Alkaloids of Datura ferox from Argentina

Chromatographic procedures (HPLC, GC-MS) are outlined in this paper for the analysis of alkaloids in poisonous Datura ferox seeds of Argentina, from which previously only quantitative analysis for scopolamine was known. Five additional tropane alkaloids are now identified as 3α-tigloyloxytropane (ti...

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Autores principales:	Vitale, Arturo Alberto, Acher, Andrés, Pomilio, Alicia Beatriz
Publicado:	1995
Materias:	3-Phenylacetoxy-6β,7β-epoxytropane (3-phenylacetoxyscopine) 3α-Tigloyloxytropane (tigloyltropeine) 7β-Hydroxy-6β-isovaleroyloxy-3α-tigloyloxytropane 7β-Hydroxy-6β-propenyloxy-3α-tropoyloxytropane Aposcopolamine (apohyoscine) Datura ferox GC-MS HPLC Hygrine Scopolamine (hyoscine) Tropane alkaloids hyoscyamine nicotine plant extract scopolamine tropane alkaloid tropane derivative argentina article drug determination drug isolation drug structure drug toxicity gas chromatography high performance liquid chromatography mass spectrometry nonhuman plant seed Alkaloids Argentina Chromatography, High Pressure Liquid Humans Plant Extracts Seeds
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03788741_v49_n2_p81_Vitale http://hdl.handle.net/20.500.12110/paper_03788741_v49_n2_p81_Vitale
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_03788741_v49_n2_p81_Vitale
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spelling	paper:paper_03788741_v49_n2_p81_Vitale2023-06-08T15:40:32Z Alkaloids of Datura ferox from Argentina Vitale, Arturo Alberto Acher, Andrés Pomilio, Alicia Beatriz 3-Phenylacetoxy-6β,7β-epoxytropane (3-phenylacetoxyscopine) 3α-Tigloyloxytropane (tigloyltropeine) 7β-Hydroxy-6β-isovaleroyloxy-3α-tigloyloxytropane 7β-Hydroxy-6β-propenyloxy-3α-tropoyloxytropane Aposcopolamine (apohyoscine) Datura ferox GC-MS HPLC Hygrine Scopolamine (hyoscine) Tropane alkaloids hyoscyamine nicotine plant extract scopolamine tropane alkaloid tropane derivative argentina article drug determination drug isolation drug structure drug toxicity gas chromatography high performance liquid chromatography mass spectrometry nonhuman plant seed Alkaloids Argentina Chromatography, High Pressure Liquid Humans Plant Extracts Seeds Chromatographic procedures (HPLC, GC-MS) are outlined in this paper for the analysis of alkaloids in poisonous Datura ferox seeds of Argentina, from which previously only quantitative analysis for scopolamine was known. Five additional tropane alkaloids are now identified as 3α-tigloyloxytropane (tigloyltropeine), 3-phenylacetoxy-6β,7β-epoxytropane (3-phenylacetoxyscopine), aposcopolamine (apohyoscine), 7β-hydroxy-6β-propenyloxy-3α-tropoyloxytropane, traces of 7β-hydroxy-6β-isovaleroyloxy-3α-tigloyloxytropane and a pyrrolidine alkaloid, hygrine. Two new structures, 3-phenylacetoxy-6β,7β-epoxytropane (3-phenylacetoxyscopine) and 7β-hydroxy-6β-propenyloxy-3α-tropoyloxytropane, are proposed on the basis of their spectra. Hyoscyamine, nicotine and tropane N-oxides were not detected in all samples studied. © 1995. Fil:Vitale, A.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Acher, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Pomilio, A.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1995 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03788741_v49_n2_p81_Vitale http://hdl.handle.net/20.500.12110/paper_03788741_v49_n2_p81_Vitale
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	3-Phenylacetoxy-6β,7β-epoxytropane (3-phenylacetoxyscopine) 3α-Tigloyloxytropane (tigloyltropeine) 7β-Hydroxy-6β-isovaleroyloxy-3α-tigloyloxytropane 7β-Hydroxy-6β-propenyloxy-3α-tropoyloxytropane Aposcopolamine (apohyoscine) Datura ferox GC-MS HPLC Hygrine Scopolamine (hyoscine) Tropane alkaloids hyoscyamine nicotine plant extract scopolamine tropane alkaloid tropane derivative argentina article drug determination drug isolation drug structure drug toxicity gas chromatography high performance liquid chromatography mass spectrometry nonhuman plant seed Alkaloids Argentina Chromatography, High Pressure Liquid Humans Plant Extracts Seeds
spellingShingle	3-Phenylacetoxy-6β,7β-epoxytropane (3-phenylacetoxyscopine) 3α-Tigloyloxytropane (tigloyltropeine) 7β-Hydroxy-6β-isovaleroyloxy-3α-tigloyloxytropane 7β-Hydroxy-6β-propenyloxy-3α-tropoyloxytropane Aposcopolamine (apohyoscine) Datura ferox GC-MS HPLC Hygrine Scopolamine (hyoscine) Tropane alkaloids hyoscyamine nicotine plant extract scopolamine tropane alkaloid tropane derivative argentina article drug determination drug isolation drug structure drug toxicity gas chromatography high performance liquid chromatography mass spectrometry nonhuman plant seed Alkaloids Argentina Chromatography, High Pressure Liquid Humans Plant Extracts Seeds Vitale, Arturo Alberto Acher, Andrés Pomilio, Alicia Beatriz Alkaloids of Datura ferox from Argentina
topic_facet	3-Phenylacetoxy-6β,7β-epoxytropane (3-phenylacetoxyscopine) 3α-Tigloyloxytropane (tigloyltropeine) 7β-Hydroxy-6β-isovaleroyloxy-3α-tigloyloxytropane 7β-Hydroxy-6β-propenyloxy-3α-tropoyloxytropane Aposcopolamine (apohyoscine) Datura ferox GC-MS HPLC Hygrine Scopolamine (hyoscine) Tropane alkaloids hyoscyamine nicotine plant extract scopolamine tropane alkaloid tropane derivative argentina article drug determination drug isolation drug structure drug toxicity gas chromatography high performance liquid chromatography mass spectrometry nonhuman plant seed Alkaloids Argentina Chromatography, High Pressure Liquid Humans Plant Extracts Seeds
description	Chromatographic procedures (HPLC, GC-MS) are outlined in this paper for the analysis of alkaloids in poisonous Datura ferox seeds of Argentina, from which previously only quantitative analysis for scopolamine was known. Five additional tropane alkaloids are now identified as 3α-tigloyloxytropane (tigloyltropeine), 3-phenylacetoxy-6β,7β-epoxytropane (3-phenylacetoxyscopine), aposcopolamine (apohyoscine), 7β-hydroxy-6β-propenyloxy-3α-tropoyloxytropane, traces of 7β-hydroxy-6β-isovaleroyloxy-3α-tigloyloxytropane and a pyrrolidine alkaloid, hygrine. Two new structures, 3-phenylacetoxy-6β,7β-epoxytropane (3-phenylacetoxyscopine) and 7β-hydroxy-6β-propenyloxy-3α-tropoyloxytropane, are proposed on the basis of their spectra. Hyoscyamine, nicotine and tropane N-oxides were not detected in all samples studied. © 1995.
author	Vitale, Arturo Alberto Acher, Andrés Pomilio, Alicia Beatriz
author_facet	Vitale, Arturo Alberto Acher, Andrés Pomilio, Alicia Beatriz
author_sort	Vitale, Arturo Alberto
title	Alkaloids of Datura ferox from Argentina
title_short	Alkaloids of Datura ferox from Argentina
title_full	Alkaloids of Datura ferox from Argentina
title_fullStr	Alkaloids of Datura ferox from Argentina
title_full_unstemmed	Alkaloids of Datura ferox from Argentina
title_sort	alkaloids of datura ferox from argentina
publishDate	1995
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03788741_v49_n2_p81_Vitale http://hdl.handle.net/20.500.12110/paper_03788741_v49_n2_p81_Vitale
work_keys_str_mv	AT vitalearturoalberto alkaloidsofdaturaferoxfromargentina AT acherandres alkaloidsofdaturaferoxfromargentina AT pomilioaliciabeatriz alkaloidsofdaturaferoxfromargentina
_version_	1768543137811136512

Alkaloids of Datura ferox from Argentina

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