Altered heme pathway regulation and drug metabolizing enzyme system in a mouse model of hepatocarcinogenesis: Effect of veronal
1. Male CF 1 mice were fed p-dimethylaminoazobenzene (DAB) for 35 days and received 5,5 diethylbarbituric acid, before or after DAB treatment, with the purpose of investigating whether the onset of the preinitiation stage of carcinogenesis alters the natural regulatory mechanism of the heme pathway....
Guardado en:
| Autores principales: | , , |
|---|---|
| Publicado: |
1997
|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v29_n4_p569_Gerez http://hdl.handle.net/20.500.12110/paper_03063623_v29_n4_p569_Gerez |
| Aporte de: |
| id |
paper:paper_03063623_v29_n4_p569_Gerez |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_03063623_v29_n4_p569_Gerez2023-06-08T15:31:08Z Altered heme pathway regulation and drug metabolizing enzyme system in a mouse model of hepatocarcinogenesis: Effect of veronal Gerez, Esther Noemí Vázquez, Elba Susana Batlle, Alcira María del Carmen Azo-dye Drug metabolizing enzyme system Heme metabolism Hepatocarcinogenesis Porphyrinogen drug 4 dimethylaminoazobenzene 5 aminolevulinate synthase barbital cytochrome p450 heme oxygenase animal model animal tissue article controlled study enzyme activity heme synthesis liver carcinogenesis male mouse nonhuman priority journal 1. Male CF 1 mice were fed p-dimethylaminoazobenzene (DAB) for 35 days and received 5,5 diethylbarbituric acid, before or after DAB treatment, with the purpose of investigating whether the onset of the preinitiation stage of carcinogenesis alters the natural regulatory mechanism of the heme pathway. 2. Changes detected in drug metabolizing enzymes are likely to be the consequence of a primary deregulation mechanism of heme metabolism, shown by an increase in 6 aminolevulinic acid synthetase activity and a decrease in microsomal heme oxygenase, which would finally lead to a great enhancement of cytochrome P450 levels. 3. The alterations found here would give rise to a pattern distinctive to that usually observed in the so called resistant hepatocyte. Fil:Gerez, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Vazquez, E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Batlle, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1997 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v29_n4_p569_Gerez http://hdl.handle.net/20.500.12110/paper_03063623_v29_n4_p569_Gerez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Azo-dye Drug metabolizing enzyme system Heme metabolism Hepatocarcinogenesis Porphyrinogen drug 4 dimethylaminoazobenzene 5 aminolevulinate synthase barbital cytochrome p450 heme oxygenase animal model animal tissue article controlled study enzyme activity heme synthesis liver carcinogenesis male mouse nonhuman priority journal |
| spellingShingle |
Azo-dye Drug metabolizing enzyme system Heme metabolism Hepatocarcinogenesis Porphyrinogen drug 4 dimethylaminoazobenzene 5 aminolevulinate synthase barbital cytochrome p450 heme oxygenase animal model animal tissue article controlled study enzyme activity heme synthesis liver carcinogenesis male mouse nonhuman priority journal Gerez, Esther Noemí Vázquez, Elba Susana Batlle, Alcira María del Carmen Altered heme pathway regulation and drug metabolizing enzyme system in a mouse model of hepatocarcinogenesis: Effect of veronal |
| topic_facet |
Azo-dye Drug metabolizing enzyme system Heme metabolism Hepatocarcinogenesis Porphyrinogen drug 4 dimethylaminoazobenzene 5 aminolevulinate synthase barbital cytochrome p450 heme oxygenase animal model animal tissue article controlled study enzyme activity heme synthesis liver carcinogenesis male mouse nonhuman priority journal |
| description |
1. Male CF 1 mice were fed p-dimethylaminoazobenzene (DAB) for 35 days and received 5,5 diethylbarbituric acid, before or after DAB treatment, with the purpose of investigating whether the onset of the preinitiation stage of carcinogenesis alters the natural regulatory mechanism of the heme pathway. 2. Changes detected in drug metabolizing enzymes are likely to be the consequence of a primary deregulation mechanism of heme metabolism, shown by an increase in 6 aminolevulinic acid synthetase activity and a decrease in microsomal heme oxygenase, which would finally lead to a great enhancement of cytochrome P450 levels. 3. The alterations found here would give rise to a pattern distinctive to that usually observed in the so called resistant hepatocyte. |
| author |
Gerez, Esther Noemí Vázquez, Elba Susana Batlle, Alcira María del Carmen |
| author_facet |
Gerez, Esther Noemí Vázquez, Elba Susana Batlle, Alcira María del Carmen |
| author_sort |
Gerez, Esther Noemí |
| title |
Altered heme pathway regulation and drug metabolizing enzyme system in a mouse model of hepatocarcinogenesis: Effect of veronal |
| title_short |
Altered heme pathway regulation and drug metabolizing enzyme system in a mouse model of hepatocarcinogenesis: Effect of veronal |
| title_full |
Altered heme pathway regulation and drug metabolizing enzyme system in a mouse model of hepatocarcinogenesis: Effect of veronal |
| title_fullStr |
Altered heme pathway regulation and drug metabolizing enzyme system in a mouse model of hepatocarcinogenesis: Effect of veronal |
| title_full_unstemmed |
Altered heme pathway regulation and drug metabolizing enzyme system in a mouse model of hepatocarcinogenesis: Effect of veronal |
| title_sort |
altered heme pathway regulation and drug metabolizing enzyme system in a mouse model of hepatocarcinogenesis: effect of veronal |
| publishDate |
1997 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03063623_v29_n4_p569_Gerez http://hdl.handle.net/20.500.12110/paper_03063623_v29_n4_p569_Gerez |
| work_keys_str_mv |
AT gerezesthernoemi alteredhemepathwayregulationanddrugmetabolizingenzymesysteminamousemodelofhepatocarcinogenesiseffectofveronal AT vazquezelbasusana alteredhemepathwayregulationanddrugmetabolizingenzymesysteminamousemodelofhepatocarcinogenesiseffectofveronal AT batllealciramariadelcarmen alteredhemepathwayregulationanddrugmetabolizingenzymesysteminamousemodelofhepatocarcinogenesiseffectofveronal |
| _version_ |
1768543994203078656 |