Leptin promotes HLA-G expression on placental trophoblasts via the MEK/Erk and PI3K signaling pathways

Introduction The development of the human haemochorial placenta requires complex regulatory mechanisms to protect invasive trophoblast cells from cytotoxic responses elicited by maternal immune cells. Leptin, the adipocyte derived hormone encoded by the Lep gene, is synthesized by placental trophobl...

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Detalles Bibliográficos
Autor principal:	Varone, Cecilia Laura
Publicado:	2015
Materias:	HLA-G Leptin Placenta Signal transduction 2 (2 amino 3 methoxyphenyl)chromone 2 morpholino 8 phenylchromone HLA G antigen leptin mitogen activated protein kinase kinase phosphatidylinositol 3 kinase protein kinase B recombinant leptin antisense oligodeoxynucleotide protein kinase inhibitor recombinant protein antigen expression Article choriocarcinoma cell line controlled study embryo explant female first trimester pregnancy gene expression hormone action human human cell immune evasion immune response immunofluorescence immunomodulation in vitro study placenta priority journal protein expression reverse transcription polymerase chain reaction signal transduction syncytiotrophoblast trophoblast upregulation Western blotting adult antagonists and inhibitors cell line chemistry cytology drug effects gene expression regulation gene silencing genetics immunology metabolism pregnancy reproduction third trimester pregnancy tissue culture technique Adult Cell Line Female Gene Expression Regulation, Developmental Gene Silencing HLA-G Antigens Humans MAP Kinase Signaling System Oligodeoxyribonucleotides, Antisense Phosphatidylinositol 3-Kinase Placentation Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Third Protein Kinase Inhibitors Recombinant Proteins Signal Transduction Tissue Culture Techniques Trophoblasts
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_01434004_v36_n4_p419_Barrientos http://hdl.handle.net/20.500.12110/paper_01434004_v36_n4_p419_Barrientos
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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