Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties

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Fused heterobicyclic systems have gained much importance in the field of medicinal chemistry because of their broad spectrum of physiological activities. Among the heterocyclic rings containing bridgehead nitrogen atom, imidazothiazoles derivatives are especially attractive because of their differen...

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Autores principales:	Fascio, Mirta Liliana, Errea, María Inés, D'Accorso, Norma Beatriz
Publicado:	2015
Materias:	Biological activities Imidazo[2 1-b]thiazoles Imidazo[2 1-b][1 3 4]thiadiazoles Imidazo[2 1-c][1 2 4]triazoles Pyrrolo[2 1-b]thiazoles alprazolam ampicillin anastrozole antineoplastic agent bleomycin estazolam etoperidone fluconazole heterocyclic compound imidazole derivative itraconazole letrozole nefazodone new drug pyrrole derivative ribavirin rilmazafone terconazole thiazole derivative trapidil trazodone vorozole antiinfective agent antivirus agent antibacterial activity antifungal activity antineoplastic activity antioxidant activity antiproliferative activity Article biological activity cancer cell line catalyst chronotropism cyclization deacetylation drug binding site drug synthesis enzyme activity heating human hydrogen bond hydrolysis inotropism isomerization microwave radiation minimum inhibitory concentration molecular docking nonhuman oxidation reaction time therapy effect animal cell proliferation chemistry drug effects synthesis Animals Anti-Bacterial Agents Antineoplastic Agents Antiviral Agents Cell Proliferation Heterocyclic Compounds Humans Imidazoles Thiazoles
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02235234_v90_n_p666_Fascio http://hdl.handle.net/20.500.12110/paper_02235234_v90_n_p666_Fascio
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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spelling	paper:paper_02235234_v90_n_p666_Fascio2023-06-08T15:21:47Z Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties Fascio, Mirta Liliana Errea, María Inés D'Accorso, Norma Beatriz Biological activities Imidazo[2 1-b]thiazoles Imidazo[2 1-b][1 3 4]thiadiazoles Imidazo[2 1-c][1 2 4]triazoles Pyrrolo[2 1-b]thiazoles alprazolam ampicillin anastrozole antineoplastic agent bleomycin estazolam etoperidone fluconazole heterocyclic compound imidazole derivative itraconazole letrozole nefazodone new drug pyrrole derivative ribavirin rilmazafone terconazole thiazole derivative trapidil trazodone vorozole antiinfective agent antineoplastic agent antivirus agent heterocyclic compound imidazole derivative thiazole derivative antibacterial activity antifungal activity antineoplastic activity antioxidant activity antiproliferative activity Article biological activity cancer cell line catalyst chronotropism cyclization deacetylation drug binding site drug synthesis enzyme activity heating human hydrogen bond hydrolysis inotropism isomerization microwave radiation minimum inhibitory concentration molecular docking nonhuman oxidation reaction time therapy effect animal cell proliferation chemistry drug effects synthesis Animals Anti-Bacterial Agents Antineoplastic Agents Antiviral Agents Cell Proliferation Heterocyclic Compounds Humans Imidazoles Thiazoles Fused heterobicyclic systems have gained much importance in the field of medicinal chemistry because of their broad spectrum of physiological activities. Among the heterocyclic rings containing bridgehead nitrogen atom, imidazothiazoles derivatives are especially attractive because of their different biological activities.Since many imidazothiazoles derivatives are effective for treating several diseases, is interesting to analyze the behavior of some isosteric related heterocycles, such as pirrolothiazoles, imidazothiadiazoles and imidazotriazoles. In this context, this review summarizes the current knowledge about the syntheses and biological behavior of these families of heterocycles. Traditional synthetic methodologies as well as alternative synthetic procedures are described. Among these last methodologies, the use of multicomponent reaction, novel and efficient coupling reagents, and environmental friendly strategies, like microwave assistance and solvent-free condition in ionic liquids are also summarized. This review includes the biological assessments, docking research and studies of mechanism of action performed in order to obtain the compounds leading to the development of new drugs. © 2014 Published by Elsevier Masson SAS. Fil:Fascio, M.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Errea, M.I. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:D'Accorso, N.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02235234_v90_n_p666_Fascio http://hdl.handle.net/20.500.12110/paper_02235234_v90_n_p666_Fascio
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Biological activities Imidazo[2 1-b]thiazoles Imidazo[2 1-b][1 3 4]thiadiazoles Imidazo[2 1-c][1 2 4]triazoles Pyrrolo[2 1-b]thiazoles alprazolam ampicillin anastrozole antineoplastic agent bleomycin estazolam etoperidone fluconazole heterocyclic compound imidazole derivative itraconazole letrozole nefazodone new drug pyrrole derivative ribavirin rilmazafone terconazole thiazole derivative trapidil trazodone vorozole antiinfective agent antineoplastic agent antivirus agent heterocyclic compound imidazole derivative thiazole derivative antibacterial activity antifungal activity antineoplastic activity antioxidant activity antiproliferative activity Article biological activity cancer cell line catalyst chronotropism cyclization deacetylation drug binding site drug synthesis enzyme activity heating human hydrogen bond hydrolysis inotropism isomerization microwave radiation minimum inhibitory concentration molecular docking nonhuman oxidation reaction time therapy effect animal cell proliferation chemistry drug effects synthesis Animals Anti-Bacterial Agents Antineoplastic Agents Antiviral Agents Cell Proliferation Heterocyclic Compounds Humans Imidazoles Thiazoles
spellingShingle	Biological activities Imidazo[2 1-b]thiazoles Imidazo[2 1-b][1 3 4]thiadiazoles Imidazo[2 1-c][1 2 4]triazoles Pyrrolo[2 1-b]thiazoles alprazolam ampicillin anastrozole antineoplastic agent bleomycin estazolam etoperidone fluconazole heterocyclic compound imidazole derivative itraconazole letrozole nefazodone new drug pyrrole derivative ribavirin rilmazafone terconazole thiazole derivative trapidil trazodone vorozole antiinfective agent antineoplastic agent antivirus agent heterocyclic compound imidazole derivative thiazole derivative antibacterial activity antifungal activity antineoplastic activity antioxidant activity antiproliferative activity Article biological activity cancer cell line catalyst chronotropism cyclization deacetylation drug binding site drug synthesis enzyme activity heating human hydrogen bond hydrolysis inotropism isomerization microwave radiation minimum inhibitory concentration molecular docking nonhuman oxidation reaction time therapy effect animal cell proliferation chemistry drug effects synthesis Animals Anti-Bacterial Agents Antineoplastic Agents Antiviral Agents Cell Proliferation Heterocyclic Compounds Humans Imidazoles Thiazoles Fascio, Mirta Liliana Errea, María Inés D'Accorso, Norma Beatriz Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties
topic_facet	Biological activities Imidazo[2 1-b]thiazoles Imidazo[2 1-b][1 3 4]thiadiazoles Imidazo[2 1-c][1 2 4]triazoles Pyrrolo[2 1-b]thiazoles alprazolam ampicillin anastrozole antineoplastic agent bleomycin estazolam etoperidone fluconazole heterocyclic compound imidazole derivative itraconazole letrozole nefazodone new drug pyrrole derivative ribavirin rilmazafone terconazole thiazole derivative trapidil trazodone vorozole antiinfective agent antineoplastic agent antivirus agent heterocyclic compound imidazole derivative thiazole derivative antibacterial activity antifungal activity antineoplastic activity antioxidant activity antiproliferative activity Article biological activity cancer cell line catalyst chronotropism cyclization deacetylation drug binding site drug synthesis enzyme activity heating human hydrogen bond hydrolysis inotropism isomerization microwave radiation minimum inhibitory concentration molecular docking nonhuman oxidation reaction time therapy effect animal cell proliferation chemistry drug effects synthesis Animals Anti-Bacterial Agents Antineoplastic Agents Antiviral Agents Cell Proliferation Heterocyclic Compounds Humans Imidazoles Thiazoles
description	Fused heterobicyclic systems have gained much importance in the field of medicinal chemistry because of their broad spectrum of physiological activities. Among the heterocyclic rings containing bridgehead nitrogen atom, imidazothiazoles derivatives are especially attractive because of their different biological activities.Since many imidazothiazoles derivatives are effective for treating several diseases, is interesting to analyze the behavior of some isosteric related heterocycles, such as pirrolothiazoles, imidazothiadiazoles and imidazotriazoles. In this context, this review summarizes the current knowledge about the syntheses and biological behavior of these families of heterocycles. Traditional synthetic methodologies as well as alternative synthetic procedures are described. Among these last methodologies, the use of multicomponent reaction, novel and efficient coupling reagents, and environmental friendly strategies, like microwave assistance and solvent-free condition in ionic liquids are also summarized. This review includes the biological assessments, docking research and studies of mechanism of action performed in order to obtain the compounds leading to the development of new drugs. © 2014 Published by Elsevier Masson SAS.
author	Fascio, Mirta Liliana Errea, María Inés D'Accorso, Norma Beatriz
author_facet	Fascio, Mirta Liliana Errea, María Inés D'Accorso, Norma Beatriz
author_sort	Fascio, Mirta Liliana
title	Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties
title_short	Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties
title_full	Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties
title_fullStr	Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties
title_full_unstemmed	Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties
title_sort	imidazothiazole and related heterocyclic systems. synthesis, chemical and biological properties
publishDate	2015
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_02235234_v90_n_p666_Fascio http://hdl.handle.net/20.500.12110/paper_02235234_v90_n_p666_Fascio
work_keys_str_mv	AT fasciomirtaliliana imidazothiazoleandrelatedheterocyclicsystemssynthesischemicalandbiologicalproperties AT erreamariaines imidazothiazoleandrelatedheterocyclicsystemssynthesischemicalandbiologicalproperties AT daccorsonormabeatriz imidazothiazoleandrelatedheterocyclicsystemssynthesischemicalandbiologicalproperties
_version_	1768546112338132992

Imidazothiazole and related heterocyclic systems. Synthesis, chemical and biological properties

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