Microstructure and transport properties of biocompatible silica hydrogels
Abstract: Silica matrices are suitable for encapsulation of biomolecules and microorganisms to build bioactive functional materials. For many applications of these host–guest systems, the performance highly depends on the tuning of transport properties. Here we analyze the microstructure of silica h...
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09280707_v77_n2_p437_Perullini http://hdl.handle.net/20.500.12110/paper_09280707_v77_n2_p437_Perullini |
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paper:paper_09280707_v77_n2_p437_Perullini2025-07-30T18:28:21Z Microstructure and transport properties of biocompatible silica hydrogels Perullini, Ana Mercedes SAXS microstructure characterization Silica hydrogels TEOS alcohol-free route Transport properties Biocompatibility Crystal microstructure Dyes Electron transport properties Functional materials Hydrogels Microstructure Sols Surface diffusion Synthesis (chemical) Transport properties X ray scattering Apparent diffusion coefficient Biotechnological applications Macroscopic properties Micro-structure parameters Microscopic parameter Microstructure characterization Silica concentrations TEOS alcohol-free route Silica Abstract: Silica matrices are suitable for encapsulation of biomolecules and microorganisms to build bioactive functional materials. For many applications of these host–guest systems, the performance highly depends on the tuning of transport properties. Here we analyze the microstructure of silica hydrogels from small-angle X-ray scattering (SAXS) experiments and its correlation with their transport properties evaluated from the fitting of diffusional profiles of the cationic dye crystal violet (CV). We found a clear correlation between the microstructure parameters and the transport of CV over a wide range of synthesis conditions (SiO 2 total content from 3.6 to 9.0 % and pH of silica condensation from 4.5 to 7.5). At pH ~ 6, non-monotonic changes in transport properties can be attributed to the discontinuity observed in microscopic parameters, revealing the inherent complexity of the sol–gel transition. However, regardless of the pH of synthesis and for each set of samples with a fixed silica concentration, CV apparent diffusion coefficient (D app ) is inversely proportional to the parameter S (related to the silica/aqueous-solution interfacial area) derived from SAXS. These results indicate that macroscopic properties cannot be easily predicted from the pH of synthesis, in particular around neutral pH that is relevant for biotechnological applications. Nonetheless, the close correlation between D app and the microstructure parameters of the studied systems allows proposing a predictive value of any of these approaches toward the other. Graphical Abstract: [Figure not available: see fulltext.] © 2015, Springer Science+Business Media New York. Fil:Perullini, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09280707_v77_n2_p437_Perullini http://hdl.handle.net/20.500.12110/paper_09280707_v77_n2_p437_Perullini |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
SAXS microstructure characterization Silica hydrogels TEOS alcohol-free route Transport properties Biocompatibility Crystal microstructure Dyes Electron transport properties Functional materials Hydrogels Microstructure Sols Surface diffusion Synthesis (chemical) Transport properties X ray scattering Apparent diffusion coefficient Biotechnological applications Macroscopic properties Micro-structure parameters Microscopic parameter Microstructure characterization Silica concentrations TEOS alcohol-free route Silica |
| spellingShingle |
SAXS microstructure characterization Silica hydrogels TEOS alcohol-free route Transport properties Biocompatibility Crystal microstructure Dyes Electron transport properties Functional materials Hydrogels Microstructure Sols Surface diffusion Synthesis (chemical) Transport properties X ray scattering Apparent diffusion coefficient Biotechnological applications Macroscopic properties Micro-structure parameters Microscopic parameter Microstructure characterization Silica concentrations TEOS alcohol-free route Silica Perullini, Ana Mercedes Microstructure and transport properties of biocompatible silica hydrogels |
| topic_facet |
SAXS microstructure characterization Silica hydrogels TEOS alcohol-free route Transport properties Biocompatibility Crystal microstructure Dyes Electron transport properties Functional materials Hydrogels Microstructure Sols Surface diffusion Synthesis (chemical) Transport properties X ray scattering Apparent diffusion coefficient Biotechnological applications Macroscopic properties Micro-structure parameters Microscopic parameter Microstructure characterization Silica concentrations TEOS alcohol-free route Silica |
| description |
Abstract: Silica matrices are suitable for encapsulation of biomolecules and microorganisms to build bioactive functional materials. For many applications of these host–guest systems, the performance highly depends on the tuning of transport properties. Here we analyze the microstructure of silica hydrogels from small-angle X-ray scattering (SAXS) experiments and its correlation with their transport properties evaluated from the fitting of diffusional profiles of the cationic dye crystal violet (CV). We found a clear correlation between the microstructure parameters and the transport of CV over a wide range of synthesis conditions (SiO 2 total content from 3.6 to 9.0 % and pH of silica condensation from 4.5 to 7.5). At pH ~ 6, non-monotonic changes in transport properties can be attributed to the discontinuity observed in microscopic parameters, revealing the inherent complexity of the sol–gel transition. However, regardless of the pH of synthesis and for each set of samples with a fixed silica concentration, CV apparent diffusion coefficient (D app ) is inversely proportional to the parameter S (related to the silica/aqueous-solution interfacial area) derived from SAXS. These results indicate that macroscopic properties cannot be easily predicted from the pH of synthesis, in particular around neutral pH that is relevant for biotechnological applications. Nonetheless, the close correlation between D app and the microstructure parameters of the studied systems allows proposing a predictive value of any of these approaches toward the other. Graphical Abstract: [Figure not available: see fulltext.] © 2015, Springer Science+Business Media New York. |
| author |
Perullini, Ana Mercedes |
| author_facet |
Perullini, Ana Mercedes |
| author_sort |
Perullini, Ana Mercedes |
| title |
Microstructure and transport properties of biocompatible silica hydrogels |
| title_short |
Microstructure and transport properties of biocompatible silica hydrogels |
| title_full |
Microstructure and transport properties of biocompatible silica hydrogels |
| title_fullStr |
Microstructure and transport properties of biocompatible silica hydrogels |
| title_full_unstemmed |
Microstructure and transport properties of biocompatible silica hydrogels |
| title_sort |
microstructure and transport properties of biocompatible silica hydrogels |
| publishDate |
2016 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09280707_v77_n2_p437_Perullini http://hdl.handle.net/20.500.12110/paper_09280707_v77_n2_p437_Perullini |
| work_keys_str_mv |
AT perullinianamercedes microstructureandtransportpropertiesofbiocompatiblesilicahydrogels |
| _version_ |
1840326752049561600 |