Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings

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The aim of this study was to investigate the drug-loading effects on release and mechanical properties of a scleroglucan gel, with the intention of considering them in delivery systems formulations. The rheological and kinetic properties of a 2% w/w scleroglucan gel matrix loaded and 0, 0.02, 0.04,...

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Autores principales:	Rojas, Ana María Luisa, Daraio, Marta Edit
Publicado:	2005
Materias:	Biopolymer Drug loading Drug release Dynamic rheology Scleroglucan Theophylline Biopolymers Controlled drug delivery Materials testing Molecular structure Molecular weight Pharmacokinetics Rheology Drug loadings Drug-release behaviour Gel structural properties Scleroglucan gel matrix Gels drug delivery
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09598103_v54_n12_p1613_Francois http://hdl.handle.net/20.500.12110/paper_09598103_v54_n12_p1613_Francois
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_09598103_v54_n12_p1613_Francois
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spelling	paper:paper_09598103_v54_n12_p1613_Francois2025-07-30T18:33:19Z Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings Rojas, Ana María Luisa Daraio, Marta Edit Biopolymer Drug loading Drug release Dynamic rheology Scleroglucan Theophylline Biopolymers Controlled drug delivery Materials testing Molecular structure Molecular weight Pharmacokinetics Rheology Drug loadings Drug-release behaviour Dynamic rheology Gel structural properties Scleroglucan gel matrix Theophylline Gels drug delivery The aim of this study was to investigate the drug-loading effects on release and mechanical properties of a scleroglucan gel, with the intention of considering them in delivery systems formulations. The rheological and kinetic properties of a 2% w/w scleroglucan gel matrix loaded and 0, 0.02, 0.04, 0.06, 0.2 0.4% w/w of theophylline (Th, used as a model drug) were investigated. Rheological measurements were performed in a controlled-stress rotational-shear rheometer under isothermal conditions. For theophylline release from the gel a flat Franz cell was used and the kinetic parameters were derived applying a semi-empirical power law. The influence of scleroglucan molar weight on kinetic and rheological behaviour was also studied. Results suggest two possible effects of drug loading on the gel network: in the 0.04-0.06% w/ w Th range a plasticizing effect and in the 0.2-0.4% w/w Th range a rigidization effect. In the first range mentioned, the changes in the gel structural properties tested by means of rheological measurements are coincident with changes in drug-release kinetics. © 2005 Society of Chemical Industry. Fil:Rojas, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Daraio, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2005 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09598103_v54_n12_p1613_Francois http://hdl.handle.net/20.500.12110/paper_09598103_v54_n12_p1613_Francois
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Biopolymer Drug loading Drug release Dynamic rheology Scleroglucan Theophylline Biopolymers Controlled drug delivery Materials testing Molecular structure Molecular weight Pharmacokinetics Rheology Drug loadings Drug-release behaviour Dynamic rheology Gel structural properties Scleroglucan gel matrix Theophylline Gels drug delivery
spellingShingle	Biopolymer Drug loading Drug release Dynamic rheology Scleroglucan Theophylline Biopolymers Controlled drug delivery Materials testing Molecular structure Molecular weight Pharmacokinetics Rheology Drug loadings Drug-release behaviour Dynamic rheology Gel structural properties Scleroglucan gel matrix Theophylline Gels drug delivery Rojas, Ana María Luisa Daraio, Marta Edit Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings
topic_facet	Biopolymer Drug loading Drug release Dynamic rheology Scleroglucan Theophylline Biopolymers Controlled drug delivery Materials testing Molecular structure Molecular weight Pharmacokinetics Rheology Drug loadings Drug-release behaviour Dynamic rheology Gel structural properties Scleroglucan gel matrix Theophylline Gels drug delivery
description	The aim of this study was to investigate the drug-loading effects on release and mechanical properties of a scleroglucan gel, with the intention of considering them in delivery systems formulations. The rheological and kinetic properties of a 2% w/w scleroglucan gel matrix loaded and 0, 0.02, 0.04, 0.06, 0.2 0.4% w/w of theophylline (Th, used as a model drug) were investigated. Rheological measurements were performed in a controlled-stress rotational-shear rheometer under isothermal conditions. For theophylline release from the gel a flat Franz cell was used and the kinetic parameters were derived applying a semi-empirical power law. The influence of scleroglucan molar weight on kinetic and rheological behaviour was also studied. Results suggest two possible effects of drug loading on the gel network: in the 0.04-0.06% w/ w Th range a plasticizing effect and in the 0.2-0.4% w/w Th range a rigidization effect. In the first range mentioned, the changes in the gel structural properties tested by means of rheological measurements are coincident with changes in drug-release kinetics. © 2005 Society of Chemical Industry.
author	Rojas, Ana María Luisa Daraio, Marta Edit
author_facet	Rojas, Ana María Luisa Daraio, Marta Edit
author_sort	Rojas, Ana María Luisa
title	Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings
title_short	Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings
title_full	Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings
title_fullStr	Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings
title_full_unstemmed	Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings
title_sort	rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings
publishDate	2005
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09598103_v54_n12_p1613_Francois http://hdl.handle.net/20.500.12110/paper_09598103_v54_n12_p1613_Francois
work_keys_str_mv	AT rojasanamarialuisa rheologicalanddrugreleasebehaviourofascleroglucangelmatrixatdifferentdrugloadings AT daraiomartaedit rheologicalanddrugreleasebehaviourofascleroglucangelmatrixatdifferentdrugloadings
_version_	1840323036971008000

Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings

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