Technetium‐99m‐dimethylglyoxime (99mTc‐DMG) as renal imaging agent

Dimethylglyoxime (DMG) labelled with 99mTc is here presented as a renal imaging agent. The behaviour of this complex was analysed at different pH by means of UV spectral data and using DMG‐calcium chloride as a reference complex. Biokinetic data were evaluated in two biological models, Sprague‐Dawle...

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Autores principales:	Cañellas, Carlos Oscar, Pomilio, Alicia Beatriz, Vitale, Arturo Alberto
Publicado:	1993
Materias:	Dimethylglyoxime Kidneys Technetium dimethylglyoxime technetium 99m animal model article controlled study isotope labeling kidney scintiscanning opossum rat Animalia Argentina (fish) Didelphidae Didelphis albiventris
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03624803_v33_n6_p443_Adonaylo http://hdl.handle.net/20.500.12110/paper_03624803_v33_n6_p443_Adonaylo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03624803_v33_n6_p443_Adonaylo
record_format	dspace
spelling	paper:paper_03624803_v33_n6_p443_Adonaylo2023-06-08T15:35:10Z Technetium‐99m‐dimethylglyoxime (99mTc‐DMG) as renal imaging agent Cañellas, Carlos Oscar Pomilio, Alicia Beatriz Vitale, Arturo Alberto Dimethylglyoxime Kidneys Technetium dimethylglyoxime technetium 99m animal model article controlled study isotope labeling kidney scintiscanning opossum rat Animalia Argentina (fish) Didelphidae Didelphis albiventris Dimethylglyoxime (DMG) labelled with 99mTc is here presented as a renal imaging agent. The behaviour of this complex was analysed at different pH by means of UV spectral data and using DMG‐calcium chloride as a reference complex. Biokinetic data were evaluated in two biological models, Sprague‐Dawley rats and Didelphis albiventris argentine opossum. Biodistribution in rats demonstrated fast and specific renal excretion. Time‐activity vabues over both kidneys could be quantified for this complex. Renographic studies led to mean time‐to maximum values on twelve assays of 2.0 ± 0.1 min and a mean relative function of 53.0 ± 2.3 and 47.0 ± 3.2 for right and left kidneys, respectively. 99mTc‐DMG showed specificity for the renal excretion pathway and therefore Seems to be a very useful radiopharmaceutical for renal function studies. Copyright © 1993 John Wiley & Sons, Ltd. Fil:Cañellas, C.O. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pomilio, A.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Vitale, A.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1993 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03624803_v33_n6_p443_Adonaylo http://hdl.handle.net/20.500.12110/paper_03624803_v33_n6_p443_Adonaylo
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Dimethylglyoxime Kidneys Technetium dimethylglyoxime technetium 99m animal model article controlled study isotope labeling kidney scintiscanning opossum rat Animalia Argentina (fish) Didelphidae Didelphis albiventris
spellingShingle	Dimethylglyoxime Kidneys Technetium dimethylglyoxime technetium 99m animal model article controlled study isotope labeling kidney scintiscanning opossum rat Animalia Argentina (fish) Didelphidae Didelphis albiventris Cañellas, Carlos Oscar Pomilio, Alicia Beatriz Vitale, Arturo Alberto Technetium‐99m‐dimethylglyoxime (99mTc‐DMG) as renal imaging agent
topic_facet	Dimethylglyoxime Kidneys Technetium dimethylglyoxime technetium 99m animal model article controlled study isotope labeling kidney scintiscanning opossum rat Animalia Argentina (fish) Didelphidae Didelphis albiventris
description	Dimethylglyoxime (DMG) labelled with 99mTc is here presented as a renal imaging agent. The behaviour of this complex was analysed at different pH by means of UV spectral data and using DMG‐calcium chloride as a reference complex. Biokinetic data were evaluated in two biological models, Sprague‐Dawley rats and Didelphis albiventris argentine opossum. Biodistribution in rats demonstrated fast and specific renal excretion. Time‐activity vabues over both kidneys could be quantified for this complex. Renographic studies led to mean time‐to maximum values on twelve assays of 2.0 ± 0.1 min and a mean relative function of 53.0 ± 2.3 and 47.0 ± 3.2 for right and left kidneys, respectively. 99mTc‐DMG showed specificity for the renal excretion pathway and therefore Seems to be a very useful radiopharmaceutical for renal function studies. Copyright © 1993 John Wiley & Sons, Ltd.
author	Cañellas, Carlos Oscar Pomilio, Alicia Beatriz Vitale, Arturo Alberto
author_facet	Cañellas, Carlos Oscar Pomilio, Alicia Beatriz Vitale, Arturo Alberto
author_sort	Cañellas, Carlos Oscar
title	Technetium‐99m‐dimethylglyoxime (99mTc‐DMG) as renal imaging agent
title_short	Technetium‐99m‐dimethylglyoxime (99mTc‐DMG) as renal imaging agent
title_full	Technetium‐99m‐dimethylglyoxime (99mTc‐DMG) as renal imaging agent
title_fullStr	Technetium‐99m‐dimethylglyoxime (99mTc‐DMG) as renal imaging agent
title_full_unstemmed	Technetium‐99m‐dimethylglyoxime (99mTc‐DMG) as renal imaging agent
title_sort	technetium‐99m‐dimethylglyoxime (99mtc‐dmg) as renal imaging agent
publishDate	1993
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03624803_v33_n6_p443_Adonaylo http://hdl.handle.net/20.500.12110/paper_03624803_v33_n6_p443_Adonaylo
work_keys_str_mv	AT canellascarlososcar technetium99mdimethylglyoxime99mtcdmgasrenalimagingagent AT pomilioaliciabeatriz technetium99mdimethylglyoxime99mtcdmgasrenalimagingagent AT vitalearturoalberto technetium99mdimethylglyoxime99mtcdmgasrenalimagingagent
_version_	1768543518211440640

Technetium‐99m‐dimethylglyoxime (99mTc‐DMG) as renal imaging agent

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