Solubility and Stability of β-Cyclodextrin-Terpineol Inclusion Complex as Affected by Water

In the present work, inclusion complexes of α-terpineol (Terp) and β-cyclodextrin (BCD) were prepared by the coprecipitation method. Phase solubility studies were performed and thermodynamic parameters involved in the complex formation were calculated. The solubility of Terp increased linearly as th...

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Autores principales: Mazzobre, María Florencia, Buera, María del Pilar
Publicado: 2011
Materias:
Beta-cyclodextrin
Freeze-dried complexes
Phase solubility studies
Stability constant
Terpineol
Atmospheric humidity
Cyclodextrins
Differential scanning calorimetry
Drug products
Silanes
Sorption
Stability
Stoichiometry
Solubility
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15571858_v6_n2_p274_Mazzobre
http://hdl.handle.net/20.500.12110/paper_15571858_v6_n2_p274_Mazzobre
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
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spelling paper:paper_15571858_v6_n2_p274_Mazzobre2023-06-08T16:23:19Z Solubility and Stability of β-Cyclodextrin-Terpineol Inclusion Complex as Affected by Water Mazzobre, María Florencia Buera, María del Pilar Beta-cyclodextrin Freeze-dried complexes Phase solubility studies Stability constant Terpineol Beta-cyclodextrin Freeze-dried complexes Phase solubility studies Stability constant Terpineol Atmospheric humidity Cyclodextrins Differential scanning calorimetry Drug products Silanes Sorption Stability Stoichiometry Solubility In the present work, inclusion complexes of α-terpineol (Terp) and β-cyclodextrin (BCD) were prepared by the coprecipitation method. Phase solubility studies were performed and thermodynamic parameters involved in the complex formation were calculated. The solubility of Terp increased linearly as the concentration of BCD was increased, confirming the 1:1 stoichiometry of the complex. The stability constants decreased along with increasing temperature. The negative value of the enthalpy and of the Gibbs free energy demonstrated that the process is exothermic and spontaneous. Since complexation gives more ordered systems, the negative value obtained for the entropy change evidenced the encapsulation of Terp. Terp was completely encapsulated in BCD at the preparation conditions and studied molar ratios, as confirmed in the freeze-dried samples by differential scanning calorimeter. The presence of Terp greatly modified the BCD water sorption curves, and the amount of adsorbed water was lower for the complexes. The limited water solubility of Terp could be overcome by the formation of BCD inclusion complexes, and the complexes were stable at different storage conditions (relative humidities 11-97% and 25 °C). The obtained phase solubility data are useful for food or pharmaceutical products formulation involving cyclodextrins and stability predictions. © 2011 Springer Science+Business Media, LLC. Fil:Mazzobre, M.F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Buera, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15571858_v6_n2_p274_Mazzobre http://hdl.handle.net/20.500.12110/paper_15571858_v6_n2_p274_Mazzobre
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Beta-cyclodextrin
Freeze-dried complexes
Phase solubility studies
Stability constant
Terpineol
Beta-cyclodextrin
Freeze-dried complexes
Phase solubility studies
Stability constant
Terpineol
Atmospheric humidity
Cyclodextrins
Differential scanning calorimetry
Drug products
Silanes
Sorption
Stability
Stoichiometry
Solubility
spellingShingle Beta-cyclodextrin
Freeze-dried complexes
Phase solubility studies
Stability constant
Terpineol
Beta-cyclodextrin
Freeze-dried complexes
Phase solubility studies
Stability constant
Terpineol
Atmospheric humidity
Cyclodextrins
Differential scanning calorimetry
Drug products
Silanes
Sorption
Stability
Stoichiometry
Solubility
Mazzobre, María Florencia
Buera, María del Pilar
Solubility and Stability of β-Cyclodextrin-Terpineol Inclusion Complex as Affected by Water
topic_facet Beta-cyclodextrin
Freeze-dried complexes
Phase solubility studies
Stability constant
Terpineol
Beta-cyclodextrin
Freeze-dried complexes
Phase solubility studies
Stability constant
Terpineol
Atmospheric humidity
Cyclodextrins
Differential scanning calorimetry
Drug products
Silanes
Sorption
Stability
Stoichiometry
Solubility
description In the present work, inclusion complexes of α-terpineol (Terp) and β-cyclodextrin (BCD) were prepared by the coprecipitation method. Phase solubility studies were performed and thermodynamic parameters involved in the complex formation were calculated. The solubility of Terp increased linearly as the concentration of BCD was increased, confirming the 1:1 stoichiometry of the complex. The stability constants decreased along with increasing temperature. The negative value of the enthalpy and of the Gibbs free energy demonstrated that the process is exothermic and spontaneous. Since complexation gives more ordered systems, the negative value obtained for the entropy change evidenced the encapsulation of Terp. Terp was completely encapsulated in BCD at the preparation conditions and studied molar ratios, as confirmed in the freeze-dried samples by differential scanning calorimeter. The presence of Terp greatly modified the BCD water sorption curves, and the amount of adsorbed water was lower for the complexes. The limited water solubility of Terp could be overcome by the formation of BCD inclusion complexes, and the complexes were stable at different storage conditions (relative humidities 11-97% and 25 °C). The obtained phase solubility data are useful for food or pharmaceutical products formulation involving cyclodextrins and stability predictions. © 2011 Springer Science+Business Media, LLC.
author Mazzobre, María Florencia
Buera, María del Pilar
author_facet Mazzobre, María Florencia
Buera, María del Pilar
author_sort Mazzobre, María Florencia
title Solubility and Stability of β-Cyclodextrin-Terpineol Inclusion Complex as Affected by Water
title_short Solubility and Stability of β-Cyclodextrin-Terpineol Inclusion Complex as Affected by Water
title_full Solubility and Stability of β-Cyclodextrin-Terpineol Inclusion Complex as Affected by Water
title_fullStr Solubility and Stability of β-Cyclodextrin-Terpineol Inclusion Complex as Affected by Water
title_full_unstemmed Solubility and Stability of β-Cyclodextrin-Terpineol Inclusion Complex as Affected by Water
title_sort solubility and stability of β-cyclodextrin-terpineol inclusion complex as affected by water
publishDate 2011
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15571858_v6_n2_p274_Mazzobre
http://hdl.handle.net/20.500.12110/paper_15571858_v6_n2_p274_Mazzobre
work_keys_str_mv AT mazzobremariaflorencia solubilityandstabilityofbcyclodextrinterpineolinclusioncomplexasaffectedbywater
AT bueramariadelpilar solubilityandstabilityofbcyclodextrinterpineolinclusioncomplexasaffectedbywater
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