victorica, Luis Mario, Etchenique, Roberto
Publicado:	2015
Materias:	Caged compounds Photoremovable protecting group Photosensitization Ruthenium polypyridines Two-photon absorption
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00815993_v165_n_p47_Filevich http://hdl.handle.net/20.500.12110/paper_00815993_v165_n_p47_Filevich
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00815993_v165_n_p47_Filevich
record_format	dspace
spelling	paper:paper_00815993_v165_n_p47_Filevich2023-06-08T15:07:38Z Long Wavelength Phototriggering: Ruthenium-Based Caged Compounds Filevich, Oscar Zayat, Leonardo Martin Baraldo Victorica, Luis Mario Etchenique, Roberto Caged compounds Photoremovable protecting group Photosensitization Ruthenium polypyridines Two-photon absorption Here we describe the use of Ru polypyridine compounds as caging agents for a variety of molecules. The photorelease of the caged molecule can be triggered using visible light (450-500 nm) with a high quantum yield. These caged compounds are very stable in aqueous environments and yield the molecule of interest intact in a single step without secondary reactions. The affinity of the Ru polypyridine for amine groups allows the caging of a variety of molecules, including neurochemicals and neurotransmitters like 4-aminopyridine, glutamate, gamma aminobutyric acid, glycine, serotonin, dopamine, and nicotine. These caged molecules have been used to elicit the response of neurons, both in vitro and in vivo experiments. Besides neurotransmitters other types of molecules, like antiproliferative drugs, can also be caged. In addition, sulfur-containing molecules, such as methylthiogalactose, can also be caged by this fragment. Another interesting application of the Ru polypyridine fragment is the caging of fluorescent dyes which can be uncaged using visible light. All of these applications can also be implemented using infrared light, as one of the distinctive advantages of Ru polypyridines as caging agents is their ability to be triggered in a two-photon regime, allowing the use of high power IR pulses to uncage the desired molecule. © 2015 Springer-Verlag Berlin Heidelberg. Fil:Filevich, O. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Zayat, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Baraldo, L.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Etchenique, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00815993_v165_n_p47_Filevich http://hdl.handle.net/20.500.12110/paper_00815993_v165_n_p47_Filevich
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Caged compounds Photoremovable protecting group Photosensitization Ruthenium polypyridines Two-photon absorption
spellingShingle	Caged compounds Photoremovable protecting group Photosensitization Ruthenium polypyridines Two-photon absorption Filevich, Oscar Zayat, Leonardo Martin Baraldo Victorica, Luis Mario Etchenique, Roberto Long Wavelength Phototriggering: Ruthenium-Based Caged Compounds
topic_facet	Caged compounds Photoremovable protecting group Photosensitization Ruthenium polypyridines Two-photon absorption
description	Here we describe the use of Ru polypyridine compounds as caging agents for a variety of molecules. The photorelease of the caged molecule can be triggered using visible light (450-500 nm) with a high quantum yield. These caged compounds are very stable in aqueous environments and yield the molecule of interest intact in a single step without secondary reactions. The affinity of the Ru polypyridine for amine groups allows the caging of a variety of molecules, including neurochemicals and neurotransmitters like 4-aminopyridine, glutamate, gamma aminobutyric acid, glycine, serotonin, dopamine, and nicotine. These caged molecules have been used to elicit the response of neurons, both in vitro and in vivo experiments. Besides neurotransmitters other types of molecules, like antiproliferative drugs, can also be caged. In addition, sulfur-containing molecules, such as methylthiogalactose, can also be caged by this fragment. Another interesting application of the Ru polypyridine fragment is the caging of fluorescent dyes which can be uncaged using visible light. All of these applications can also be implemented using infrared light, as one of the distinctive advantages of Ru polypyridines as caging agents is their ability to be triggered in a two-photon regime, allowing the use of high power IR pulses to uncage the desired molecule. © 2015 Springer-Verlag Berlin Heidelberg.
author	Filevich, Oscar Zayat, Leonardo Martin Baraldo Victorica, Luis Mario Etchenique, Roberto
author_facet	Filevich, Oscar Zayat, Leonardo Martin Baraldo Victorica, Luis Mario Etchenique, Roberto
author_sort	Filevich, Oscar
title	Long Wavelength Phototriggering: Ruthenium-Based Caged Compounds
title_short	Long Wavelength Phototriggering: Ruthenium-Based Caged Compounds
title_full	Long Wavelength Phototriggering: Ruthenium-Based Caged Compounds
title_fullStr	Long Wavelength Phototriggering: Ruthenium-Based Caged Compounds
title_full_unstemmed	Long Wavelength Phototriggering: Ruthenium-Based Caged Compounds
title_sort	long wavelength phototriggering: ruthenium-based caged compounds
publishDate	2015
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00815993_v165_n_p47_Filevich http://hdl.handle.net/20.500.12110/paper_00815993_v165_n_p47_Filevich
work_keys_str_mv	AT filevichoscar longwavelengthphototriggeringrutheniumbasedcagedcompounds AT zayatleonardomartin longwavelengthphototriggeringrutheniumbasedcagedcompounds AT baraldovictoricaluismario longwavelengthphototriggeringrutheniumbasedcagedcompounds AT etcheniqueroberto longwavelengthphototriggeringrutheniumbasedcagedcompounds
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Long Wavelength Phototriggering: Ruthenium-Based Caged Compounds

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